[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-441524-105":59,"doc-detail-441524-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","wearable-devices-detect-physiological-changes-that-precede-and-are-associated-with-symptomatic-and-inflammatory-rheumatoid-arthritis-flares","Wearable devices detect physiological changes that precede and are associated with symptomatic and inflammatory rheumatoid arthritis flares","","Wearable devices can support continuous monitoring of rheumatoid arthritis (RA), where disease flares are unpredictable and symptoms may not align with inflammation. In a study of 53 participants, Apple Watch, Fitbit, or Oura Ring collected heart rate, resting heart rate, heart rate variability, and step data while participants completed daily symptom surveys and laboratory inflammatory assessments. Mixed-effects models linked HR, RHR, steps, and circadian HRV patterns to flare versus remission, with metric changes appearing up to 4 weeks before flare onset.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/wearable-devices-detect-physiological-changes-that-precede-and-are-associated-with-symptomatic-and-inflammatory-rheumatoid-arthritis-flares/441524/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/wearable-devices-detect-physiological-changes-that-precede-and-are-associated-with-symptomatic-and-inflammatory-rheumatoid-arthritis-flares/441524.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study investigate about rheumatoid arthritis flares?","Question",{"text":112,"@type":113},"The study evaluates whether wearable-device physiological metrics can identify and precede both symptomatic and inflammatory RA flare development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which wearable data streams were collected from participants?",{"text":117,"@type":113},"Participants wore an Apple Watch, Fitbit, or Oura Ring and provided heart rate, resting heart rate, heart rate variability, and steps data.",{"name":119,"@type":110,"acceptedAnswer":120},"How far in advance do wearable metrics change before inflammatory or symptomatic flares?",{"text":121,"@type":113},"All measured metrics were altered up to 4 weeks prior to inflammatory and symptomatic flare development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},441524,1790919924,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nWearable devices detect physiological changes that precede and are associated with symptomatic and inflammatory rheumatoid arthritis flares  \nPragya Sharma1, Matteo Danieletto1,2, Jessica K. Whang3, Kyle Landell1,2, Drew Helmus3, Bruce E. Sands3, Mayte Suarez-Farinas4, Percio S. Gulko5 & Robert P. Hirten3,6􀀍  \nPhysiological parameters are altered in rheumatoid arthritis (RA). We evaluated whether changes in physiological metrics, collected from wearable devices, identify and precede the development of both symptomatic and inflammatory RA flares. Participants with RA answered daily disease activity surveys and provided laboratory assessments of inflammatory activity. They wore an Apple Watch (n = 35), Fitbit (n = 17), or Oura Ring (n = 3) collecting heart rate (HR), resting heart rate (RHR), heart rate variability (HRV), and steps. Linear mixed effect models were used to associate HR, RHR and steps with flare and remission periods. Cosinor mixed effect models assessed circadian features of HRV. Mixed effect logistic regression models evaluated changes in physiological metrics prior to the onset  \nof flares. The study enrolled 53 participants (88.7% female) with a mean age of 51.1 (SD 15.2) years. Each contributed a mean of 105 (SD 97) days of data. Mean steps were lower, while mean nighttime HR was higher during symptomatic periods, compared to periods of symptomatic remission. Means daily HR, daytime HR, nighttime HR, and RHR were higher during periods of inflammatory flares, compared to inflammatory remission. Circadian features of HRV differentiated inflammatory and symptomatic flares from remission. All metrics were altered up to 4 weeks prior to inflammatory and symptomatic flare development. This suggests the potential use of wearable devices for disease monitoring and flare prediction.  \nKeywords Wearable device, Rheumatoid arthritis, Inflammation, Prediction  \nRheumatoid arthritis (RA) is a chronic immune mediated inflammatory disease characterized by inflammation of the joints and symptoms such as joint pain, swelling, stiffness and reduced mobility1. Its management is challenging due to the unpredictable nature of disease flares. Furthermore, there can be discordance between inflammation and symptoms, and between physician assessed and patient reported RA activity2. Monitoring modalities are currently limited to single time point infrequent clinical visits, laboratory testing and cliniciandependent or patient reported assessments3,4.  \nWearable devices are widely adopted by the general population and provide a novel means to passively and continuously assess physiological parameters outside the clinical setting. Through remote patient monitoring, these devices are increasingly utilized in the management of chronic conditions such as diabetes and heart failure, where their use has been associated with improved disease outcomes5,6. There is growing interest in the use of wearable devices to monitor inflammatory diseases7. However, in RA few studies have examined their utility for tracking disease activity, with most focusing on physical activity metrics. One study of 155 participants  \n1Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2The Hasso Plattner Institute for Digital Health at the Mount Sinai, Icahn School of Medicine at Mount Sinai, NewYork, NY, USA. 3The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4Department of Population Health Science and Policy, Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, NewYork, NY, USA. 61468 Madison Avenue, Annenberg Building RM 5-12, New York, NY 10029, USA. 􀀍 email: [robert.hirten@mountsinai.org](robert.hirten@mountsinai.org)  \n[w","cbCaiobEMAWyJPYP","https://ap.wps.com/l/cbCaiobEMAWyJPYP","pdf",2866226,11,"English","# Introduction\n# Study Methods and Data Collection\n# Statistical Modeling and Outcomes\n# Results Summary\n# Background on RA Monitoring and Autonomic Function","[{\"question\":\"What question does the study investigate about rheumatoid arthritis flares?\",\"answer\":\"The study evaluates whether wearable-device physiological metrics can identify and precede both symptomatic and inflammatory RA flare development.\"},{\"question\":\"Which wearable data streams were collected from participants?\",\"answer\":\"Participants wore an Apple Watch, Fitbit, or Oura Ring and provided heart rate, resting heart rate, heart rate variability, and steps data.\"},{\"question\":\"How far in advance do wearable metrics change before inflammatory or symptomatic flares?\",\"answer\":\"All measured metrics were altered up to 4 weeks prior to inflammatory and symptomatic flare development.\"}]","Wearable devices detect physiological changes that precede and are associated with symptomatic and inflammatory rheumatoid arthritis flares | PDF",1790696408,28]