[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378732-105":59,"doc-detail-378732-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","vascular-progenitor-cells-from-cancer-to-tissue-repair","Vascular Progenitor Cells: From Cancer to Tissue Repair","","Vascular progenitor cells are activated to repair and rebuild vascular tissue after damage caused by hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancer lesions, metastases, and catheter interventions. These cells regulate vascular lesion resolution and also support adult neovascularization and angiogenesis sprouting, often linked to carcinogenesis. The review examines the biology, cellular plasticity, and pathophysiology of vascular progenitor types, detailing their sources, stimuli, and activated differentiation pathways, with emphasis on tumor-induced vascular injury and the resulting promotion of tumor angiogenesis during proliferation and migration.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/vascular-progenitor-cells-from-cancer-to-tissue-repair/378732/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/vascular-progenitor-cells-from-cancer-to-tissue-repair/378732.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What causes vascular progenitor cells to become activated?","Question",{"text":113,"@type":114},"They are activated after vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions, metastases, and catheter interventions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do vascular progenitor cells influence cancer progression?",{"text":118,"@type":114},"They support angiogenesis and neovascularization, which can favor metastasis formation and survival and progression of tumors.",{"name":120,"@type":111,"acceptedAnswer":121},"What topics does the review cover about vascular progenitor cells?",{"text":122,"@type":114},"It discusses their biology, cellular plasticity, pathophysiology, including their origins (sources), stimuli, and activated pathways that drive differentiation, isolation, and characterization.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378732,1790493829,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review  \nVascular Progenitor Cells: From Cancer to Tissue Repair  \nSerena Barachini 1, Sandra Ghelardoni 2 and Rosalinda Madonna 3, *  \nCitation: Barachini, S.; Ghelardoni, S.; Madonna, R. Vascular Progenitor Cells: From Cancer to Tissue Repair.  \nJ. Clin. Med. 2023, 12, 2399. [https://](https://)[ ](https://)[doi.org/10.3390/jcm12062399](doi.org/10.3390/jcm12062399)  \nAcademic Editor: Yoshihiro Fukumoto  \nReceived: 15 February 2023  \nRevised: 12 March 2023  \nAccepted: 19 March 2023  \nPublished: 20 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratory for Cell Therapy, Department of Clinical and Experimental Medicine, University of Pisa,  \n56126 Pisa, Italy  \n2 Laboratory of Biochemistry, Department of Pathology, University of Pisa, 56126 Pisa, Italy  \n3 Department of Pathology, Cardiology Division, University of Pisa, 56126 Pisa, Italy  \n* Correspondence: [rosalinda.madonna@unipi.it](rosalinda.madonna@unipi.it); Tel.: +39-0502212111  \nAbstract: Vascular progenitor cells are activated to repair and form a neointima following vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions and metastases as well as catheter interventions. They play a key role not only in the resolution of the vascular lesion but also in the adult neovascularization and angiogenesis sprouting (i.e., the growth of new capillaries from pre-existing ones), often associated with carcinogenesis, favoring the formation of metastases, survival and progression of tumors. In this review, we discuss the biology, cellular plasticity and pathophysiology of different vascular progenitor cells, including their origins (sources), stimuli and activated pathways that induce differentiation, isolation and characterization. We focus on their role in tumor-induced vascular injury and discuss their implications in promoting tumor angiogenesis during cancer proliferation and migration.  \nKeywords: vascular progenitor cells; angiogenesis; cancer; metastasis  \n1. Introduction  \nWhen a vessel wall is injured, an intricate reconstitution process is triggered to repair and form a neointima. In this process, a leading role is played by vascular progenitor cells. Pericytes, mesenchymal stem cells, endothelial (EPCs) and smooth muscle progenitor cells (SMPCs) are a type of undifferentiated cells that are activated in the regeneration and replenishment upon vascular injury [1] . The organization of the vascular wall is well structured and consists of three different main functional layers: the intima, a single layer of endothelial cells, which provides an interface between blood and smooth muscle and contains vascular stem cells which are CD34 and c-kit-positive; the media, including smooth muscle cells, collagen and elastin; and the adventitia composed of undifferentiated dendritic cells, connective tissue, vasa vasorum and other cells including fibroblasts, pericytes, and cells CD34, Sca-1, c-kit, NG2 and GII1-positive. This well-organized vascular structure can deal with injuries that are often caused by several acute and chronic diseases including hypertension [2], atherosclerosis [3], diabetes [4,5], trauma [6], occlusions [7], hypoxia [8], primary cancerous lesions, and metastases [9] as well as catheter interventions [10,11] .  \nTo resolve the vascular damage, the progenitor cells are mobilized in the injured area and then they begin to differentiate and form a new vascular wall, with the aim of reorganizing themself into a new intima layer, the neointima [1,12] . The process is affected and regulated by the microenvironment, which maintains the dynamic equilibrium around the vessels: nerve fibers, adip","cbCaidAieGbaUOLu","https://ap.wps.com/l/cbCaidAieGbaUOLu","pdf",1131972,"English","# Introduction\n## Vascular injury and neointima formation\n## Microenvironmental regulation and tumor-related angiogenesis\n# Vascular Progenitor Cells","[{\"question\":\"What causes vascular progenitor cells to become activated?\",\"answer\":\"They are activated after vascular damage such as hypertension, atherosclerosis, diabetes, trauma, hypoxia, primary cancerous lesions, metastases, and catheter interventions.\"},{\"question\":\"How do vascular progenitor cells influence cancer progression?\",\"answer\":\"They support angiogenesis and neovascularization, which can favor metastasis formation and survival and progression of tumors.\"},{\"question\":\"What topics does the review cover about vascular progenitor cells?\",\"answer\":\"It discusses their biology, cellular plasticity, pathophysiology, including their origins (sources), stimuli, and activated pathways that drive differentiation, isolation, and characterization.\"}]","Vascular Progenitor Cells: From Cancer to Tissue Repair | PDF",1790232126,48]