[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-216932-en":3,"doc-seo-216932-105":30,"detail-sidebar-cat-0-en-105":97},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},216932,687207024643,"Rhys","https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2",7,"Healthcare","Vestibular Evaluation Using Videonystagmography of Chronic Zinc Deficient Patients Due to Short Bowell Syndrome - Research Findings","Vestibular dysfunction in chronic zinc deficiency associated with short bowel syndrome is examined through retrospective clinical assessment. Serum zinc levels are measured in nine patients with chronic zinc deficiency, who then undergo videonystagmography; outcomes are compared with a control group of seven subjects without auditory or vestibular complaints. All vestibular test parameters show altered results versus controls, supporting significant group differences. Findings highlight zinc’s potential role in vestibular disorder genesis and warrant attention to hypozincemia’s effects on vestibular function.","Vestibular Evaluation Using Videonystagmography of Chronic Zinc Deficient Patients Due to Short Bowell Syndrome  \nGustavo Duarte Paiva Ferreira1, Maria Cristina Lancia Cury2, José Antônio de Oliveira3, Alessandra Kerli Manfredi4, Hélio Vannucchi5  \nKeywords: bowel, labyrinth, nystagmus, dizziness, thrombosis,  \nzinc.  \nSummary  \naeblpresencee participaof zintion inctiinnntihtues aaundditoryhearipangtlhowssayasre aknndoiwtsn facts, although there are no clinical trials and experimental studies showing the impact of hypozincemia in the vestibular system and zinc existence in the vestibular pathway, respectively. Aim: This study is an attempt to correlate hypozincemia and abnormal vestibular function. Methods: This is a clinical retrospective case study where nine patients suffering of chronic zinc deficiency had their serum zinc determined and were submitted to videonystagmography. Results were compared to a normal (control) group. Results: All vestibular test parameters were altered when we compared experimental and control groups. Conclusion: Comparison between groups shows significant differences in many aspects of the vestibular analysis and calls our attention towards a possible participation of zinc on the genesis of vestibular disorders.  \n1 Master’s degree, assistant physician of the Núcleo de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço de São Paulo.  \n2 Habilitation degree, assistant professor of the Departamento de Otorrinolaringologia, Oftalmologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto-USP.  \n3 Habilitation degree, full professor of the Departamento de Otorrinolaringologia, Oftalmologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto-USP.  \n4 Doctoral degree, speech therapist of the Setor de Fonoaudiologia, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-USP.  \n5 Habilitation degree, Head of the Unidade Metabólica, Faculdade de Medicina de Ribeirão Preto-USP.  \nFaculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  \nAddress for correspondence: Rua Camilo 173 ap.11 Vila Romana São Paulo SP 05045-020.  \nCAPES.  \nThis paper was submitted to the RBORL-SGP (Publishing Manager System) on 7 December 2007. Code 5612.  \nThe article was accepted on 29 July 2008.  \nBRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY 75 (2) MARCH/APRIL 2009  \n[http://www.rborl.org.br / e-mail:](http://www.rborl.org.br / e-mail:) [revista@aborlccf.org.br](revista@aborlccf.org.br)  \n290  \n\n| INTRODUCTION |\n| --- |\n| The physiological role of the zinc ion in the central nervous system (CNS) is not fully understood. Since the neural pathways in which zinc was found are glutamatergic, and knowing that zinc inhibits the binding of glutamate to its receptors, it is thought that this ion modulates the glutamatergic synapses.¹\u003Cbr>In 1981, zinc was found in the cochlear nuclei.\u003Cbr>Many authors have correlated zinc physiology with the onset of tinnitus.3-5 Systemic administration of zinc has been suggested as an alternative therapy for treating this condition.6-9 Zinc also has a role in the structure of carbonic anhydrase,10 which removes free radicals in the vascular stria of the cochlea. Hypozincemia may alter the effect of this enzyme on carbon dioxide metabolism in the cochlea.\u003Cbr>The participation of zinc in calcium channels and the sodium-potassium pump was described in 1983.11 This pump is controlled by Na-K-ATPase and inhibited by zinc. Consequently, zinc deficiency may change the endocochlear potential, altering cochlear electrophysiology and generating tinnitus.\u003Cbr>Changes in zinc concentration may affect the structure and function of hair cells.12 These authors have shown that giving ototoxic doses of gentamicin causes decreased hearing, a significant increase in perilymphatic zinc content, and decreased serum levels of zinc.