[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-405735-105":59,"doc-detail-405735-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","welders-anthrax-treated-with-obiltoxaximablouisiana-2024","Welder’s Anthrax Treated with Obiltoxaximab—Louisiana, 2024","","In September 2024, the ninth documented case of welder’s anthrax was identified in a previously healthy 18-year-old male welder from Louisiana, hospitalized with pneumonia and respiratory failure requiring intubation and mechanical ventilation. Welder’s anthrax is a recently described life-threatening pneumonia caused by anthrax toxin–producing Bacillus cereus group bacteria. A coordinated state and federal response enabled obiltoxaximab (Anthim) plus recommended multidrug inhalation anthrax antimicrobials. The patient improved rapidly, underwent pleural effusion drainage, and was discharged after 26 days, with full resolution by 3-month follow-up. Environmental testing detected anthrax toxin genes in 11.4% of soil and surface samples, yet no clear host or occupational factor was identified. Enhanced workplace safety could reduce exposure to infectious agents among metalworkers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/welders-anthrax-treated-with-obiltoxaximablouisiana-2024/405735/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/welders-anthrax-treated-with-obiltoxaximablouisiana-2024/405735.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is welder’s anthrax and what causes it?","Question",{"text":112,"@type":113},"Welder’s anthrax is a life-threatening pneumonia caused by anthrax toxin–producing Bacillus cereus group bacteria.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the Louisiana 2024 case treated and what was the outcome?",{"text":117,"@type":113},"The patient received obiltoxaximab (Anthim) alongside recommended multidrug antimicrobial therapy for inhalation anthrax and had drainage of a pleural effusion. 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Thompson, DVM, PhD*,1,2; Eric W. Lundstrom, PhD*,2,3; Lindsay D. Hein, PhD1,4; Cari A. Beesley, MS 1; Chung K. Marston 1; Rebecca Zaayenga 1; Christopher A. Gulvik, PhD 1; Taylor K. Paisie, MS 1; Julie Hand, MSPH5; Chad H. Dowell, MS6; Karl Feldmann, MS3; Dawn Blackburn, BVMS 1; Caroline A. Schrodt, MD 1; William A. Bower, MD 1; Katherine M. DeBord, MPH 1; Brian T. Richardson, Jr., MPH 1; Danielle Haydel7; Latira Haynes, MBA, MHA, MLS7; Patricia A. Yu, MPH8; Yon Yu, PharmD8; Abigail Cocco, DO9; Maren Bell-Do, MD9; Michael Bacon, MD9; James Antonini, PhD 10; Nancy Burton, PhD3; Zachary P. Weiner, PhD 1; Alex R. Hoffmaster, PhD 1; Marie A. de Perio, MD6;  \nCaitlin M. Cossaboom, DVM, PhD 1; Theresa Sokol, MPH5  \nAbstract  \nIn September 2024, the ninth documented case ofwelder’s anthrax was identified in a previously healthy male welder, aged 18 years, from Louisiana, who was hospitalized with pneumonia and respiratory failure requiring intubation and mechanical ventilation. Welder’s anthrax is a recently described life-threatening pneumonia caused by infection with anthrax toxin–producing Bacillus cereus group bacteria; risk factors for infection are not well-understood. Eight previous cases (six fatal) were reported among welders or metalworkers from Louisiana and Texas. A coordinated state and federal response facilitated use of the anthrax antitoxin obiltoxaximab (Anthim), which was administered in combination with recommended multidrug antimicrobial therapy for inhalation anthrax, including bactericidal agents and protein synthesis inhibitors. The patient’s clinical condition improved rapidly after administration of obiltoxaximab and antimicrobials and drainage of a pleural effusion. He was discharged with a tailored antibiotic regimen after a 26-day hospitalization; all of his pulmonary symptoms had resolved by his 3-month follow-up visit. An environmental investigation identified anthrax toxin genes in 28 (11.4%) of 245 soil and nonporous surface samples collected from the patient’s worksite; however, this investigation did not clearly identify host or occupational factors that contributed to his illness. Enhanced workplace safety protocolsand improved engineering and administrative controls could minimize exposure to dust and welding fumes and potentially decrease environmental exposure to infectious disease agents among metalworkers. Welder’s anthrax should be considered in the differential diagnosis of pneumonia among welders and  \n* These authors contributed equally to this report.  \nmetalworkers, particularly those who live in or have worked in the southern United States. Health care providers should consult with CDC as soon as welder’s anthrax is suspected to facilitate release of anthrax countermeasures, including antitoxins such as obiltoxaximab, as adjunctive therapy.  \nIntroduction  \nAnthrax is a serious illness caused by infection with Bacillus anthracis, a member of the Bacillus cereus group. The B. cereus group comprises closely related, gram-positive, nonmotile, spore-forming bacteria, including, in addition to B. anthracis, B. cereus species and other newly recognized species such as B. tropicus.† Virulence factors of B. anthracis include anthrax toxin and a protective capsule, encoded on plasmids pXO1 and pXO2, respectively ( 1) . Persons who have contact with infected animals or animal products can become infected with B. anthracis (2) . Infection with B. anthracis can manifest as cutaneous, gastrointestinal, or inhalation anthrax depending on how the spores enter the body (e.g., direct inoculation through skin, consumption of infected meat, or inhalation of  \n† Bacillus tropicus (formerly B. cereus) is a newly recognized Bacillus cereus group species.  \nProposal of nine novel species of the Bacillus cereu","cbCaic8gpdGghMKm","https://ap.wps.com/l/cbCaic8gpdGghMKm","pdf",376757,"English","# Abstract\n# Introduction\n## Anthrax and inhalation disease overview\n## Bacillus cereus group, toxin genes, and welder’s anthrax background\n## Focus of the investigation","[{\"question\":\"What is welder’s anthrax and what causes it?\",\"answer\":\"Welder’s anthrax is a life-threatening pneumonia caused by anthrax toxin–producing Bacillus cereus group bacteria.\"},{\"question\":\"How was the Louisiana 2024 case treated and what was the outcome?\",\"answer\":\"The patient received obiltoxaximab (Anthim) alongside recommended multidrug antimicrobial therapy for inhalation anthrax and had drainage of a pleural effusion. Rapid clinical improvement occurred, followed by discharge after 26 days and resolution of pulmonary symptoms by the 3-month follow-up.\"},{\"question\":\"What did the environmental investigation find at the patient’s worksite?\",\"answer\":\"Anthrax toxin genes were identified in 28 of 245 (11.4%) soil and nonporous surface samples. However, the investigation did not clearly identify host or occupational factors that contributed to illness.\"}]","Welder’s Anthrax Treated with Obiltoxaximab—Louisiana, 2024 | PDF",1790561630,18]