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Current diagnostic approaches lack specificity and sensitivity, motivating the search for earlier detection tools. Vibrational spectroscopy (VS) offers a promising route for early diagnosis. This review summarizes recent spectroscopic methodology improvements, clarifies strengths and limitations, and highlights spectroscopic data evaluation using multivariate analysis and convolutional neural networks, ending with a study design for systematic verification.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vibrational-spectroscopy-are-we-close-to-finding-a-solution-for-early-pancreatic-cancer-diagnosis/378597/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vibrational-spectroscopy-are-we-close-to-finding-a-solution-for-early-pancreatic-cancer-diagnosis/378597.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early pancreatic cancer diagnosis difficult?","Question",{"text":112,"@type":113},"Early PC detection lacks specific and sensitive diagnostic options, leading to late-stage disease at diagnosis. Morphological and molecular tumor heterogeneity and variability also complicate assessment and response prediction.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does vibrational spectroscopy (VS) play in early PC detection?",{"text":117,"@type":113},"VS is presented as having a promising role in developing early diagnosis technology for pancreatic cancer. The review discusses recent improvements in VS-based methodologies and how they may support earlier identification.",{"name":119,"@type":110,"acceptedAnswer":120},"How are spectroscopic data analyzed in the proposed approaches?",{"text":121,"@type":113},"Spectroscopic data evaluation is addressed using multivariate analysis and convolutional neural network methodology. These approaches are used to improve interpretation of spectroscopic signals for diagnostic purposes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378597,1790662100,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com)  \n[DOI:](DOI: 10.3748/wjg.v29.i1.96)[ 10.3748/wjg.v29.i1.96](DOI: 10.3748/wjg.v29.i1.96)  \nWorld J Gastroenterol 2023 January 7; 29(1): 96-109 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nMINIREVIEWS  \nVibrational spectroscopy – are we close to finding a solution for early pancreatic cancer diagnosis?  \nKrzysztof Szymoński, Łukasz Chmura, Ewelina Lipiec, Dariusz Adamek  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Susak YM, Ukraine; Zhao CF, China  \nReceived: July 8, 2022  \nPeer-review started: July 8, 2022  \nFirst decision: September 26, 2022  \nRevised: October 3, 2022  \nAccepted: October 31, 2022  \nArticle in press: October 31, 2022  \nPublished online: January 7, 2023  \nKrzysztof Szymoński, Łukasz Chmura, Department of Pathomorphology, Jagiellonian University Medical College, Cracow 33-332, Poland  \nKrzysztof Szymoński, Łukasz Chmura, Dariusz Adamek, Department of Pathomorphology, University Hospital in Cracow, Cracow 31-501, Poland  \nEwelina Lipiec, M. Smoluchowski Institute of Physics, Jagiellonian University, Cracow 30-348, Poland  \nDariusz Adamek, Department of Neuropathology, Jagiellonian University Medical College, Cracow 33-332, Poland  \nCorresponding author: Krzysztof Szymoński, MD, Academic Research, Doctor, Researcher, Senior Researcher, Teaching Assistant, Department of Pathomorphology, Jagiellonian University Medical College, Grzegórzecka 16, Cracow 33-332, Poland.  \n[krzysztof.szymonski@uj.edu.pl](krzysztof.szymonski@uj.edu.pl)  \nAbstract  \nPancreatic cancer (PC) is an aggressive and lethal neoplasm, ranking seventh in the world for cancer deaths, with an overall 5-year survival rate of below 10% . The knowledge about PC pathogenesis is rapidly expanding. New aspects of tumor biology, including its molecular and morphological heterogeneity, have been reported to explain the complicated “cross-talk” that occurs between the cancer cells and the tumor stroma or the nature of pancreatic ductal adenocarcinoma-associated neural remodeling. Nevertheless, currently, there are no specific and sensitive diagnosis options for PC. Vibrational spectroscopy (VS) shows a promising role in the development of early diagnosis technology. In this review, we summarize recent reports about improvements in spectroscopic methodologies, briefly explain and highlight the drawbacks of each of them, and discuss available solutions. The important aspects of spectroscopic data evaluation with multivariate analysis and a convolutional neural network methodology are depicted. We conclude by presenting a study design for systemic verification of the VS-based methods in the diagnosis of PC.  \nKey Words: Spectroscopic cancer diagnosis; Raman spectroscopy; Pancreatic cancer diagnosis; DNA methylation; Liquid biopsy biomarkers; Convolutional neural networks  \n©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 96 January 7, 2023  Volume 29  Issue 1   \nSzymoński K et al. Solution for early pancreatic cancer PC diagnosis  \nCore Tip: Vibrational spectroscopy (VS) may become a major player in the development of early diagnosis technology for pancreatic cancer. As with every technique, VS has promising attributes as well as drawbacks. We summarize recent reports about improvements in spectroscopic methodologies, briefly explain and highlight the drawbacks of each of them, and discuss available solutions. Additionally, the important aspects of spectroscopic data evaluation with multivariate analysis and a convo","cbCaiebQ1KmxOnrt","https://ap.wps.com/l/cbCaiebQ1KmxOnrt","pdf",6544486,15,"English","# Introduction\n# Early Diagnosis of PC","[{\"question\":\"Why is early pancreatic cancer diagnosis difficult?\",\"answer\":\"Early PC detection lacks specific and sensitive diagnostic options, leading to late-stage disease at diagnosis. Morphological and molecular tumor heterogeneity and variability also complicate assessment and response prediction.\"},{\"question\":\"What role does vibrational spectroscopy (VS) play in early PC detection?\",\"answer\":\"VS is presented as having a promising role in developing early diagnosis technology for pancreatic cancer. The review discusses recent improvements in VS-based methodologies and how they may support earlier identification.\"},{\"question\":\"How are spectroscopic data analyzed in the proposed approaches?\",\"answer\":\"Spectroscopic data evaluation is addressed using multivariate analysis and convolutional neural network methodology. These approaches are used to improve interpretation of spectroscopic signals for diagnostic purposes.\"}]","Vibrational spectroscopy - are we close to finding a solution for early pancreatic cancer diagnosis? | PDF",1790231372,38]