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This study examines how multiple neighborhood environment domains relate to ADRD risk in U.S. adults aged 60+ using All of Us data (N=15,683) and ADRD diagnosis from Electric Health Records. Factor analysis identified four domains, and structural equation modeling tested associations while controlling sociodemographic and behavioral factors. Greater environmental disorder and fewer accessible facilities predicted higher ADRD diagnosis risk, and perceived neighborhood safety related to lower risk.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/where-you-live-matters-neighborhood-environment-and-dementia-risks-among-us-older-adults/423727/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/where-you-live-matters-neighborhood-environment-and-dementia-risks-among-us-older-adults/423727.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main research focus of this study?","Question",{"text":113,"@type":114},"The study evaluates the association between neighborhood environment characteristics and the risk of ADRD among U.S. older adults.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which data sources and participant sample are used?",{"text":118,"@type":114},"It uses nationally representative All of Us data with 15,683 respondents aged 60+ and ADRD diagnosis from Electric Health Records.",{"name":120,"@type":111,"acceptedAnswer":121},"What neighborhood factors were identified and how did they relate to ADRD risk?",{"text":122,"@type":114},"Factor analysis identified physical environment disorders, accessibility of facilities, relationship with neighbors, and neighborhood safety. More environmental disorders and fewer accessible facilities were linked to higher ADRD diagnosis risk, while perceived neighborhood safety was linked to lower risk.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},423727,1790793806,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81,"preview_page_count":4},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","266 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.891  \nWHERE YOU LIVE MATTERS: NEIGHBORHOOD  \nENVIRONMENT AND DEMENTIA RISKS AMONG U.S.  \nOLDER ADULTS  \nHaowei Wang, Syracuse University, Syracuse, New York, United States  \nAlzheimer’s Disease and Related Dementias (ADRD) are a growing public health crisis among older adults. Emerging research suggests that neighborhood environment plays a significant role in ADRD risks. This study explores the association between various aspects of neighborhood environment and the risk of ADRD in the US older adult population. We used a large scale, nationally representative data from the All of Us research program, including N = 15,683 respondents aged 60+ .  \nRespondents provided information about their neighborhood environment and their ADRD diagnosis was accessed using Electric Health Records. Using factor analysis, we identified four aspects of neighborhood environment, including physical environment disorders, accessibility of facilities, relationship with neighbors, and neighborhood safety. We estimated structural equation models (SEM) with latent variables to analyze the relationship between ADRD risk and multiple aspects neighborhood environment, controlling for respondents’ sociodemographic and behavioral characteristics. SEM results showed that older adults had higher risks of ADRD diagnosis if there were more environmental disorders and fewer accessible facilities in the neighborhood. Perceived neighborhood safety was also associated with a lower risk of ADRD diagnosis among older adults. Understanding how neighborhood environments contribute to ADRD risk is crucial for developing targeted public health interventions and promoting healthy cognitive aging for older adults in the US.","cbCaissZA7jx2inF","https://ap.wps.com/l/cbCaissZA7jx2inF","pdf",286281,"English","# Abstract\n## Study design and data sources\n## Neighborhood environment domains\n## Statistical analysis and main findings\n## Implications for public health interventions","[{\"question\":\"What is the main research focus of this study?\",\"answer\":\"The study evaluates the association between neighborhood environment characteristics and the risk of ADRD among U.S. older adults.\"},{\"question\":\"Which data sources and participant sample are used?\",\"answer\":\"It uses nationally representative All of Us data with 15,683 respondents aged 60+ and ADRD diagnosis from Electric Health Records.\"},{\"question\":\"What neighborhood factors were identified and how did they relate to ADRD risk?\",\"answer\":\"Factor analysis identified physical environment disorders, accessibility of facilities, relationship with neighbors, and neighborhood safety. More environmental disorders and fewer accessible facilities were linked to higher ADRD diagnosis risk, while perceived neighborhood safety was linked to lower risk.\"}]","WHERE YOU LIVE MATTERS - Neighborhood Environment and Dementia Risks Among U.S. Older Adults | PDF",1790631784]