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This narrative review, developed within the Italian Society of Human Nutrition (SINU) oncology working group, examines the prevalence of vitamin malnutrition in pancreatic cancer patients. Literature synthesis indicates elevated risks of water-soluble vitamin deficiencies, especially B1, B3, and B6, and increased likelihood of fat-soluble vitamin deficiencies, with vitamin D linked to survival through plasma levels.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vitamin-nutritional-status-in-patients-with-pancreatic-cancer-a-narrative-review/339313/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vitamin-nutritional-status-in-patients-with-pancreatic-cancer-a-narrative-review/339313.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is nutrition important in pancreatic cancer care?","Question",{"text":112,"@type":113},"Nutrition is linked to improving outcomes of cancer treatment and may help alleviate suffering and support survival. 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Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review. Int. J. Mol. Sci. 2024, 25, 4773. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25094773](10.3390/ijms25094773)  \nAcademic Editor: Gabriella Calviello  \nReceived: 27 February 2024  \nRevised: 9 April 2024  \nAccepted: 24 April 2024  \nPublished: 27 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Council for Agricultural Research and Economics—Research Centre for Food and Nutrition,  \n00178 Rome, Italy; [angela.polito@crea.gov.it](angela.polito@crea.gov.it)  \n2 Department of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; [nutrizionefurini@gmail.com](nutrizionefurini@gmail.com) (T.F.); [gasperi@med.uniroma2.it](gasperi@med.uniroma2.it) (V.G.)  \n3 Department of Public Health, School of Medicine, Federico II University, 80131 Naples, Italy; scalfi@unina.it  \n4 Experimental Medicine Department, Food Science and Human Nutrition Research Unit,“Sapienza” University, 00185 Rome, Italy; [alessandro.pinto@uniroma1.it](alessandro.pinto@uniroma1.it)  \n* Correspondence: [elena.azzini@crea.gov.it](elena.azzini@crea.gov.it) (E.A.); [savini@uniroma2.it](savini@uniroma2.it) (I.S.)  \n† The members of SINU “Nutrition in Oncology”Working Group are listed at [https://eng.sinu.it/oncology/](https://eng.sinu.it/oncology/) .  \nAbstract: Due to the high mortality rate in Western countries, pancreatic cancer is considered one of the big killers, leaving patients and their families with little hope upon diagnosis. Although surgical and drug therapies are critical for cancer patients to improve life expectancy and alleviation of suffering, nutrition plays a key role in improving cancer treatment outcomes. This narrative review, conducted as part of the activities of the Italian Society of Human Nutrition (SINU) working group in oncology, focuses on the prevalence of vitamin malnutrition among pancreatic cancer patients. The results of the literature search show that pancreatic cancer patients are at a heightened risk of water-soluble vitamin deficiencies, particularly of vitamins B1, B3, and B6 . Additionally, they also face an increased risk of deficiency of fat-soluble vitamins. Among these vitamins, the potential role of vitamin D in pancreatic cancer has garnered the most attention, with its plasma levels being identified as a significant factor in patient survival. Investigating vitamin nutritional status could provide valuable insights for incorporating nutritional approaches into the prevention and treatment of pancreatic cancer, thereby reducing the exacerbation of symptoms associated with the diagnosis.  \nKeywords: pancreatic cancer; water-soluble vitamins; fat-soluble vitamins; vitamin nutritional status  \n1. Introduction  \nIn recent decades, the interest in the role of nutrition has become increasingly relevant, especially in the context of noncommunicable diseases (NCDs), including cancer. Although for cancer patients the main aspects concern surgical and pharmacological therapies, life expectancy, and alleviating suffering, nutrition plays a fundamental role in improving outcomes of oncological treatments. In fact, malnutrition is often underestimated and eve","cbCailDUJvekXavN","https://ap.wps.com/l/cbCailDUJvekXavN","pdf",1570399,14,"English","# Introduction\n# Vitamin Malnutrition Prevalence in Pancreatic Cancer Patients\n## Water-Soluble Vitamin Deficiencies\n## Fat-Soluble Vitamin Deficiencies and Vitamin D","[{\"question\":\"Why is nutrition important in pancreatic cancer care?\",\"answer\":\"Nutrition is linked to improving outcomes of cancer treatment and may help alleviate suffering and support survival. Malnutrition and micronutrient deficiencies are often present yet underestimated in patients.\"},{\"question\":\"Which vitamins show the highest deficiency risk in pancreatic cancer patients?\",\"answer\":\"The review highlights a heightened risk of water-soluble vitamin deficiencies, particularly vitamins B1, B3, and B6. It also reports increased risk for fat-soluble vitamin deficiencies.\"},{\"question\":\"What role does vitamin D play in pancreatic cancer outcomes?\",\"answer\":\"The review notes that vitamin D has garnered the most attention, with plasma vitamin D levels identified as a significant factor associated with patient survival.\"}]","Vitamin Nutritional Status in Patients with Pancreatic Cancer - A Narrative Review | PDF",1790029424,35]