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Current evidence supports its rationale in autoimmune disorders and neoplastic diseases. A literature review evaluates vitamin C supplementation for benefits in diseases such as systemic lupus erythematosus and rheumatoid arthritis, and in hematological cancers. Mechanisms include cytokine microenvironment regulation, modulation of immune responses to autoantigens and tumor cells, and control of oxidative stress. It may also potentiate chemotherapy, radiotherapy, and targeted therapy, supporting integrative approaches as prevention and adjuvant care.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vitamin-c-supplementation-in-the-treatment-of-autoimmune-and-onco-hematological-diseases-from-prophylaxis-to-adjuvant-therapy-review/332222/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vitamin-c-supplementation-in-the-treatment-of-autoimmune-and-onco-hematological-diseases-from-prophylaxis-to-adjuvant-therapy-review/332222.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What main mechanisms explain how vitamin C may help in autoimmune and cancer conditions?","Question",{"text":112,"@type":113},"Vitamin C can regulate the cytokine microenvironment, modulate immune responses to autoantigens and cancer cells, and control oxidative stress. It also supports immune cell functions such as oxidative stress handling and cytokine modulation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which autoimmune diseases are highlighted as having potential benefits from vitamin C supplementation?",{"text":117,"@type":113},"The review discusses evidence for autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). It also references other autoimmune conditions in the discussion.",{"name":119,"@type":110,"acceptedAnswer":120},"How might vitamin C contribute as an adjuvant to cancer therapies?",{"text":121,"@type":113},"The article describes an enhanced effect of integrative vitamin C therapy on chemotherapies, ionizing radiation, and target therapy in treating hematological neoplasms. 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Vitamin C Supplementation in the Treatment of Autoimmune and  \nOnco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int.  \nJ. Mol. Sci. 2024, 25, 7284. [https://](https://)[ ](https://)[doi.org/10.3390/ijms25137284](doi.org/10.3390/ijms25137284)  \nAcademic Editor: Maria Valeria Catani  \nReceived: 28 May 2024  \nRevised: 29 June 2024  \nAccepted: 1 July 2024  \nPublished: 2 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 School and Operative Unit of Allergy and Clinical Immunology, Policlinico “G. Martino”, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy; [stefania.isola@unime.it](stefania.isola@unime.it) (S.I.); [gangemis@unime.it](gangemis@unime.it) (S.G.)  \n2 Provincial Healthcare Unit, Section of Allergy, 89900 Vibo Valentia, Italy; [fabianafurci@gmail.com](fabianafurci@gmail.com)  \n3 Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR),  \n98125 Messina, Italy; [giovanni.pioggia@cnr.it](giovanni.pioggia@cnr.it)  \n4 Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, 98100 Messina, Italy; alessandro.allegra@unime.it  \n* Correspondence: [lucagammeri@outlook.com](lucagammeri@outlook.com); Tel.: +39-090-2212-049 † These authors contributed equally to the work.  \nAbstract: Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory, immunoregulatory, and antioxidant activities. Today, this vitamin is integrated into the treatment of many inflammatory pathologies. However, there is increasing evidence of possible use in treating autoimmune and neoplastic diseases. We reviewed the literature to delve deeper into the rationale for using vitamin C in treating this type of pathology. There is much evidence in the literature regarding the beneficial effects of vitamin C supplementation for treating autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) and neoplasms, particularly hematological neoplastic diseases. Vitamin C integration regulates the cytokines microenvironment, modulates immune response to autoantigens and cancer cells, and regulates oxidative stress. Moreover, integration therapy has an enhanced effect on chemotherapies, ionizing radiation, and target therapy used in treating hematological neoplasm. In the future, integrative therapy will have an increasingly important role in preventing pathologies and as an adjuvant to standard treatments.  \nKeywords: vitamin C; autoimmunity; cancer; leukemia; multiple myeloma; lymphoma; dietary integration; micronutrient  \n1. Introduction  \nMany recent studies have reported the importance of vitamin C (ascorbic acid) for general health and its role in the pathogenesis of various diseases, considering its antioxidant activity and its effects on DNA demethylation. Vitamin C is a water-soluble vitamin obtained through the dietary intake of fruit and vegetables, initially identified as a factor in preventing scurvy disease [1] . Recently, it was recognized for its anti-inflammatory properties. Vitamin C improves immune functions by setting innate and adaptive immune responses, reduces cellular oxidative stress, and acts as a cofactor for several enzymatic reactions. Its pleiotropic use has b","cbCaip3EPfZtw3f8","https://ap.wps.com/l/cbCaip3EPfZtw3f8","pdf",1157513,27,"English","# Abstract\n# Introduction\n## Vitamin C in health and disease mechanisms\n## Vitamin C in autoimmune diseases\n## Vitamin C in cancer and tumor microenvironment","[{\"question\":\"What main mechanisms explain how vitamin C may help in autoimmune and cancer conditions?\",\"answer\":\"Vitamin C can regulate the cytokine microenvironment, modulate immune responses to autoantigens and cancer cells, and control oxidative stress. It also supports immune cell functions such as oxidative stress handling and cytokine modulation.\"},{\"question\":\"Which autoimmune diseases are highlighted as having potential benefits from vitamin C supplementation?\",\"answer\":\"The review discusses evidence for autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). It also references other autoimmune conditions in the discussion.\"},{\"question\":\"How might vitamin C contribute as an adjuvant to cancer therapies?\",\"answer\":\"The article describes an enhanced effect of integrative vitamin C therapy on chemotherapies, ionizing radiation, and target therapy in treating hematological neoplasms. It also notes vitamin C’s potential role in strengthening immune-mediated anti-tumor activity.\"}]","Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy - review | PDF",1789997414,68]