[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-442761-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-442761-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","weber-christian-disease-in-a-12-year-old-filipino-female-a-case-report","Weber-Christian Disease in a 12-year-old Filipino Female - A Case Report","","Weber-Christian Disease (WCD), a rare relapsing febrile nodular panniculitis, is usually seen in women aged 40–75 years, but occurs far less often in children. This case describes a 12-year-old Filipino girl with a 4-month history of facial nodules, thigh pains, and recurrent fever. Extensive evaluation for hypersensitivity, autoimmune, hematologic, and infectious causes was unremarkable, while biopsy confirmed WCD. Gradual improvement followed systemic therapy including steroids, hydroxychloroquine, and topical indomethacin, with no new lesions on follow-up.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/weber-christian-disease-in-a-12-year-old-filipino-female-a-case-report/442761/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/weber-christian-disease-in-a-12-year-old-filipino-female-a-case-report/442761.png","ImageObject",300,407,{"name":42,"@type":43},"PakDamar76","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What condition is described in this case report?","Question",{"text":63,"@type":64},"The report describes Weber-Christian Disease (WCD), also known as relapsing febrile nodular panniculitis, presenting with cutaneous nodules and systemic symptoms.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the diagnosis confirmed?",{"text":68,"@type":64},"An abdominal skin lesion was biopsied, and the histologic findings were consistent with WCD.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatments were used and what was the outcome?",{"text":72,"@type":64},"The patient was started on steroids, hydroxychloroquine, and topical indomethacin, with gradual improvement and progressively decreasing lesion size on follow-up without new lesions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},442761,1790793848,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","CASE REPORT  \nWeber-Christian Disease in a 12-year-old Filipino Female: A Case Report  \nMaiko P. Jao, MD and Karen Joy N. Kimseng, MD  \nChong Hua Hospital  \nABSTRACT  \nWeber-Christian Disease (WCD), or relapsing febrile nodular panniculitis is a rare form of subcutaneous fat inflammation commonly affecting women aged 40-75 years old. It is rarer in children with only 1 previously reported case in the Philippines. It presents as erythematous nodules, frequently affecting the lower extremities. There is no standard treatment, but reportedly improves with steroid therapy, cyclosporine, and immunomodulators.  \nThis is a case of a 12-year-old-female, who presented with a 4-month history of palpable facial nodules, thigh pains, and recurrent fever. Work-up for hypersensitivity reaction, autoimmune condition, hematologic problem, or infectious etiology yielded unremarkable findings, and corresponding management had no significant response. Patient developed firm lesions on the abdomen which was sent for biopsy and showed results consistent with WCD. Steroid, hydroxychloroquine, and topical indomethacin were then started and noted gradual improvement of the lesions. Patient was then discharged improved with lesions noted to progressively decrease in size and with no appearance of newer lesions upon follow-up.  \nWCD is a rare form of nodular panniculitis, more so in the younger age group. It is characterized by presence of cutaneous lesions associated with systemic symptoms. Skin biopsy is necessary to confirm its diagnosis. Visceral organ involvement and failure to respond to treatment may result to poor prognosis, and occasionally leads to death.  \nKeywords: Weber–Christian Disease, panniculitis, relapsing febrile nodular panniculitis, case report  \nINTRODUCTION  \neISSN 2094-9278 (Online) Published: November 28, 2025  \n[https://doi.org/10.47895/amp.vi0.11350](https://doi.org/10.47895/amp.vi0.11350)  \n[Copyright: The Author](Copyright: The Author)([s](s)) 2025  \nCorresponding author: Maiko P. Jao, MD Chong Hua Hospital  \nDon Mariano Cui Street, Brgy. Capitol Site, Cebu City, Philippines  \nEmail: [jaomaikop@gmail.com](jaomaikop@gmail.com)  \nWeber-Christian Disease (WCD), also known as PfeiferWeber-Christian disease or idiopathic lobular panniculitis or relapsing febrile nodular panniculitis, is a form of lobular panniculitis of unknown etiology. It was first described by Pfeifer in 1892 and was established in 1980s by Weber and Christian.1 The documented cases are rare in adults and even rarer in children. The reported cases are commonly in the fourth to seventh decade of life, 75% of which comprises women.2 In the pediatric population, a study in Brazil showed that only 6 out of 30 cases fulfilled the criteria for WCD in a 20-year review.3 Only two cases are documented in the Philippine Pediatric Registry from January 2006-January 2025.4  \nThe disease is characterized by presence of erythematous, occasionally tender subcutaneous nodules, frequently seen on the lower extremities. It is associated with systemic symptoms. The commonly reported symptoms are recurrent episodes of high fever, general malaise, arthralgia or myalgia.5-8 Organ involvement may also occur with WCD. In a study by Rotondo et al., among adult patients with WCD, liver is one of the frequent organs involved. Heart, lungs, orbits and intestines may also be affected. Inflammation in the  \nWCD in a Filipino Child  \nvisceral organs causes significant morbidity and mortality in the patient.6 A skin biopsy of the cutaneous lesion is needed to confirm its diagnosis where an infiltration of lymphocytes in the subcutaneous tissue is noted. There is currently no standard treatment for this disease. Systemic steroids have been used which showed promising result. Other treatment options include cyclosporin, mycophenolatemofetil, immunomodulators, and fibrinolytic agents.7-10  \nWe report a case of a 12-year-old female, who presents with a 4-month history of palpable facial nodule","cbCaibPlosuPYjRM","https://ap.wps.com/l/cbCaibPlosuPYjRM","pdf",1535906,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What condition is described in this case report?\",\"answer\":\"The report describes Weber-Christian Disease (WCD), also known as relapsing febrile nodular panniculitis, presenting with cutaneous nodules and systemic symptoms.\"},{\"question\":\"How was the diagnosis confirmed?\",\"answer\":\"An abdominal skin lesion was biopsied, and the histologic findings were consistent with WCD.\"},{\"question\":\"What treatments were used and what was the outcome?\",\"answer\":\"The patient was started on steroids, hydroxychloroquine, and topical indomethacin, with gradual improvement and progressively decreasing lesion size on follow-up without new lesions.\"}]","Weber-Christian Disease in a 12-year-old Filipino Female - A Case Report | PDF",1790701551,15]