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Although vulvar metastasis is uncommon, it may originate from nearby pelvic organs, and less frequently from breast cancer or renal cell carcinoma, with vaginal spread from clear cell renal carcinoma being especially rare. The report describes a 56-year-old patient whose right labial lesion proved metastatic from the kidney, emphasizing the need for further study.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vulvar-metastasis-in-renal-cell-carcinoma-a-case-report-highlighting-the-aggressive-nature-of-clear-cell-renal-cell-carcinoma/338671/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vulvar-metastasis-in-renal-cell-carcinoma-a-case-report-highlighting-the-aggressive-nature-of-clear-cell-renal-cell-carcinoma/338671.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What causes vulvar cancer and which patient groups are most affected?","Question",{"text":112,"@type":113},"Vulvar cancer can be linked to HPV-associated dysplasia, mainly affecting younger women, or vulvar dermatoses such as lichen sclerosus, which predominantly affects older women.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How common is metastasis to the vulva, and which primary sites are most likely to spread there?",{"text":117,"@type":113},"Metastases to the vulva are rare but can occur, especially from cancers of nearby organs such as the cervix, bladder, rectum, or anus.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the key message from the presented case report?",{"text":121,"@type":113},"A 56-year-old patient with clear cell renal carcinoma developed a right labial lesion that was identified as kidney-origin metastasis, highlighting how rare genital metastases can still reflect an aggressive disease and warrant further research.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338671,1790096249,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Case Report  \nVulvar Metastasis in Renal Cell Carcinoma: A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma  \nAndreea Boiangiu 1,2, Ana-Maria Cioca 2, Gabriel-Petre Gorecki 3,4, *, Romina-Marina Sima 1,5, Liana Ples, 1,5, Marius-Bogdan Novac 6, Ionut-Simion Coman 1,7, Valentin-Titus Grigorean 1,7, Vasile Lungu 8,  \nMihai-Teodor Georgescu 1,9 and George-Alexandru Filipescu 1,2  \nReceived: 28 November 2024  \nRevised: 22 December 2024  \nAccepted: 23 December 2024  \nPublished: 25 December 2024  \nCitation: Boiangiu, A.; Cioca, A.-M.; Gorecki, G.-P.; Sima, R.-M.; Ples,, L.; Novac, M.-B.; Coman, I.-S.; Grigorean, V.-T.; Lungu, V.; Georgescu, M.-T.; et al. Vulvar Metastasis in Renal Cell Carcinoma: A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma. Curr. Oncol. 2025, 32, 4. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/curroncol32010004](10.3390/curroncol32010004)  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; [andreea.boiangiu@umfcd.ro](andreea.boiangiu@umfcd.ro) (A.B.); romina.sima@umfcd.ro (R.-M.S.); [liana.ples@umfcd.ro](liana.ples@umfcd.ro) (L.P.); [ionut.coman@umfcd.ro](ionut.coman@umfcd.ro) (I.-S.C.); [valentin.grigorean@umfcd.ro](valentin.grigorean@umfcd.ro) (V.-T.G.); [mihai.georgescu@umfcd.ro](mihai.georgescu@umfcd.ro) (M.-T.G.); [alexandru.filipescu@umfcd.ro](alexandru.filipescu@umfcd.ro) (G.-A.F.)  \n2 Department of Obstetrics and Gynecology, Elias University Hospital, 011461 Bucharest, Romania; [anamariacioca875@gmail.com](anamariacioca875@gmail.com)  \n3 Department of Anesthesia and Intensive Care, Faculty of Medicine,“Titu Maiorescu” University,  \n031593 Bucharest, Romania  \n4 Department of Anesthesia and Intensive Care, CF2 Clinical Hospital, 011464 Bucharest, Romania  \n5 Department of Obstetrics and Gynecology, The “Bucur” Maternity,“Saint John” Hospital,  \n040294 Bucharest, Romania  \n6 Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy,  \n200349 Craiova, Romania; [marius.novac@umfcv.ro](marius.novac@umfcv.ro)  \n7 Department of Surgery, Bagdasar-Arseni Clinical Emergency Hospital, 041915 Bucharest, Romania  \n8 Department of General Surgery, CF2 Clinical Hospital, 011464 Bucharest, Romania; [vasilelungu.md@gmail.com](vasilelungu.md@gmail.com)  \n9 “Prof. Dr. Al. Trestioreanu” Oncology Discipline,“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania  \n* Correspondence: gabriel.gorecki@prof.utm.ro  \nAbstract: Vulvar cancer is one of the rarest gynecological malignancies. The development of this condition can be associated with either dysplasia linked to human papillomavirus (HPV), primarily affecting younger women, or vulvar dermatoses such as lichen sclerosus, which predominantly affect older women. Over the last decade, the incidence of vulvar cancer has risen by 0.6% annually, while the relative survival rate has declined. Although metastasis to the vulva is uncommon, it can occur, particularly from cancers in nearby organs such as the cervix, bladder, rectum, or anus. More rarely, metastases from breast cancer and renal cell carcinoma have been reported in the vulva. Vaginal metastases from clear cell renal carcinoma are especially rare. In this article, we present the case of a 56-year-old patient diagnosed with clear cell renal carcinoma, who came to our clinic with a lesion on the right labia, which was identified as a metastasis originating from the kidney. Given the rarity of genital metastases in renal cancer, such cases should be examined and discussed to encourage further research and studies.  \nKeywords","cbCaiujjkxrvzyhX","https://ap.wps.com/l/cbCaiujjkxrvzyhX","pdf",5810641,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What causes vulvar cancer and which patient groups are most affected?\",\"answer\":\"Vulvar cancer can be linked to HPV-associated dysplasia, mainly affecting younger women, or vulvar dermatoses such as lichen sclerosus, which predominantly affects older women.\"},{\"question\":\"How common is metastasis to the vulva, and which primary sites are most likely to spread there?\",\"answer\":\"Metastases to the vulva are rare but can occur, especially from cancers of nearby organs such as the cervix, bladder, rectum, or anus.\"},{\"question\":\"What is the key message from the presented case report?\",\"answer\":\"A 56-year-old patient with clear cell renal carcinoma developed a right labial lesion that was identified as kidney-origin metastasis, highlighting how rare genital metastases can still reflect an aggressive disease and warrant further research.\"}]","Vulvar Metastasis in Renal Cell Carcinoma - A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma | PDF",1790024954,18]