[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-379861-105":3,"detail-sidebar-cat-0-en-105":79,"doc-detail-379861-en":129},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":72,"head_meta":74,"extra_data":76,"updated_unix":78},105,"en","value-of-apparent-diffusion-coefficient-on-mri-for-prediction-of-histopathological-type-in-anal-fistula-cancer","Value of apparent diffusion coefficient on MRI for prediction of histopathological type in anal fistula cancer","","Anal fistula cancer histopathology most commonly presents as mucinous adenocarcinoma or tubular adenocarcinoma. This retrospective observational study evaluated whether the apparent diffusion coefficient (ADC) on 1.5-T MRI can determine histopathological type and relate ADC values to clinical information and surgical-pathologic findings. Among 25 eligible male patients, ADC differed significantly between mucinous and tubular tumors and between Tis–T1–T2 and T3–T4 stages, supporting ADC-based prediction of type and depth.",{"@graph":14,"@context":71},[15,34,54],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/value-of-apparent-diffusion-coefficient-on-mri-for-prediction-of-histopathological-type-in-anal-fistula-cancer/379861/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":48,"encodingFormat":47,"isAccessibleForFree":49,"interactionStatistic":50},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/value-of-apparent-diffusion-coefficient-on-mri-for-prediction-of-histopathological-type-in-anal-fistula-cancer/379861.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-24",true,{"@type":51,"interactionType":52,"userInteractionCount":4},"InteractionCounter",{"@type":53},"ViewAction",{"@type":55,"mainEntity":56},"FAQPage",[57,63,67],{"name":58,"@type":59,"acceptedAnswer":60},"What is the purpose of measuring ADC on MRI in anal fistula cancer?","Question",{"text":61,"@type":62},"To evaluate whether the apparent diffusion coefficient (ADC) on MRI can predict the histopathological type of anal fistula cancer and assess relationships with clinical information and surgical findings.","Answer",{"name":64,"@type":59,"acceptedAnswer":65},"How was the study designed and how many patients were analyzed?",{"text":66,"@type":62},"This was a retrospective observational study. Of 69 diagnosed patients, 25 met the criteria and were selected for the final analysis using the same 1.5-T MRI machine and obtaining pathological samples at surgery.",{"name":68,"@type":59,"acceptedAnswer":69},"What differences in ADC were reported between tumor types and stages?",{"text":70,"@type":62},"ADC values were significantly different between mucinous and tubular adenocarcinomas, and also between Tis–T1–T2 and T3–T4 stages. These differences were statistically significant, with reported P values of less than 0.01 and 0.02, respectively.","https://schema.org",{"og:url":32,"og:type":73,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":75,"canonical":32},"index,follow",{"doc_id":77,"site_id":7},379861,1790237791,{"code":4,"msg":80,"data":81},"success",[82,86,90,94,99,104,109,113,118,121,125],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":83,"show_sort_weight":84,"slug":85},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":87,"show_sort_weight":88,"slug":89},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":91,"show_sort_weight":92,"slug":93},"Exam",70,"exam",{"id":95,"doc_module":4,"doc_module_name":25,"category_name":96,"show_sort_weight":97,"slug":98},5,"Comic",60,"comic",{"id":100,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},6,"Technology",50,"technology",{"id":105,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},7,"Healthcare",40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":111,"slug":112},8,30,"research-report",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},9,"Religion & Spirituality",20,"religion-spirituality",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":116,"slug":120},"World Cup","world-cup",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":123,"show_sort_weight":122,"slug":124},10,"Lifestyle","lifestyle",{"id":126,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":95,"slug":128},19,"General","general",{"code":4,"msg":80,"data":130},{"doc_id":77,"user_id":131,"nickname":42,"user_avatar":132,"doc_module":4,"category_id":110,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":95,"language":138,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":12,"update_tm":78,"read_time":142},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","®  \n Observational Study   \nValue of apparent diffusion coefficient on MRI for prediction of histopathological type in anal fistula cancer  \nShinji Yamamoto, MMSca ,b,*  , Keiji Yonezawaa , Naoki Fukataa , Koji Takeshita, MD, PhDc ,  \nMakoto Kodama, MD, PhDd, Tetsuro Yamana, MD, PhDe, Shigeru Kiryu, MD, PhDf  , Yukinori Okada, MD, PhDb ,g,*   \n\n| Abstract\u003Cbr>The main histopathological types of