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This study examines the association between walking speed and risk of any cancer and five common cancers, and tests whether inflammation and lipid or glucose metabolism biomarkers mediate the relationship. Analyses use UK Biobank data plus an independent Hong Kong cohort, applying Cox models and mediator models.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/walking-speed-and-risk-of-cancer-in-two-prospective-cohort-studies/376004/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/walking-speed-and-risk-of-cancer-in-two-prospective-cohort-studies/376004.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about walking speed and cancer?","Question",{"text":112,"@type":113},"It investigates whether walking speed relates to the risk of any cancer and five common cancers, and whether biomarker pathways involving inflammation, lipids, and glucose help explain the relationship.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were walking speed and cancer outcomes measured in the two cohorts?",{"text":117,"@type":113},"Walking speed was self-reported in the UK Biobank and measured with a timed 6-m walk test in the Hong Kong Osteoporosis Study. Incident cancer cases were identified using electronic health records.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings on cancer risk with faster walking speed?",{"text":121,"@type":113},"Across follow-up, faster walking speed was associated with a reduced risk of any cancer. The study also reports associations with lung cancer and prostate cancer risk patterns, depending on the cohort and cancer type.",{"name":123,"@type":110,"acceptedAnswer":124},"Did biomarkers mediate the association between walking speed and cancer?",{"text":125,"@type":113},"Yes. Mediation analyses in the UK Biobank show that inflammation and metabolic biomarkers, including CRP, WBC count, total cholesterol, LDL cholesterol, and glucose levels, partially mediated the association, with a combined mediated proportion across five mediators reported in the results.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},376004,1790813675,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","Journal of Cachexia, Sarcopenia and Muscle  \n ORIGINAL ARTICLE  OPEN ACCESS   \nWalking Speed and Risk of Cancer in Two Prospective Cohort Studies  \nJonathan K. L. Mak1,2  | Kathryn Choon Beng Tan3  | Juulia Jylhävä2,4,5  | Sara Hägg2  | Ching-Lung Cheung1,6,7   \n1Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China | 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden | 3Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China | 4Faculty of Medicine and Health Technology and Gerontology Research Center (GEREC), Tampere University, Tampere, Finland | 5Tampere Institute for Advanced Study, Tampere, Finland | 6Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA | 7Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Pak Shek Kok, Hong Kong, SAR, China  \nCorrespondence: Ching-Lung Cheung (lung1212@hku.hk)  \nReceived: 26 September 2024 | Revised: 2 January 2025 | Accepted: 10 March 2025  \nFunding: This study was supported by the Swedish Cancer Society (21 1571 Pj), the Swedish Research Council (grant no. 2018-02077, 2019-01272, 2020-06101, 2022-01608), the Research Council of Finland (grant no. 3493358), the Sigrid Jusélius Foundation, the Yrjö Jahnsson Foundation (grant no. 20217416), the Instrumentarium Science Foundation, and the Signe and Ane Gyllenberg Foundation (grant no. 6226). The funders had no role in the design, conduct, analysis, or reporting of this study.  \nKeywords: cancer | cohort study | gait speed | physical activity | sarcopenia  \nABSTRACT  \nBackground: Walking speed is a reliable marker of sarcopenia and a strong predictor of mortality, but its relationship with cancer incidence remains largely unexplored. We aimed to investigate the association between walking speed and the risk of any cancer and five common cancers, including lung, breast, colorectum, prostate, and stomach, and to explore potential mediation by biomarkers of inflammation, and lipid and glucose metabolism.  \nMethods: The primary analysis was conducted in 431 598 participants from the UK Biobank (mean age 56.3 [SD 8.1] years at baseline), and the generalizability of findings was further tested in 1311 participants from the Hong Kong Osteoporosis Study (HKOS; mean age 57.8 [SD 11.9] years). Walking speed was self-reported in the UK Biobank and measured using a timed 6-m walk test in the HKOS. Incident cancer cases were identified from electronic health records. We used Cox models, adjusted for age, sex, height, body mass index, socioeconomic, lifestyle factors, family history of cancer, and grip strength, to estimate the association between walking speed and cancer incidence. Single and multiple mediator models were performed in the UK Biobank to examine the mediating effects of C-reactive protein (CRP), white blood cell (WBC) count, total cholesterol, lowdensity lipoprotein (LDL) cholesterol, and glucose levels.  \nResults: Over a median follow-up of 10.9 and 6.9 years, 11.7% and 5.0% of the UK Biobank and HKOS participants were diagnosed with cancer, respectively. In the UK Biobank, those reported a brisk vs. slow walking pace had a 13% lower risk of any cancer (95% CI 0.84–0.90) . Similarly, HKOS participants with a faster walking speed (≥ 1.0 vs. \u003C 1.0m/s) had a 45% reduced risk of any cancer (95% CI 0.31–0.98) . In the UK Biobank, brisk walking pace was associated with a significantly decreased risk of lung cancer (hazard ratio [HR] 0.47, 95% CI 0.42–0.53) and a slightly increased risk of prostate cancer (HR 1.11, 95% CI 1.02–1.21). CRP, WBC count, total cholesterol, and LDL cholesterol significantly mediated the association between brisk walking pace and any cancer, with proportions of mediation being 6.4%(95% CI 4.4–8.7%), 11.4%(8.4–17.1%), 9.3%(7.1–12.9%), and 8.3%(6.1–11.9%), res","cbCaiqA92U1VOe00","https://ap.wps.com/l/cbCaiqA92U1VOe00","pdf",508683,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What question does the study address about walking speed and cancer?\",\"answer\":\"It investigates whether walking speed relates to the risk of any cancer and five common cancers, and whether biomarker pathways involving inflammation, lipids, and glucose help explain the relationship.\"},{\"question\":\"How were walking speed and cancer outcomes measured in the two cohorts?\",\"answer\":\"Walking speed was self-reported in the UK Biobank and measured with a timed 6-m walk test in the Hong Kong Osteoporosis Study. Incident cancer cases were identified using electronic health records.\"},{\"question\":\"What were the main findings on cancer risk with faster walking speed?\",\"answer\":\"Across follow-up, faster walking speed was associated with a reduced risk of any cancer. The study also reports associations with lung cancer and prostate cancer risk patterns, depending on the cohort and cancer type.\"},{\"question\":\"Did biomarkers mediate the association between walking speed and cancer?\",\"answer\":\"Yes. Mediation analyses in the UK Biobank show that inflammation and metabolic biomarkers, including CRP, WBC count, total cholesterol, LDL cholesterol, and glucose levels, partially mediated the association, with a combined mediated proportion across five mediators reported in the results.\"}]","Walking Speed and Risk of Cancer in Two Prospective Cohort Studies | PDF",1790216978,25]