[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436984-105":59,"doc-detail-436984-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","vitamin-d-and-systemic-lupus-erythematous-editorial","Vitamin D and systemic lupus erythematous - Editorial","","Editorial text discusses how vitamin D signaling via the vitamin D receptor (VDR) affects calcium/phosphate metabolism and broader gene-regulatory and immune-related functions, highlighting ongoing debate about supplementation benefits. It summarizes a May Journal of the Chinese Medical Association study on childhood-onset systemic lupus erythematosus (SLE) in Taiwan, focusing on vitamin D3 deficiency frequency and negative correlation with SLE disease activity. Additional commentary addresses steroid treatment effects, sex hormone bias considerations, and SLEDAI-2K limitations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vitamin-d-and-systemic-lupus-erythematous-editorial/436984/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vitamin-d-and-systemic-lupus-erythematous-editorial/436984.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological role of vitamin D is emphasized in the editorial?","Question",{"text":112,"@type":113},"The editorial highlights vitamin D’s action through the nuclear vitamin D receptor (VDR), regulating transcription and epigenomic effects that support calcium/phosphate metabolism and broader cellular, immune, and tissue functions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What key findings does the editorial attribute to the Taiwan pediatric SLE study?",{"text":117,"@type":113},"It reports that vitamin D3 deficiency is common in children with SLE and that serum vitamin D3 levels negatively correlate with SLE disease activity. Children receiving steroids showed significantly lower vitamin D3 levels than those without.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the editorial question the interpretation of the vitamin D3 results?",{"text":121,"@type":113},"It suggests potential bias from sex-hormone profiles because all boys in the study received steroid treatment and steroids can lower vitamin D3, while the number of boys was also small. It also notes concerns about the accuracy and responsiveness of SLEDAI-2K for detecting clinically meaningful changes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436984,1790778180,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nEDITORIAL  \nVitamin D and systemic lupus erythematous  \nWen-Ling Leea,b,c, Fa-Kung Leed,e, Peng-Hui Wangb,e,f,g,*  \naDepartment of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan, ROC; bInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cDepartment of Nursing, Oriental Institute of Technology, New Taipei City, Taiwan, ROC; dDepartment of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan, ROC; eFemale Cancer Foundation, Taipei, Taiwan, ROC; fDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; gDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC  \nVitamin D classically mediated its cognate nuclear vitamin D receptor (VDR, one of the nuclear receptors [NRs]) functioning asa steroid hormone to regular transcription as well as epigenomic effects is mainly responsible for the regulation of calcium and phosphate metabolism and for maintaining a healthy mineralized skeleton.1–3 Due to the wide expression of VDR and vitamin D metabolic enzymes in most tissues, serving as sensors of stimuli, mast regulators of downstream molecular events, and hubs governing complex gene regulatory networks, there are numerous genetic, molecular, cellular, and animal studies strongly suggesting that vitamin D signaling by regulating a wide array of genes may have many extra-skeletal effects, such as regulation of cell proliferation, immune and muscle function, skin differentiation, and reproduction, as well as vascular and metabolic properties.1–3 From observational studies in human subjects, poor vitamin D function, such as low level of vitamin D, dysfunction of VDR, and interference of interaction between vitamin D andVDR is actively involved in many aspects of human physiology and pathology.3–5 Additionally, reports from randomized controlled trials show the potential benefits of vitamin D supplementation on the reduction of incidence of many diseases,6–8 although evidence is still in debate.3,7,8 Therefore, any research focusing on the vitamin D3 and health/or disease is welcome. In the May issue of the Journal of the Chinese Medical Association, we are happy to learn the research addressing this type of problem (the correlation between vitamin D levels and the disease activity of childhood-onset systemic lupus erythematosus [SLE]) .9 Cheng et al9 tried to investigate whether the correlation between vitamin D3 levels and the  \ndisease activity of children with SLE is present in Taiwan.  \nThe authors recruited 31 children with SLE who were treated with either steroid and nonsteroid or combination regimens and found that vitamin D3 deficiency is common in children with SLE, and serum vitamin D3 levels negatively correlate to disease  \n* Address correspondence. Dr. Peng-Hui Wang, Department of Obstetricsand Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail addresses: phwang@vghtpe.gov.tw](ROC. E-mail addresses: phwang@vghtpe.gov.tw); [pongpongwang@gmail.com](pongpongwang@gmail.com) (P.-H. Wang)  \nConflicts of interest: Dr. Peng-Hui Wang, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 811-812.  \nReceived May 11, accepted May 13, 2022.  \ndoi: 10. 1097/JCMA.0000000000000746.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nactivity of SLE.9 Of most importance, the authors found that the children treated with steroids had a statistical","cbCaim4QIMVEb0kT","https://ap.wps.com/l/cbCaim4QIMVEb0kT","pdf",291802,"English","# Editorial\n## Vitamin D signaling and extra-skeletal effects\n## Summary of Cheng et al. study in childhood-onset SLE\n## Steroid treatment, sex hormone bias, and study interpretation\n## Disease activity measurement using SLEDAI-2K","[{\"question\":\"What biological role of vitamin D is emphasized in the editorial?\",\"answer\":\"The editorial highlights vitamin D’s action through the nuclear vitamin D receptor (VDR), regulating transcription and epigenomic effects that support calcium/phosphate metabolism and broader cellular, immune, and tissue functions.\"},{\"question\":\"What key findings does the editorial attribute to the Taiwan pediatric SLE study?\",\"answer\":\"It reports that vitamin D3 deficiency is common in children with SLE and that serum vitamin D3 levels negatively correlate with SLE disease activity. Children receiving steroids showed significantly lower vitamin D3 levels than those without.\"},{\"question\":\"Why does the editorial question the interpretation of the vitamin D3 results?\",\"answer\":\"It suggests potential bias from sex-hormone profiles because all boys in the study received steroid treatment and steroids can lower vitamin D3, while the number of boys was also small. It also notes concerns about the accuracy and responsiveness of SLEDAI-2K for detecting clinically meaningful changes.\"}]","Vitamin D and systemic lupus erythematous - Editorial | PDF",1790679675]