[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-426862-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-426862-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","wearable-continuous-glucose-monitoring-and-cognitive-performance-in-older-adults-with-type-2-diabetes-abstract","WEARABLE CONTINUOUS GLUCOSE MONITORING AND COGNITIVE PERFORMANCE IN OLDER ADULTS WITH TYPE 2 DIABETES - Abstract","","Limited evidence links continuous glucose monitoring (CGM) with cognitive performance, largely studied in type 1 diabetes. This work examines associations between CGM metrics and cognition in adults over 60 with type 2 diabetes using blinded Abbott FreeStyle Libre 3 sensors for 14 days and WAIS-III Digit Span, Trails A/B, MINT, and Block Design. Interim data (n=30) show that reduced time in low glucose relates to better Block Design, while greater variability and high-glucose time show trends toward poorer language and slower executive measures. A wearable CGM protocol is feasible and yields clinically relevant predictors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address?","Question",{"text":63,"@type":64},"The study evaluates whether continuous glucose monitoring metrics are associated with cognitive performance in older adults with type 2 diabetes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were participants monitored and cognition assessed?",{"text":68,"@type":64},"Participants over 60 with self-reported type 2 diabetes wore blinded Abbott FreeStyle Libre 3 sensors for 14 days, and completed WAIS-III Digit Span, Trails A and B, MINT, and WAIS-III Block Design.",{"name":70,"@type":61,"acceptedAnswer":71},"Which CGM metrics were most predictive of cognition in the interim analysis?",{"text":72,"@type":64},"Less time in low glucose was associated with higher Block Design scores, while greater variability and more time in high glucose showed trends with worse MINT scores and slower Trails B performance.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},426862,1790774702,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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AND COGNITIVE PERFORMANCE IN OLDER ADULTS WITH TYPE 2 DIABETES  \nClaire Hoogendoorn1, Angel Garcia De La Garza2, Nelson Roque3, Cuiling Wang2, Richard Lipton2, and  \nJeffrey Gonzalez1, 1. Yeshiva University, New York, New York, United States, 2. Albert Einstein College of Medicine, Bronx, New York, United States, 3. The Pennsylvania State University, University Park, Pennsylvania, United States  \nLimited work has evaluated continuous glucose monitoring (CGM) in relation to cognitive performance, and this has been conducted largely in type 1 diabetes. We explore associations between CGM and cognition among older adults with type 2 diabetes (T2D) . Data are from community-residing adults overage 60 enrolled in the Einstein Aging Study, who self-reported T2D. Participants wore blinded Abbott FreeStyle Libre 3 sensors for 14 days and completed the WAIS III Digit Span, Trails A and B, Multilingual Naming(MINT), and WAIS III Block Design. CGM metrics include mean glucose, variability(coefficient of variation),%time in range(70-180 mg/dL),%time low(\u003C70 mg/dL),%time high(181-250 mg/dL), and %time in very high(>250 mg/ dL) glucose. Linear regression models were adjusted for age, sex, education and race/ethnicity. Interim analysis of the first 30 participants(73.9±7.4yrs, 56% female) indicate that they spent 73.8% of their time in range, 16.4% in high, 8.5% in very high, and 1.3% in low glucose. Less time in low glucose was associated with better Block Design scores(β =0.35,p=0.041). More variability showed a trend with worse MINT scores(β = 0.36,p=0.058) and more time in high showed a trend with slower Trail B performance(β = 0.37,p=0.097) . Metrics were not associated with Digit Span or Trail A. A wearable CGM protocol is feasible in older adults and identified clinically relevant metrics that were associated with cognitive performance inT2D. Time in hypo-and hyperglycemia, and variability, were most predictive, with each linked to different cognitive functions including visuospatial processing, language, and executive function. Analyses will be extended to the larger sample.","cbCaidzY81YCprAr","https://ap.wps.com/l/cbCaidzY81YCprAr","pdf",53296,"English","# Study background and aim\n## Methods and measures\n## Interim results\n## Conclusions and next steps","[{\"question\":\"What question does the study address?\",\"answer\":\"The study evaluates whether continuous glucose monitoring metrics are associated with cognitive performance in older adults with type 2 diabetes.\"},{\"question\":\"How were participants monitored and cognition assessed?\",\"answer\":\"Participants over 60 with self-reported type 2 diabetes wore blinded Abbott FreeStyle Libre 3 sensors for 14 days, and completed WAIS-III Digit Span, Trails A and B, MINT, and WAIS-III Block Design.\"},{\"question\":\"Which CGM metrics were most predictive of cognition in the interim analysis?\",\"answer\":\"Less time in low glucose was associated with higher Block Design scores, while greater variability and more time in high glucose showed trends with worse MINT scores and slower Trails B performance.\"}]","WEARABLE CONTINUOUS GLUCOSE MONITORING AND COGNITIVE PERFORMANCE IN OLDER ADULTS WITH TYPE 2 DIABETES - Abstract | PDF",1790642061]