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It explains that the listed examples are illustrative and that questions may address additional diseases or symptoms not explicitly listed. The program applies ongoing review and modification of examination content as medical practice guidelines evolve. It also highlights competency emphasis areas such as geriatric medicine, nutrition, and prescription drug use, plus underserved health care needs for returning military personnel, veterans, and families, and for populations requiring health and gender-affirming care, including patients with disabilities.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":20,"@type":76,"position":81},"https://docshare.wps.com/document/exam/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/usmle-content-outline-overview-and-content-organization/389888/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/usmle-content-outline-overview-and-content-organization/389888.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-25",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does the USMLE Content Outline work across different Steps?","Question",{"text":113,"@type":114},"The outline provides a common organization of content across all USMLE examinations, while each Step emphasizes certain parts rather than including questions on every topic.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Are the examples listed in the outline the full set of covered topics?",{"text":118,"@type":114},"No. The examples are illustrative, and USMLE questions may include diseases or symptoms not included in the outline.",{"name":120,"@type":111,"acceptedAnswer":121},"How is USMLE examination content updated over time?",{"text":122,"@type":114},"USMLE continually reviews its examinations to keep content relevant, and modifies it as practice guidelines evolve or new emphases are introduced through ongoing peer-review processes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},389888,1790624543,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","USMLE® Content Outline  \nA Joint Program of the Federation of State Medical Boards of the United  \nStates and NBME®  \nUSMLE Content Outline  \nThe USMLE Content outline provides a common organization of content across all USMLE examinations. Each Step exam will emphasize certain parts of the outline, and no single examination will include questions on all topics in the outline. The examples listed within the outline are just examples. Questions may include diseases, symptoms, etc. , that are not included in the outline. The USMLE program continually reviews its examinations to ensure their content is relevant to the practice of medicine. As practice guidelines evolve or are introduced, the content on USMLE is reviewed and modified as needed. At times, there is a change in emphasis on new content development that arises from our ongoing peer-review processes. For example, there has been an emphasis on new content developed assessing competencies related to geriatric medicine, nutrition, and prescription drug use. USMLE has also focused recent efforts on the often unrecognized health care needs of:  \n• recently returning military personnel and veterans and the families of deployed military personnel  \n• populations requiring health and gender-affirming care (eg, nonbinary and transgender patients)  \n• patients with disabilities  \nAlthough many of the medical issues related to the health care of these special populations are not unique, certain medical illnesses or conditions are either more prevalent, have a different presentation, or are managed differently. Knowledge of foundational science and clinical science in these content areas will be assessed on the USMLE Step 1, Step 2 CK, and Step 3 examinations.  \nUSMLE Physician Tasks/Competencies provides an outline of the tasks and competencies assessed throughout the sequence of USMLE examinations. Please refer to both outlines when preparing for the examinations.  \nExaminees should refer to the test specifications for each examination for more information about which parts of the outline will be emphasized in the examination for which they are preparing. See the USMLE website ([www.usmle.org](www.usmle.org)) for more detail.  \nTable of Contents  \n\n| Human Development Immune System\u003Cbr>Blood & Lymphoreticular System Behavioral Health\u003Cbr>Nervous System & Special Senses Skin & Subcutaneous Tissue Musculoskeletal System Cardiovascular System Respiratory System Gastrointestinal System\u003Cbr>Renal & Urinary System\u003Cbr>Pregnancy, Childbirth, & the Puerperium\u003Cbr>Female and Transgender Reproductive System & Breast Male and Transgender Reproductive System Endocrine System\u003Cbr>Multisystem Processes & Disorders\u003Cbr>Biostatistics, Epidemiology/Population Health, & Interpretation of the Medical Literature\u003Cbr>Social Sciences | 3\u003Cbr>4\u003Cbr>5\u003Cbr>7\u003Cbr>9\u003Cbr>13\u003Cbr>15\u003Cbr>17\u003Cbr>19\u003Cbr>21\u003Cbr>24\u003Cbr>26\u003Cbr>28\u003Cbr>30\u003Cbr>31\u003Cbr>33\u003Cbr>36\u003Cbr>39 |\n| --- | --- |\n\nCopyright © 2026 by the Federation of State Medical Boards of the United States, Inc. (FSMB), and NBME.  \nAll rights reserved. The United States Medical Licensing Examination® (USMLE® ) is a joint program of the FSMB and NBME.  \nHuman Development  \nNormal age-related findings and care of the well patient  \n• Infancy and childhood (0–12 years)  \no Normal physical changes: linear growth, variations in linear growth, including constitutional delay; weight; head circumference; micturition, defecation, primary incontinence/bedwetting; normal physical examination; screening; sleep; teething syndrome  \no Developmental stages: motor; speech; cognitive; psychosocial; anticipatory guidance  \no Lifestyle and routine preventive health care: nutrition; exercise (eg, benefits of exercise); preventive/travel medicine; risk factors and prevention (eg, guns, swimming, motor vehicles, car seats); routine vaccinations; adaptive behavioral responses to stress and illness (eg, coping mechanisms); patient adherence  \n• Adolescence (13–17 years)  \no Normal physical changes: linear grow","cbCaifSdeEtUuSva","https://ap.wps.com/l/cbCaifSdeEtUuSva","pdf",736834,42,"English","# Human Development\n## Normal age-related findings and care of the well patient\n# Immune System\n## Disorders associated with immunodeficiency","[{\"question\":\"How does the USMLE Content Outline work across different Steps?\",\"answer\":\"The outline provides a common organization of content across all USMLE examinations, while each Step emphasizes certain parts rather than including questions on every topic.\"},{\"question\":\"Are the examples listed in the outline the full set of covered topics?\",\"answer\":\"No. The examples are illustrative, and USMLE questions may include diseases or symptoms not included in the outline.\"},{\"question\":\"How is USMLE examination content updated over time?\",\"answer\":\"USMLE continually reviews its examinations to keep content relevant, and modifies it as practice guidelines evolve or new emphases are introduced through ongoing peer-review processes.\"}]","USMLE Content Outline - Overview and Content Organization | PDF",1790328231,106]