anal fistula cancers are mucinous adenocarcinoma and tubular adenocarcinoma. The purpose of this study was to investigate the utility of the apparent diffusion coefficient (ADC) value in magnetic resonance imaging (MRI) to determine the histopathological type of an anal fistula cancer, and to investigate the relationship between ADC values and histopathological type (mucinous type or tubular carcinoma), clinical information, and surgical findings. We retrospectively identified 69 patients diagnosed with anal fistula cancer at our hospital from January 2013 to December 2021. Among them, we selected the patients diagnosed using the same 1.5-T MRI machine, underwent surgery, and a pathological sample was obtained during the operation. Finally, these 25 patients were selected for the analysis since they underwent the imaging scan using the same MRI machine. The ADC value was compared between mucinous and tubular adenocarcinomas, and between tumors at the Tis-T1-T2 and T3-T4 stages. Finally, 25 patients were selected. The mean age of the 25 patients included in the analysis was 60.8 ± 13.3 years and all were males. The median ADC of anal fistula cancers was 1.97 × 10–3 mm2/s for mucinous adenocarcinomas and 1.36 × 10–3 mm2/s for tubular adenocarcinomas; this difference was statistically significant (P \u003C .01) . Furthermore, the median ADC was 1.62 × 10–3 mm2/s for tumors in Tis-T1-T2 stages and 2.01 × 10–3 mm2/s for T3-T4 tumors (P = .02) . The ADC value in MR images may predict the histopathological type and depth of anal fistula cancers. Also, the different ADC values between Tis-T1-T2 and T3-T4 tumors could help predict the classification of progression. |\n| --- |\n| Abbreviations: ADC = apparent diffusion coefficient, CD = Crohn disease, DWI = diffusion-weighted imaging, MRI = magnetic resonance imaging, ROC = receiver operating characteristic. |\n| Keywords: anal fistula cancer, apparent diffusion coefficient, histopathological type |\n\n1. Introduction  \nCancer arising from a fistula in the rectal-anal region (anal fistula cancer) is a malignant type of tumor associated with long-term anal fistulas and is reported to account for approximately 2% to 3% of colorectal cancers.[1,2] The World Health Organization states that anal fistula cancers originate from existing anal glands and fistula tracts.[3] The early diagnosis of anal fistula carcinoma is difficult because of the lack of early clinical symptoms due to its occurrence in a complex and intricate anal fistula tract.[4]  \nThe histopathological types of anal fistula cancer are classified as mucinous adenocarcinoma, tubular adenocarcinoma, adenosquamous carcinoma, and squamous cell carcinoma. Ina review of the clinical pathology and treatment results of 42  \ncases of anal fistula cancer at our hospital, the tumors identified were 32 mucinous adenocarcinomas, 8 tubular type adenocarcinomas, 1 adenosquamous carcinoma, and 1 squamous carcinoma.[2] In a review of the histopathology of 75 cases of anal fistula cancer in Crohn disease (CD), 51 were mucinous  \nadenocarcinomas and 17 tubular type adenocarcinomas.[5]  \nAbdominoperineal resection is the first line of treatment for anal fistula cancers.[6] However, this surgery results in permanent colostomy, which significantly reduces the quality of life. In addition, extensive lymph node dissection may cause lymph node edema as a complication, and it is difficult to predict small lymph node metastases from preoperative imaging. Pre-and postoperative chemoradiotherapy are effective in rectal cancer, and the indications for anorectal-sparing surgery ","cbCais3Bd50vnMmz","https://ap.wps.com/l/cbCais3Bd50vnMmz","pdf",697704,"English","# Abstract\n# Introduction\n## Background on anal fistula cancer\n## Treatment context and diagnostic challenges\n# Ethics, funding, and data availability","[{\"question\":\"What is the purpose of measuring ADC on MRI in anal fistula cancer?\",\"answer\":\"To evaluate whether the apparent diffusion coefficient (ADC) on MRI can predict the histopathological type of anal fistula cancer and assess relationships with clinical information and surgical findings.\"},{\"question\":\"How was the study designed and how many patients were analyzed?\",\"answer\":\"This was a retrospective observational study. Of 69 diagnosed patients, 25 met the criteria and were selected for the final analysis using the same 1.5-T MRI machine and obtaining pathological samples at surgery.\"},{\"question\":\"What differences in ADC were reported between tumor types and stages?\",\"answer\":\"ADC values were significantly different between mucinous and tubular adenocarcinomas, and also between Tis–T1–T2 and T3–T4 stages. These differences were statistically significant, with reported P values of less than 0.01 and 0.02, respectively.\"}]","Value of apparent diffusion coefficient on MRI for prediction of histopathological type in anal fistula cancer | PDF",13]