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Methods: retrospective review at a private clinic in Western Australia (July 2021–February 2023), comparing preoperative and 1-month postoperative data between two cohorts. Results: 50 procedures per system; exclusions reduced postoperative review samples. Total suction time averaged 34s (VisuMax 500) vs 13s (VisuMax 800); overall safety and refractive outcomes were similar. Conclusion: VisuMax 800 offers faster procedures with no significant safety differences; larger longer-term studies are needed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/visual-and-refractive-outcomes-of-myopic-lenticule-extraction-with-the-zeiss-visumax-500-and-800-systems-original-research-clinical-ophthalmology/420366/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/visual-and-refractive-outcomes-of-myopic-lenticule-extraction-with-the-zeiss-visumax-500-and-800-systems-original-research-clinical-ophthalmology/420366.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of comparing Zeiss VisuMax 800 and VisuMax 500 systems?","Question",{"text":112,"@type":113},"To compare visual outcomes, safety, and efficacy of myopic keratorefractive lenticule extraction using the newer VisuMax 800 system versus the VisuMax 500 system.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients and procedures selected for the study?",{"text":117,"@type":113},"A retrospective review included the last 50 myopic KLEx procedures using VisuMax 500 (group 1) and the first 50 using VisuMax 800 (group 2), with exclusion only for patients who did not return for the 1-month postoperative review.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key outcome differences reported between the two systems?",{"text":121,"@type":113},"The average total suction time was shorter with VisuMax 800 (13 seconds) than with VisuMax 500 (34 seconds), while visual and refractive outcomes and safety profiles were similar with no significant differences.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},420366,1790669137,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Clinical Ophthalmology  \n Open Access Full Text Article  \nORIGINAL RESEARCH  \nVisual and Refractive Outcomes of Myopic Lenticule Extraction with the Zeiss VisuMax 500 and 800 Systems  \nJonathan Philip Chung , Robert Andrew Paul  WA Laser Eye Centre, Alfred Cove, Western Australia, 6154, Australia  \nCorrespondence: Jonathan Philip Chung, WA Laser Eye Centre, Suite 1/533 Canning Hwy, Alfred Cove, Western Australia, 6154, Australia,  \nEmail [drjonathanchung@gmail.com](drjonathanchung@gmail.com)  \n\n| Purpose: This study aimed to compare the visual outcomes, safety and efficacy of myopic keratorefractive lenticule extraction treatments using the newer Zeiss VisuMax 800 system over its precursor, the VisuMax 500 system.\u003Cbr>Patients and Methods: A retrospective review conducted at a private clinic in Western Australia of myopic keratorefractive lenticule extraction treatments with the VisuMax 500 and the VisuMax 800 systems between July 2021 and February 2023. Preoperative and 1-month post-operative data were compared between the two cohorts. Demographics, best corrected visual acuity, uncorrected distance visual acuity, mean refractive spherical equivalent, total suction time and complications were recorded. Results: Fifty procedures for each system were identified. Eight eyes in the VisuMax 500 cohort (group 1) and five eyes in the VisuMax 800 cohort (group 2) were excluded due to non-attendance at the 1-month post-operative review. The average total suction time was 34 seconds vs 13 seconds respectively. A single case of suction loss occurred in group 1. The mean pre-operative mean refractive spherical equivalent of groups 1 and 2 were −6.02D (−3.63 to −9.00) and −5.56D (−2.75 to −8.88) (P = 0.20) . The mean post-operative mean refractive spherical equivalent of the two groups were 0.08D (−1.00 to 1.25) and −0.03D (−2.25 to 1.00) (P = 0.31) .\u003Cbr>Conclusion: The VisuMax 500 and 800 systems have similar visual outcomes and no significant difference in safety profiles. The main advantage of the newer VisuMax 800 femtosecond laser is its speed and potential for less cases of suction loss. Larger studies over longer terms are required.\u003Cbr>Keywords: KLEx, myopia, laser |\n| --- |\n| Introduction\u003Cbr>Keratorefractive lenticule extraction (KLEx) is the latest term to describe lenticule extraction procedures with the aim of refractive correction.1 Carl Zeiss Meditec AG introduced small incision lenticule extraction (SMILE) in 2011, a term to describe their proprietary effort in advancing refractive lenticule extraction procedures using their femtosecond laser.2 SMILE falls within the KLEx spectrum and involves the use of a femtosecond laser that can cut an intrastromal refractive lenticule within the cornea which is then removed manually via a small 3.0 to 5.0mm corneal incision.3 This process achieves corneal reshaping with the typical goal of correcting a patient’s myopia or myopic astigmatism. The benefits of SMILE have been well described. Clinically, SMILE has advantages over the more traditional laser in situ keratomileusis (LASIK) with studies indicating less rates of post-operative dry eye, better spherical aberration control, potentially biomechanically more stable corneas and no risk offlap complications.4–6 Practically, SMILE requires only a single laser compared to the well-known bimodal solution of LASIK.7\u003Cbr>Given the increasing popularity of SMILE and the release of a newer model of the femtosecond laser (VisuMax 800, Carl Zeiss Meditec AG, Jena, Germany), we decided to compare this newer laser with the previous model (VisuMax 500, Carl Zeiss Meditec AG, Jena, Germany) .8 |\n\nReceived: 10 August 2025  \nAccepted: 19 December 2025  \nPublished: 30 December 2025  \nClinical Ophthalmology 2025:19 4951–4956 4951  \n© 2025 Chung and Paul. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at [https://www.dovepress.com/](https://www.dovepress.com/)  \nterms.php and incorporate th","cbCaib3J2sQZOv3D","https://ap.wps.com/l/cbCaib3J2sQZOv3D","pdf",1872178,"English","# Introduction\n## Keratorefractive lenticule extraction (KLEx) and SMILE background\n## Rationale for comparing VisuMax 800 vs VisuMax 500\n# Materials and Methods\n## Study approval and ethics\n## Patient selection\n## Pre-operative assessment","[{\"question\":\"What is the main goal of comparing Zeiss VisuMax 800 and VisuMax 500 systems?\",\"answer\":\"To compare visual outcomes, safety, and efficacy of myopic keratorefractive lenticule extraction using the newer VisuMax 800 system versus the VisuMax 500 system.\"},{\"question\":\"How were patients and procedures selected for the study?\",\"answer\":\"A retrospective review included the last 50 myopic KLEx procedures using VisuMax 500 (group 1) and the first 50 using VisuMax 800 (group 2), with exclusion only for patients who did not return for the 1-month postoperative review.\"},{\"question\":\"What were the key outcome differences reported between the two systems?\",\"answer\":\"The average total suction time was shorter with VisuMax 800 (13 seconds) than with VisuMax 500 (34 seconds), while visual and refractive outcomes and safety profiles were similar with no significant differences.\"}]","Visual and Refractive Outcomes of Myopic Lenticule Extraction with the Zeiss VisuMax 500 and 800 Systems - ORIGINAL RESEARCH - Clinical Ophthalmology | PDF",1790620695,15]