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Higher thiamine intake correlates with reduced HPV infection, and greater vitamin C intake links to lower cervical neoplasia risk; beta-carotene, vitamin C, and vitamin E associate with endometrial cancer risk reduction. 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\nNatalia Wierzbowska 1, *, Tomasz Olszowski 2, Dariusz Chlubek 3, *, Mateusz Kozłowski 1 and Aneta Cymbaluk-Płoska 1  \nCitation: Wierzbowska, N.;  \nOlszowski, T.; Chlubek, D.;  \nKozłowski, M.; Cymbaluk-Płoska, A. Vitamins in Gynecologic Malignancies. Nutrients 2024, 16, 1392. [https://](https://)[ ](https://)[doi.org/10.3390/nu16091392](doi.org/10.3390/nu16091392)  \nAcademic Editor: Lauri Byerley  \nReceived: 11 March 2024  \nRevised: 29 April 2024  \nAccepted: 1 May 2024  \nPublished: 5 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powsta ´nców Wielkopolskich 72, 70-111 Szczecin, Poland  \n2 Department of Hygiene and Epidemiology, Pomeranian Medical University in Szczecin, Al. Powsta ´nców Wielkopolskich 72, 70-111 Szczecin, Poland  \n3 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Al.  \nPowsta ´nców Wielkopolskich 72, 70-111 Szczecin, Poland  \n* [Correspondence: nwierzbowska0505@gmail.com](Correspondence: nwierzbowska0505@gmail.com) (N.W.); [dariusz.chlubek@pum.edu.pl](dariusz.chlubek@pum.edu.pl) (D.C.)  \nAbstract: The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to single-drug treatments. Combining cisplatin with calcitrioland progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer. The effectiveness of vitamin derivatives in anticancer treatment may vary depending on the characteristics of the tumor and the cell line from which it originated. An increase in thiamine intake of one unit is associated with an 18% decrease in HPV infection. Higher intake of vitamin C by 50 mg/day is linked to a lower risk of cervical neoplasia. Beta-carotene, vitamin C, and vitamin E are associated with risk reductions of 12%, 15%, and 9% in endometrial cancer, respectively. A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitaminsand metabolic markers and clinical outcomes.  \nKeywords: retinoic acid; all-trans retinoic acid; 4-HPR; TAC-101; calcitriol; VDR; FR-α; FITC  \n1. Introduction  \nCancer is one of the leading causes of death among women in Europe. According to the findings of the European Cancer Information System, by 2040 the incidence of cancer among women will relatively increase by 14.79% compared to 2022 (Table 1) [1] . Among the most important reasons for this are demographic changes, such as an aging population. This increases the overall risk of cancer [1] . The incidence statistics may also be influenced by advances in diagnostics, allowing cancers to be detected at an earlier stage of development.  \nStrategies for preventing the development of gynecologic cancers include regular gynecologic check-ups, human papillomavirus (HPV) vaccination or physical activity anda healthy diet [2,3] . In the past two decades, many publications have focused attention on the role of micronutrients in the prevention of gynecologic malignancies [4–6] . Extensive meta-analyses have shown that daily supplementation with vitamin A and D3 can reduce the incidence of ovarian cancer [7–9], as well as mortality from malignant cancer by up to 12%[9] .  \nCurrently, only the vit","cbCaifzI15Yzo8xq","https://ap.wps.com/l/cbCaifzI15Yzo8xq","pdf",897217,17,"English","# Introduction\n## Cancer burden and prevention strategies\n## Micronutrients and vitamin supplementation\n# Methodology\n## Literature search and inclusion criteria","[{\"question\":\"How do vitamin A and D derivatives affect gynecologic malignancy treatment outcomes?\",\"answer\":\"The article reports that combining vitamin A and D derivatives with classical chemotherapy yields more satisfactory outcomes and can enhance anti-cancer effects in gynecologic malignancies.\"},{\"question\":\"What treatment combinations involving cisplatin and vitamins are discussed?\",\"answer\":\"It discusses combinations such as cisplatin with calcitriol and progesterone, which may increase VDR expression and potentially improve the effectiveness of anticancer therapy in ovarian cancer.\"},{\"question\":\"What observational links are described between vitamin intake and cervical or HPV-related outcomes?\",\"answer\":\"Higher thiamine intake is associated with an 18% decrease in HPV infection, and higher vitamin C intake (50 mg/day) is linked to a lower risk of cervical neoplasia.\"}]","Vitamins in Gynecologic Malignancies - Review | PDF",1790215856,43]