[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-606660-105":59,"doc-detail-606660-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","ventilator-induced-diaphragm-dysfunction-phenomenology-and-mechanisms-of-pathogenesis","Ventilator-induced diaphragm dysfunction: phenomenology and mechanism(s) of pathogenesis","","Mechanical ventilation (MV) supports breathing and gas exchange during critical illness and surgery, but can trigger rapid diaphragmatic atrophy and contractile dysfunction. This MV-induced weakness is termed ventilator-induced diaphragm dysfunction (VIDD) and contributes to failure to wean from MV, increasing hospitalization, morbidity, and mortality. Investigations show that enhanced mitochondrial reactive oxygen species production in diaphragm fibres drives redox-regulated signalling, accelerating proteolysis while suppressing protein synthesis, culminating in atrophy and impaired contractility.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ventilator-induced-diaphragm-dysfunction-phenomenology-and-mechanisms-of-pathogenesis/606660/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ventilator-induced-diaphragm-dysfunction-phenomenology-and-mechanisms-of-pathogenesis/606660.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-16",true,{"@type":101,"interactionType":102,"userInteractionCount":4},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is ventilator-induced diaphragm dysfunction (VIDD)?","Question",{"text":111,"@type":112},"VIDD is the rapid development of diaphragmatic atrophy and contractile dysfunction that can occur as an unintended side-effect of mechanical ventilation.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Why is VIDD clinically important?",{"text":116,"@type":112},"Diaphragmatic weakness from VIDD is a risk factor for failure to wean patients off ventilator support, leading to prolonged hospitalization and higher morbidity and mortality.",{"name":118,"@type":109,"acceptedAnswer":119},"What mechanisms drive the pathogenesis of VIDD?",{"text":120,"@type":112},"The review links VIDD to increased mitochondrial production of reactive oxygen species, which activates redox-regulated signalling that increases proteolysis and depresses protein synthesis, promoting atrophy and contractile dysfunction.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},606660,1792185604,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":128,"read_time":26},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","The Journal of Physiology  \nJ Physiol 602. 19 (2024) pp 4729–4752 4729  \nTOPICAL REVIEW  \nVentilator-induced diaphragm dysfunction:  \nphenomenology and mechanism(s) of pathogenesis  \nScott K. Powers   \nDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA  \nHandling Editor: Laura Bennet & Ken O’Halloran  \nThe peer review history is available in the Supporting Information section of this article ([https://doi.org/10.1113/JP283860\\#support-information-section](https://doi.org/10.1113/JP283860#support-information-section)).  \nAbstract Mechanical ventilation (MV) is used to support ventilation and pulmonary gas exchange in patients during critical illness and surgery. Although MV is a life-saving intervention for patients in respiratory failure, an unintended side-effect of MV is the rapid development of diaphragmatic atrophy and contractile dysfunction. This MV-induced diaphragmatic weakness is labelled as ‘ventilator-induced diaphragm dysfunction’(VIDD) . VIDD is an important clinical problem because diaphragmatic weakness is a risk factor for the failure to wean patients from MV. Indeed, the inability to remove patients from ventilator support results in prolonged hospitalization and increased morbidity and mortality. The pathogenesis of VIDD has been extensively investigated, revealing that increased mitochondrial production of reactive oxygen species within diaphragm muscle fibres promotes a cascade of redox-regulated signalling events leading to both accelerated proteolysis and depressed protein synthesis. Together, these events promote the rapid development of diaphragmatic atrophy and contractile dysfunction. This review highlights the MV-induced changes in the structure/function of diaphragm muscle  \nScott K. Powers is a professor emeritus of the University of Florida (Gainesville, Florida, USA) . Professor Powers earned his PhD in physiology at Louisiana State University and completed his postdoctoral training at the University of California-Santa Barbara. His research focuses on redox signalling in both cardiac and skeletal muscles with a specific focus on the mechanisms responsible for ventilator-induced diaphragm dysfunction.  \n© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society. DOI: 10 . 1113/JP283860  \n4730 S. K. Powers J Physiol 602.19  \nand discusses the cell-signalling mechanisms responsible for the pathogenesis of VIDD. This report concludes with a discussion of potential therapeutic opportunities to prevent VIDD and suggestions for future research in this exciting field.  \n(Received 3 March 2024; accepted after revision 12 August 2024; first published online 31 August 2024) Corresponding author S. K. Powers: Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32080, [USA. Email: spowers@hhp.ufl.edu](USA. Email: spowers@hhp.ufl.edu)  \nAbstract figure legend Prolonged mechanical ventilation results in diaphragmatic inactivity and a rapid increase in the production of reactive oxygen species (ROS) in mitochondria within diaphragm fibres. This rapid increase in mitochondrial ROS production results in disrupted redox signalling, leading to increased proteolysis and depressed protein synthesis. Together, these changes promote diaphragmatic atrophy and contractile dysfunction leading to diaphragmatic weakness. Notably, diaphragmatic weakness is a risk factor for difficulties in weaning patients from the ventilator.  \nIntroduction  \nMechanical ventilation (MV) is an important clinical tool used to maintain adequate pulmonary gas exchange in patients unable to do so on their own. Common indications for MV include critical illness-induced respiratory failure, neuromuscular disorders and surgery (Tobin, 2001) . Although MV is often a life-saving intervention for many patients, ≥18 h of MV results in the rapid development of diaphragmatic weakness due to both fibre atrophy and contractile dysfunction. Collectively, this","cbCaipdx1L8jiQ99","https://ap.wps.com/l/cbCaipdx1L8jiQ99","pdf",2567377,24,"English","# Introduction\n## Historical overview of VIDD\n# Mechanistic basis and cell-signalling pathways\n## Potential therapeutic opportunities\n## Future research directions","[{\"question\":\"What is ventilator-induced diaphragm dysfunction (VIDD)?\",\"answer\":\"VIDD is the rapid development of diaphragmatic atrophy and contractile dysfunction that can occur as an unintended side-effect of mechanical ventilation.\"},{\"question\":\"Why is VIDD clinically important?\",\"answer\":\"Diaphragmatic weakness from VIDD is a risk factor for failure to wean patients off ventilator support, leading to prolonged hospitalization and higher morbidity and mortality.\"},{\"question\":\"What mechanisms drive the pathogenesis of VIDD?\",\"answer\":\"The review links VIDD to increased mitochondrial production of reactive oxygen species, which activates redox-regulated signalling that increases proteolysis and depresses protein synthesis, promoting atrophy and contractile dysfunction.\"}]","Ventilator-induced diaphragm dysfunction: phenomenology and mechanism(s) of pathogenesis | PDF"]