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This cross-sectional study evaluates prophylactic HPV vaccine value for participants with perinatally acquired HIV who received Gardasil quadrivalent vaccination at least five years earlier. At Newlands Clinic, Zimbabwe, vaginal and penile swabs were tested for HPV types, yielding a 69% HPV-positive rate. Findings show vaccine-preventable and non-vaccine type presence, suggest waning against HPV18, and highlight the need for further research on opportunistic non-vaccine HPV types.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/vaccine-and-non-vaccine-hpv-types-presence-in-adolescents-with-vertically-acquired-hiv-five-years-post-gardasil-quadrivalent-vaccination-the-zimgard-cohort/337415/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/vaccine-and-non-vaccine-hpv-types-presence-in-adolescents-with-vertically-acquired-hiv-five-years-post-gardasil-quadrivalent-vaccination-the-zimgard-cohort/337415.png","ImageObject",300,407,{"name":42,"@type":43},"Himbo","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the study evaluating regarding HPV vaccination?","Question",{"text":63,"@type":64},"The study evaluates whether prophylactic HPV vaccines help prevent new HPV infections among adolescents with perinatally acquired HIV who received the quadrivalent HPV vaccine at least five years earlier.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Where and how was the study conducted?",{"text":68,"@type":64},"The cross-sectional study was conducted at Newlands Clinic in Harare, Zimbabwe. Participants received the Gardasil quadrivalent vaccine starting in December 2015, and vaginal and penile swabs were collected and tested for HPV types.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings about HPV types after vaccination?",{"text":72,"@type":64},"Among analyzed participants, the HPV-positive rate was 69%. Vaccine-preventable low-risk types (HPV6/11) and other types were detected, and the results suggested waning immunity to HPV18 along with reduced cross-protection against HPV45.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337415,1790292016,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":112},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","viruses   \nArticle  \nVaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort  \nAlltalents T. Murahwa 1,2,*, Tinashe Mudzviti 3,4, Racheal S. Dube Mandishora 5,6, Takudzwa Chatindo 3, Peace Chanetsa 3, Margaret Pascoe 3, Tinei Shamu 3,7,8, Wisdom Basera 9, Ruedi Luethy 3 and Anna-Lise Williamson 1,10  \nCitation: Murahwa, A.T.; Mudzviti, T.; Mandishora, R.S.D.; Chatindo, T.; Chanetsa, P.; Pascoe, M.; Shamu, T.; Basera, W.; Luethy, R.; Williamson, A.-L. Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort.  \nViruses 2024, 16, 162. [https://](https://)[ ](https://)[doi.org/10.3390/v16010162](doi.org/10.3390/v16010162)  \nAcademic Editor: Joe S. Mymryk  \nReceived: 13 December 2023  \nRevised: 26 December 2023  \nAccepted: 17 January 2024  \nPublished: 22 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa; [anna-lise.williamson@uct.ac.za](anna-lise.williamson@uct.ac.za)  \n[2](2 Wellcome Centre for Infectious Diseases Research in Africa)[ Wellcome Centre for Infectious Diseases Research in Africa](2 Wellcome Centre for Infectious Diseases Research in Africa) ([CIDRI-Africa](CIDRI-Africa)), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa  \n3 Newlands Clinic, Harare P.O. Box A178, Zimbabwe; [takudzwac@newlandsclinic.org.zw](takudzwac@newlandsclinic.org.zw) (T.C.); [peacec@newlandsclinic.org.zw](peacec@newlandsclinic.org.zw) (P.C.); [margaretp@newlandsclinic.org.zw](margaretp@newlandsclinic.org.zw) (M.P.); [tineis@newlandsclinic.org.zw](tineis@newlandsclinic.org.zw) (T.S.); [ruedi.luethy@rl-foundation.ch](ruedi.luethy@rl-foundation.ch) (R.L.)  \n4 Department of Pharmacy and Pharmaceutical Sciences, University of Zimbabwe, Harare P.O. Box AI78, Zimbabwe  \n5 Medical Microbiology Unit, Department of Laboratory Diagnostic and Investigative Sciences, University of Zimbabwe, Harare P.O. Box AI78, Zimbabwe; [racheal.mandishora@moffitt.org](racheal.mandishora@moffitt.org)  \n6 Center for Immunization and Infection Research in Cancer, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, 33612 FL, USA  \n7 Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland  \n8 Graduate School of Health Sciences, University of Bern, 3012 Bern, Switzerland  \n9 Burden of Disease Research Unit, South African Medical Research Council, Cape Town 7925, South Africa; [wisdom.basera@mrc.ac.za](wisdom.basera@mrc.ac.za)  \n10 SAMRC Gynaecological Cancer Research Centre, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa  \n* Correspondence: [alltalents.murahwa@uct.ac.za](alltalents.murahwa@uct.ac.za)  \nAbstract: Background: Human papillomavirus (HPV) vaccination programs are a key intervention in protecting individuals against HPV-related disease. HIV1-infected individuals are at increased risk of HPV-associated cancers. This study was conducted to evaluate the potential role of prophylactic HPV vaccines in preventing new HPV infections among participants with perinatally acquired HIV who received the quadrivalent HPV vaccine at least five years before this study. Methods: This cross-sectional study was conducted at Newlands Clinic, Harare, Zimbabwe. The clinic provided the Gardasil quadrivalent HPV vaccine (4vHPV) to 624 adolescents living with HIV starting in December 2015. Vaginal and ","cbCairuiugwLbxP5","https://ap.wps.com/l/cbCairuiugwLbxP5","pdf",1972335,12,"English","# Abstract\n# Introduction\n## HPV-related cancer risk\n# Methods\n## Study design and setting\n## Vaccination and sample collection\n# Results\n## HPV positivity and type distribution\n## Vaccine-preventable and non-vaccine types\n# Conclusion","[{\"question\":\"What is the study evaluating regarding HPV vaccination?\",\"answer\":\"The study evaluates whether prophylactic HPV vaccines help prevent new HPV infections among adolescents with perinatally acquired HIV who received the quadrivalent HPV vaccine at least five years earlier.\"},{\"question\":\"Where and how was the study conducted?\",\"answer\":\"The cross-sectional study was conducted at Newlands Clinic in Harare, Zimbabwe. Participants received the Gardasil quadrivalent vaccine starting in December 2015, and vaginal and penile swabs were collected and tested for HPV types.\"},{\"question\":\"What were the main findings about HPV types after vaccination?\",\"answer\":\"Among analyzed participants, the HPV-positive rate was 69%. Vaccine-preventable low-risk types (HPV6/11) and other types were detected, and the results suggested waning immunity to HPV18 along with reduced cross-protection against HPV45.\"}]","Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination - The ZIMGARD Cohort | PDF",1790019041]