[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-435494-105":59,"doc-detail-435494-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","williamscampbell-syndrome-a-rare-case-of-congenital-bronchiectasis-a-case-report","Williams–Campbell syndrome: a rare case of congenital bronchiectasis - a case report","","Williams–Campbell syndrome (WCS) is a rare congenital condition involving deficiency of cartilage in subsegmental bronchi, leading to bronchiectasis and airway collapse that may present unilaterally or bilaterally. A 31-year-old man had an incidental discovery of bilateral cystic lung lesions with only mild inspiratory wheeze and no infectious or respiratory history. Diagnosis required exclusion of common causes of bronchiectasis, supported by imaging findings including dynamic CT. Chest physiotherapy and antibiotics were used as primary treatment. The report highlights diagnostic challenges in adults and the need for timely recognition.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/williamscampbell-syndrome-a-rare-case-of-congenital-bronchiectasis-a-case-report/435494/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/williamscampbell-syndrome-a-rare-case-of-congenital-bronchiectasis-a-case-report/435494.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-29",true,{"@type":101,"interactionType":102,"userInteractionCount":4},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is Williams–Campbell syndrome and why can it cause bronchiectasis?","Question",{"text":111,"@type":112},"Williams–Campbell syndrome is a rare congenital syndrome caused by deficiency of cartilage in subsegmental bronchi. This leads to bronchiectasis and airway collapse, which can be unilateral or bilateral.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How was bronchiectasis diagnosed in this case?",{"text":116,"@type":112},"The case used chest imaging (chest radiograph and high-resolution computed tomography), along with blood investigations and sputum-related evaluation. WCS diagnosis was made after excluding common causes of cystic bronchiectasis, with dynamic CT confirming the diagnosis.",{"name":118,"@type":109,"acceptedAnswer":119},"What treatments were chosen for the patient and what was the rationale?",{"text":120,"@type":112},"Chest physiotherapy and antibiotic therapy were used as primary treatments. The report emphasizes ruling out other causes while treating bronchiectasis with physiotherapy and antibiotics as the treatment of choice.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},435494,1790673857,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":128,"read_time":142},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Case Report  \nWilliams–Campbell syndrome: a rare case of congenital bronchiectasis: a case report  \nAbhyuday Kumar Yadav, MBBSa ,*, Nirish Vaidya, MDa , Sneha Shrestha, MBBSa , Bikram Yadav, MBBSb , Sampada Bhandari, MBBSa , Richa Aryal, MBBSa  \nIntroduction and importance: Williams–Campbell syndrome (WCS) is a rare congenital syndrome that can lead to bronchiectasis. Although commonly found in pediatric age groups, it can also be seen in adults due to delayed diagnosis with respiratory symptoms of cough, sputum, and wheezing.  \nPresentation of case: A 31-year-old male presented with an incidental finding of bilateral cystic lesions in the lung field for which high-resolution computed tomography of the chest was done, which showed bilateral multiple cystic lesions without any clinical findings except mild inspiratory wheeze.  \nClinical discussion  \nDiagnosis: Any suspected case of bronchiectasis must undergo imaging: chest radiograph or computed tomography scan, along with blood investigations, sputum tests, and, if needed, a biopsy to help establish a diagnosis. Diagnosis of WCS is made after exclusion of common causes, which can be cystic fibrosis, foreign body aspiration, tuberculosis, COPD, and congenital causes like bronchomalacia, Mounier–Kuhn syndrome, tracheoesophageal fistula, etc.  \nTherapeutic intervention: Chest physiotherapy, antibiotic therapy, vaccination, and pulmonary rehabilitation are primary modes of treatment. En bloc lung transplantation can be done in some cases.  \nConclusion: Diagnosis is made by ruling out all other causes of bronchiectasis, but a dynamic CT scan confirms the diagnosis. Chest physiotherapy and antibiotics are the treatment of choice.  \nKeywords: bronchiectasis, case report, congenital, Williams–Campbell syndrome  \nIntroduction  \nWilliams–Campbell syndrome (WCS) is a rare congenital syndrome characterized by a deficiency of cartilage in subsegmental bronchi, typically in 4th–6th generation, leading to bronchiectasisand airway collapse, which may be unilateral or bilateral[1] . It is thought to be of autosomal recessive origin occurring due toa genetic defect affecting the development of bronchial cartilage[2] . Chest radiograph, computed tomography (CT) scan, and bronchoscopy are few diagnostic modalities for this condition. Although the syndrome has been best described in children with recurrent pneumonia and broncho-obstructive symptoms such as coughing and wheezing, there have been recent descriptions in adults as well[3] . Patients having a less severe form of cartilage deficiency may remain asymptomatic and undiagnosed for years,  \naDepartment of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal and bDhulikhel Hospital, Dhulikhel, Nepal Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.  \n*Corresponding author. Address: Kathmandu University School ofMedical Sciences, Dhulikhel 45210, [Nepal. E-mail: abhyudayjnk1999@gmail.com](Nepal. E-mail: abhyudayjnk1999@gmail.com) (A.K. Yadav). Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nAnnals of Medicine & Surgery (2026) 88:919–923  \nReceived 29 July 2025; Accepted 27 November 2025  \nPublished online 18 December 2025  \n[http://dx.doi.org/10.1097/MS9.0000000000004550](http://dx.doi.org/10.1097/MS9.0000000000004550)  \nwhich may be the reason for the presence ofWCS of adult type[4] . This is a rare anomaly, and adequate research has not been done regarding this syndrome and its interventions, showing a gap in literature, which increases the significance of reporting such cases. Despite the syndrom","cbCaiuLEXXSdnQeC","https://ap.wps.com/l/cbCaiuLEXXSdnQeC","pdf",1198739,"English","# Introduction\n# Presentation of case\n# Clinical discussion\n## Diagnosis\n## Therapeutic intervention\n# Conclusion\n# Case presentation","[{\"question\":\"What is Williams–Campbell syndrome and why can it cause bronchiectasis?\",\"answer\":\"Williams–Campbell syndrome is a rare congenital syndrome caused by deficiency of cartilage in subsegmental bronchi. This leads to bronchiectasis and airway collapse, which can be unilateral or bilateral.\"},{\"question\":\"How was bronchiectasis diagnosed in this case?\",\"answer\":\"The case used chest imaging (chest radiograph and high-resolution computed tomography), along with blood investigations and sputum-related evaluation. WCS diagnosis was made after excluding common causes of cystic bronchiectasis, with dynamic CT confirming the diagnosis.\"},{\"question\":\"What treatments were chosen for the patient and what was the rationale?\",\"answer\":\"Chest physiotherapy and antibiotic therapy were used as primary treatments. The report emphasizes ruling out other causes while treating bronchiectasis with physiotherapy and antibiotics as the treatment of choice.\"}]","Williams–Campbell syndrome: a rare case of congenital bronchiectasis - a case report | PDF",13]