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In a 12-month INVEST in Bone Health Trial subset (n=21), REE was better preserved with weight-loss plus weighted vest than weight loss alone or weight loss plus resistance training.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/weighted-vests-preserve-resting-energy-expenditure-during-intentional-weight-loss-in-older-adults/426643/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/weighted-vests-preserve-resting-energy-expenditure-during-intentional-weight-loss-in-older-adults/426643.png","ImageObject",300,407,{"name":42,"@type":43},"Muffet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-16","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why might weighted vests reduce weight regain in older adults?","Question",{"text":63,"@type":64},"The gravitostat theory proposes that gravitational loading from a weighted vest can dampen the body’s perception of weight loss, mitigating signals that drive regain, including reduced resting energy expenditure (REE).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were interventions compared in the INVEST trial?",{"text":68,"@type":64},"The trial compared weight loss alone targeting 10% loss, weight loss plus weighted vest use (about 8 hours/day with weight replacement up to 10% total loss), and weight loss plus resistance training (three supervised sessions per week).",{"name":70,"@type":61,"acceptedAnswer":71},"What happened to resting energy expenditure and weight at follow-up?",{"text":72,"@type":64},"At 12 months, REE was better preserved with the weighted vest strategy than with weight loss alone or resistance training. From 12 to 24 months, the weighted vest group regained the least weight, though the between-group significance was not fully conclusive.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},426643,1790813656,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30},962090768927,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","1154 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3868  \nWEIGHTED VESTS PRESERVE RESTING ENERGY  \nEXPENDITURE DURING INTENTIONAL WEIGHT  \nLOSS IN OLDER ADULTS  \nCassidy Guida1, Lauren Chandler-Holtz2, Daniel Beavers2, Philip Kramer1, Sarah Wherry3, Barbara Nicklas4, and Kristen Beavers1, 1. Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States, 2. Wake Forest University, Winston Salem, North Carolina, United States, 3. University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 4. Wake Forest University School of Medicine, Winston Salem, North Carolina, United States  \nWeight regain following intentional weight loss in older adults is a near expected occurrence. The gravitostat theory suggests that gravitational loading – in the form of a weighted vest, for instance – might dampen the body’s perception of weight loss, thus mitigating signals driving weight regain, such as reduced resting energy expenditure (REE) . The 12-month INVEST in Bone Health Trial (NCT04076618), compared WL alone (targeting 10% WL), WL plus weighted vest use (WL+VEST; 8 hours/ day, weight replacement up to 10% total WL), or WL plus resistance training (WL+RT; 3 supervised sessions/week) on bone health in 150 older adults, is an ideal platform to examine this concept. A subset of participants (n = 21) with baseline characteristics similar to the original cohort (66.9±5.4 years; 71% women; 67% white; body mass index [BMI] 33.3±3.5 kg/m²) returned for a 24-month follow up visit (12 months post-intervention) to collect REE and body weight. At intervention end (12-months), REE was better preserved in WL+VEST [+146.9 kcal/day (95% CI: 32.4, 222.4)] compared toWL alone [-52.5 kcal/day (95% CI: -137.5, 32.5)] and WL+RT [-89.7 kcal/ day (95% CI: -160.5, -18.8)]; p = 0.02. From 12 to 24 months, WL+VEST regained the least weight [+0.74 kg (95% CI:(-3.75, 5.23)], compared to WL+RT [+4.74 kg (95% CI: 0.51, 8.96)] and WL alone [+4.40 kg (95% CI (2.03, 6.77)]; p = 0.084.  \nFindings suggest that weighted vest use may attenuate long-term weight regain in older adults by preserving REE. Future work will examine other measures of energy balance, including physical activity energy expenditure and appetite hormones.","cbCaiviPWrWaNRvz","https://ap.wps.com/l/cbCaiviPWrWaNRvz","pdf",1016691,"English","# Study context\n## Gravitostat theory and hypothesis\n# Trial design and follow-up\n## Intervention arms and participants\n# Primary findings\n## REE preservation and weight regain\n# Implications and future directions","[{\"question\":\"Why might weighted vests reduce weight regain in older adults?\",\"answer\":\"The gravitostat theory proposes that gravitational loading from a weighted vest can dampen the body’s perception of weight loss, mitigating signals that drive regain, including reduced resting energy expenditure (REE).\"},{\"question\":\"How were interventions compared in the INVEST trial?\",\"answer\":\"The trial compared weight loss alone targeting 10% loss, weight loss plus weighted vest use (about 8 hours/day with weight replacement up to 10% total loss), and weight loss plus resistance training (three supervised sessions per week).\"},{\"question\":\"What happened to resting energy expenditure and weight at follow-up?\",\"answer\":\"At 12 months, REE was better preserved with the weighted vest strategy than with weight loss alone or resistance training. From 12 to 24 months, the weighted vest group regained the least weight, though the between-group significance was not fully conclusive.\"}]","WEIGHTED VESTS PRESERVE RESTING ENERGY EXPENDITURE DURING INTENTIONAL WEIGHT LOSS IN OLDER ADULTS | PDF",1790641264]