\u003Cbr>Zinc-rich diets are effective in preventing ototoxicity due to cadmium, which is the most toxic of heavy metals.13\u003Cbr>There is slower ","cbCaigtIvCyx70oj","https://ap.wps.com/l/cbCaigtIvCyx70oj","pdf",68159,1,5,"English","en",105,"# Introduction\n## Objective\n## Material and Method","[{\"question\":\"What is the study aiming to determine?\",\"answer\":\"The study aims to establish whether non-isolated chronic zinc deficiency is related to altered vestibular system function.\"},{\"question\":\"How were patients selected and compared?\",\"answer\":\"The experimental group included nine subjects with malabsorption due to short bowel syndrome after intestinal resection, and the control group included seven subjects without auditory or vestibular complaints. Strict exclusion criteria were applied to both groups.\"},{\"question\":\"What tests were used to assess vestibular function?\",\"answer\":\"Subjects underwent otoneurological evaluation including physical examination, voice and pure tone audiometry, impedance testing, and videonystagmography; serum zinc and magnesium levels were also measured before supplementation.\"}]","Vestibular Evaluation Using Videonystagmography of Chronic Zinc Deficient Patients Due to Short Bowell Syndrome - Research Findings | PDF",1788828408,13,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":92,"head_meta":94,"extra_data":96,"updated_unix":28},"vestibular-evaluation-using-videonystagmography-of-chronic-zinc-deficient-patients-due-to-short-bowell-syndrome-research-findings","",{"@graph":36,"@context":91},[37,54,74],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/vestibular-evaluation-using-videonystagmography-of-chronic-zinc-deficient-patients-due-to-short-bowell-syndrome-research-findings/216932/",4,{"url":52,"name":13,"@type":55,"image":56,"author":61,"headline":13,"publisher":63,"fileFormat":66,"inLanguage":23,"description":14,"dateModified":67,"datePublished":68,"encodingFormat":66,"isAccessibleForFree":69,"interactionStatistic":70},"DigitalDocument",{"url":57,"@type":58,"width":59,"height":60},"https://docshare.wps.com/thumbnails/vestibular-evaluation-using-videonystagmography-of-chronic-zinc-deficient-patients-due-to-short-bowell-syndrome-research-findings/216932.png","ImageObject",300,407,{"name":9,"@type":62},"Person",{"url":41,"name":64,"@type":65},"DocShare","Organization","application/pdf","2026-09-11","2026-09-08",true,{"@type":71,"interactionType":72,"userInteractionCount":20},"InteractionCounter",{"@type":73},"ViewAction",{"@type":75,"mainEntity":76},"FAQPage",[77,83,87],{"name":78,"@type":79,"acceptedAnswer":80},"What is the study aiming to determine?","Question",{"text":81,"@type":82},"The study aims to establish whether non-isolated chronic zinc deficiency is related to altered vestibular system function.","Answer",{"name":84,"@type":79,"acceptedAnswer":85},"How were patients selected and compared?",{"text":86,"@type":82},"The experimental group included nine subjects with malabsorption due to short bowel syndrome after intestinal resection, and the control group included seven subjects without auditory or vestibular complaints. Strict exclusion criteria were applied to both groups.",{"name":88,"@type":79,"acceptedAnswer":89},"What tests were used to assess vestibular function?",{"text":90,"@type":82},"Subjects underwent otoneurological evaluation including physical examination, voice and pure tone audiometry, impedance testing, and videonystagmography; serum zinc and magnesium levels were also measured before supplementation.","https://schema.org",{"og:url":52,"og:type":93,"og:title":13,"og:site_name":64,"og:description":14},"article",{"robots":95,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":98},[99,103,107,111,115,120,123,128,133,136,140],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":100,"show_sort_weight":101,"slug":102},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":104,"show_sort_weight":105,"slug":106},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},"Exam",70,"exam",{"id":21,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},"Comic",60,"comic",{"id":116,"doc_module":4,"doc_module_name":46,"category_name":117,"show_sort_weight":118,"slug":119},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":121,"slug":122},40,"healthcare",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},8,"Research & Report",30,"research-report",{"id":129,"doc_module":4,"doc_module_name":46,"category_name":130,"show_sort_weight":131,"slug":132},9,"Religion & Spirituality",20,"religion-spirituality",{"id":131,"doc_module":4,"doc_module_name":46,"category_name":134,"show_sort_weight":131,"slug":135},"World Cup","world-cup",{"id":137,"doc_module":4,"doc_module_name":46,"category_name":138,"show_sort_weight":137,"slug":139},10,"Lifestyle","lifestyle",{"id":141,"doc_module":4,"doc_module_name":46,"category_name":142,"show_sort_weight":21,"slug":143},19,"General","general"]