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The outline clarifies that examples are illustrative and questions may test relevant diseases or symptoms not explicitly listed. It also describes an ongoing peer-review process that updates content as medical practice guidelines evolve, including changing emphasis such as geriatric competence, medication use and abuse, and health care needs of returning servicemembers and families of deployed personnel.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":20,"@type":76,"position":81},"https://docshare.wps.com/document/exam/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/usmle-content-outline-exam-content-organization/390609/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/usmle-content-outline-exam-content-organization/390609.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-25",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Does every USMLE exam include questions on all topics in the outline?","Question",{"text":112,"@type":113},"No. Each Step exam emphasizes certain parts of the outline, and no single examination includes questions on all topics listed.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Are the examples in the outline comprehensive?",{"text":117,"@type":113},"No. Examples are for illustration only, and questions may involve diseases or symptoms not included in the outline.",{"name":119,"@type":110,"acceptedAnswer":120},"How is the USMLE outline kept up to date?",{"text":121,"@type":113},"USMLE continually reviews its examinations through ongoing peer-review processes and updates content as practice guidelines evolve, including changes in emphasis on new content development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},390609,1791332781,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","USMLE®  \nContent Outline  \nA Joint Program of the Federation of State Medical Boards  \nof the United States, Inc., and the National Board of Medical Examiners®  \nThis outline provides a common organization of content across all USMLE examinations. Each Step exam will emphasize certain parts of the outline, and no single examination will include questions on all topics in the outline. The examples listed within the outline are just examples. Questions may include diseases, symptoms, etc., that are not included in the outline. The USMLE program continually reviews its examinations to ensure their content is relevant to the practice of medicine. As practice guidelines evolve or are introduced, the content on USMLE is reviewed and modified as needed. At times, there is a change in emphasis on new content development that arises from our ongoing peer-review processes. For example, there has been an emphasis on new content developed assessing competencies related to geriatric medicine, and prescription drug use and abuse. USMLE has also focused recent efforts on the often unrecognized health care needs of recently returning servicemen and servicewomen (eg, traumatic brain injury and post-traumatic stress disorder), and the families of deployed servicemen and servicewomen. While many of the medical issues related to the health care of these special populations are not unique, certain medical illnesses or conditions are either more prevalent, have a different presentation, or are managed differently. Knowledge of foundational science and clinical science in these content areas will be assessed on the USMLE Step 1, Step 2 CK, and Step 3 examinations.  \nExaminees should refer to the test specifications for each examination for more information about which parts of the outline will be emphasized in the examination for which they are preparing. See the USMLE website ([www.usmle.org](www.usmle.org)) for more detail.  \nCopyright © 2017 by the Federation of State Medical Boards of the United States, Inc. (FSMB) and the National Board of Medical Examiners® (NBME®). All rights reserved. Printed in the United States of America. The United States Medical Licensing Examination® (USMLE®) is a joint program of the FSMB and the NBME.  \nTable of Contents  \nGeneral Principles of Foundational Science 2  \nImmune System 4  \nBlood & Lymphoreticular System 5  \nBehavioral Health 7  \nNervous System & Special Senses 8  \nSkin & Subcutaneous Tissue 11  \nMusculoskeletal System 12  \nCardiovascular System 13  \nRespiratory System 15  \nGastrointestinal System 16  \nRenal & Urinary System 18  \nPregnancy, Childbirth, & the Puerperium 20  \nFemale Reproductive System & Breast 21  \nMale Reproductive System 22  \nEndocrine System 23  \nMultisystem Processes & Disorders 24  \nBiostatistics, Epidemiology/Population Health, &  \nInterpretation of the Medical Literature 27  \nSocial Sciences 29  \nGeneral Principles of Foundational Science  \nBiochemistry and molecular biology  \nGene expression: DNA structure, replication, exchange, and epigenetics (eg, imprinting, Xactivation, DNA methylation)  \nGene expression: transcription  \nGene expression: translation, post-translational processing, modifications, and disposition of proteins (degradation), including protein/glycoprotein synthesis, intra-extracellular sorting, and processes/functions related to Golgi complex and rough endoplasmic reticulum  \nStructure and function of proteins and enzymes (eg, enzyme kinetics and  \nstructural/regulatory proteins)  \nEnergy metabolism (eg, ATP generation, transport chain)  \nBiology of cells  \nAdaptive cell responses and cellular homeostasis (eg, hypertrophy)  \nMechanisms of injury and necrosis, including pathologic processes (eg, liquefactive necrosis, free radical formation)  \nApoptosis  \nCell cycle and cell cycle regulation (eg, mitosis)  \nMechanisms of dysregulation  \ncell biology of cancer (eg, role of p53, proto-oncogenes)  \ngeneral principles of invasion and metastasis, including cancer stagi","cbCaibtyNca00s3e","https://ap.wps.com/l/cbCaibtyNca00s3e","pdf",1437862,34,"English","# General Principles of Foundational Science\n# Immune System\n# Blood & Lymphoreticular System\n# Behavioral Health\n# Nervous System & Special Senses\n# Skin & Subcutaneous Tissue\n# Musculoskeletal System\n# Cardiovascular System\n# Respiratory System\n# Gastrointestinal System\n# Renal & Urinary System\n# Pregnancy, Childbirth, & the Puerperium\n# Female Reproductive System & Breast\n# Male Reproductive System\n# Endocrine System\n# Multisystem Processes & Disorders\n# Biostatistics, Epidemiology/Population Health, & Interpretation of the Medical Literature\n# Social Sciences","[{\"question\":\"Does every USMLE exam include questions on all topics in the outline?\",\"answer\":\"No. Each Step exam emphasizes certain parts of the outline, and no single examination includes questions on all topics listed.\"},{\"question\":\"Are the examples in the outline comprehensive?\",\"answer\":\"No. Examples are for illustration only, and questions may involve diseases or symptoms not included in the outline.\"},{\"question\":\"How is the USMLE outline kept up to date?\",\"answer\":\"USMLE continually reviews its examinations through ongoing peer-review processes and updates content as practice guidelines evolve, including changes in emphasis on new content development.\"}]","USMLE Content Outline - Exam Content Organization | PDF",1790336846,86]