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It outlines a One Health approach and calls for improved awareness, surveillance, antimicrobial stewardship, infection prevention, funding for new treatments, and supportive governance to strengthen drug development.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/why-solutions-to-antimicrobial-resistance-are-urgently-needed/408072/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/why-solutions-to-antimicrobial-resistance-are-urgently-needed/408072.png","ImageObject",300,407,{"name":42,"@type":43},"Fans","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are solutions to antimicrobial resistance urgently needed?","Question",{"text":63,"@type":64},"AMR reduces the effectiveness of modern medicines as microbes evolve resistance, making infections increasingly difficult to treat and threatening public health outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is the One Health approach mentioned for addressing AMR?",{"text":68,"@type":64},"It emphasizes integrating human and animal health with agriculture and the environment, alongside actions like awareness, surveillance, stewardship, and prevention of transmission.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the document connect drug discovery to combating AMR?",{"text":72,"@type":64},"It argues that modern omics and data-informed biodiscovery can speed identification of promising natural products and support linking genes, molecules, and mechanisms relevant to new treatments.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},408072,1790926965,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":55,"preview_page_count":4},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","© 2025 . Published by The Company of Biologists | Disease Models & Mechanisms (2025) 18, dmm052789 . doi:10 . 1242/dmm.052789  \nEDITORIAL ANNIVERSARY ARTICLE   \nWhy solutions to antimicrobial resistance are urgently needed  \nSerge Mostowy1,* and Katherine R. Duncan2,*  \nAntimicrobial resistance (AMR) is a major global threat that concerns both emerging and existing infections. AMR occurs when microorganisms, like bacteria, viruses, fungi and parasites, evolve to resist the medicines designed to kill them, such as antibacterials, antivirals and antifungals (see also Sanyal, 2023). When the resulting‘superbugs’ cause common infections, they become difficult or impossible to treat, threatening the effectiveness of modern medicine. What is particularly concerning is the increasing frequency of multidrug-resistant (MDR) strains and extensively drug-resistant (XDR) strains, as even last-line antibiotics are being rendered ineffective. AMR is associated with significant morbidity and mortality – deaths linked to antibiotic-resistant superbugs increased by 17% in England in 2024 (data from the UK Health Security Agency, November 2025) . The Global Research on Antimicrobial Resistance (GRAM) project suggests that, if no steps are taken, 39 million deaths will be directly attributable to bacterial AMR between 2025 and 2050, which equates to approximately three deaths every minute. Treating AMR infections is a significant economic burden, costing the National Health Service in England about £180 million a year. Alarmingly, the World Bank’s modelling data suggest that, by 2030, AMR could lead to GDP losses of US$ 1.0 to 3.4 trillion per year.  \nTo mitigate this threat, a global ‘One Health ’ approach is crucial: integrating human and animal health, agriculture and the environment. It is also vital to improve public awareness and knowledge, strengthen surveillance, optimise antimicrobial stewardship, prevent infections and transmission of resistant organisms, fund research into new treatments, and improve the governance of and policies supporting drug development. To showcase these issues, Disease Models & Mechanisms (DMM) hosted a one-day symposium as part of the 100-year anniversary conference, organized by the publisher of DMM – The Company of Biologists (see Fig. 1) . Entitled ‘Interdisciplinary approaches to combatting antimicrobial resistance ’, the event was organised by Katherine Duncan (Newcastle University, UK) and DMM Editorial Advisory Board member Serge Mostowy (London School of Hygiene & Tropical Medicine, UK) . They invited international experts in the field, who are at different stages of their own research careers and use a breadth of approaches to combat AMR, ranging from fundamental basic science discovery to clinical research and real-world impact. With this symposium, our goal was to draw attention to exciting and emerging concepts in AMR, and to discuss real-world solutions. Finally, we hoped to introduce DMM readers  \n1Department of Infection Biology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK. 2Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.  \n*Authors for correspondence ([serge. mostowy@lshtm.ac.uk](serge. mostowy@lshtm.ac.uk); [Katherine.Duncan@newcastle.ac.uk](Katherine.Duncan@newcastle.ac.uk))  \n S. M. , 0000-0002-7286-6503; K. R. D. , 0000-0002-3670-4849  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0](https://creativecommons.org/licenses/by/4.0)), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.  \nto the multifaceted disciplines underlying AMR science and inspire ways in which their own research may one day contribute.  \nDrug discovery and ‘omics  \nNatural products (arising from living organism chemistry) have long been a source of medicine (Mostowy, 2022) . Now, with modern‘","cbCaisk7ywnBCMPy","https://ap.wps.com/l/cbCaisk7ywnBCMPy","pdf",810075,"English","# Overview of AMR urgency\n# One Health approach for mitigation\n# Drug discovery and omics","[{\"question\":\"Why are solutions to antimicrobial resistance urgently needed?\",\"answer\":\"AMR reduces the effectiveness of modern medicines as microbes evolve resistance, making infections increasingly difficult to treat and threatening public health outcomes.\"},{\"question\":\"What is the One Health approach mentioned for addressing AMR?\",\"answer\":\"It emphasizes integrating human and animal health with agriculture and the environment, alongside actions like awareness, surveillance, stewardship, and prevention of transmission.\"},{\"question\":\"How does the document connect drug discovery to combating AMR?\",\"answer\":\"It argues that modern omics and data-informed biodiscovery can speed identification of promising natural products and support linking genes, molecules, and mechanisms relevant to new treatments.\"}]","Why solutions to antimicrobial resistance are urgently needed | PDF",1790578176]