[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-461541-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-461541-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","use-of-polylactic-acid-dermal-matrix-for-the-management-of-wounds-with-exposed-avascular-structures-case-report","Use of Polylactic Acid Dermal Matrix for the Management of Wounds with Exposed Avascular Structures - Case Report","","Wounds with an avascular component present a major clinical challenge because impaired blood flow limits revascularization and regenerative tissue formation. This case series reports outcomes in five patients with complex wounds showing exposure of avascular structures from different etiologies, treated successfully with poly-lactic acid (PLA) dermal matrices. Wound bed preparation combined debridement with PLA application followed by protective multilayer dressings. Weekly evaluations continued until complete closure, with granulation and reepithelialization observed in all cases.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/use-of-polylactic-acid-dermal-matrix-for-the-management-of-wounds-with-exposed-avascular-structures-case-report/461541/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/use-of-polylactic-acid-dermal-matrix-for-the-management-of-wounds-with-exposed-avascular-structures-case-report/461541.png","ImageObject",300,407,{"name":42,"@type":43},"awa","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-06","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What problem do avascular wounds present during healing?","Question",{"text":63,"@type":64},"Avascular wounds involve exposed structures without adequate blood flow, which hinders revascularization and the formation of regenerative tissue necessary for normal healing progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were PLA dermal matrices applied in these cases?",{"text":68,"@type":64},"After debridement, PLA was applied to the wound, then covered with additional layers such as a nonadherent dressing, absorbent dressing, and compression bandage as needed.",{"name":70,"@type":61,"acceptedAnswer":71},"What outcomes were reported after PLA matrix treatment?",{"text":72,"@type":64},"All cases achieved successful closure with PLA supporting granulation tissue formation and reepithelialization; one patient required skin grafts for complete healing. No local infections were reported before or after PLA application.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},461541,1790793986,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},3985747858093,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Case Report  \nUse of Polylactic Acid Dermal Matrix for the Management of Wounds with Exposed Avascular Structures  \nMario Aurelio Martínez-Jiménez 1, Ana Lorena Novoa-Moreno 1, *, Victor Manuel Loza-González 2, Rafael Pérez-Medina-Carballo 3 and Patricia Aurea Cervantes-Báez 1  \nAcademic Editor: Hajime Matsumura  \nReceived: 11 November 2025  \nRevised: 15 December 2025  \nAccepted: 15 December 2025  \nPublished: 19 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Burn Unit, Regional High-Specialty Hospital “Dr. Ignacio Morones Prieto”, San Luis Potosí 78290, Mexico; [paty.cervantesb@hotmail.com](paty.cervantesb@hotmail.com) (P.A.C.-B.)  \n2 Institutional Doctorate in Engineering and Science of Materials, Autonomous University of San Luis Potosí, San Luis Potosí 78290, Mexico  \n3 Integrated Program in Neuroscience, Faculty of Science, McGill University, Montreal, QC H3A 0G4, Canada; rafael.perezmedinacarballo@mail.mcgill.ca  \n* [Correspondence: novoaalore@gmail.com](Correspondence: novoaalore@gmail.com)  \nAbstract  \nBackground: Wounds with an avascular component represent a significant challenge in medical care due to impaired blood flow. Synthetic matrices, such as poly-lactic acid (PLA), have demonstrated promising results in promoting wound healing in complex wounds, including those with restricted blood supply, such as diabetic foot and venous leg ulcers. Objective: This case series presents the outcomes of five patients with wounds containing exposure of avascular components, of various etiologies successfully treated with PLA matrices. Case description: Five patients presented complex wounds involving exposure of bone, tendon, fascia, or osteosynthetic material. Wound bed preparation included debridement followed by PLA application covered with additional layers (nonadherent dressing, absorbent dressing, and compression bandage) as needed. Weekly assessments were conducted until full wound closure was achieved. Results: All cases showed successful outcomes, with PLA promoting granulation tissue formation and reepithelialization, contributing to wound closure. One patient required skin grafts for complete healing. No local infections were reported before or after PLA application. Conclusions: PLA matrices are a practical and effective option for managing complex wounds, promoting tissue regeneration and optimizing wound bed quality for skin grafts or flaps. While these findings are promising, further studies are needed to confirm the broader applicability and efficacy of PLA in the management of wounds containing exposure of avascular structures.  \nKeywords: avascular; wounds; polylactic acid; synthetic biomaterials; tissue regeneration  \n1. Introduction  \nWounds with avascular components, such as exposed bone, joint surfaces, tendons, and orthopedic hardware, pose significant challenges in wound care due to the lack of blood flow to these structures. This absence hinders revascularization and the formation of regenerative tissue, which is crucial for advancing smoothly along the stages of healing. Advancing from a starting stage of inflammation to a proliferation stage where granulation tissue starts to develop, the neoformation of blood vessels is determining [1] .  \nHistorically, the gold standard for treating such complex soft tissue defects has been the transfer of vascularized tissue through microsurgical procedures or regional muscle,  \nskin, or fascia transposition [2] . However, recent technologies such as negative wound pressure therapy and cellular, acellular and matrix-like products (CAMPs) have allowed the closure of these defects through less invasive procedures via a combination of wound bed temporization and skin grafting [3,4] . A systematic review performed by Iorio et al. analyzed 13 primary studies with a total of 432 patients and conc","cbCair5kdt4UB95e","https://ap.wps.com/l/cbCair5kdt4UB95e","pdf",2758231,"English","# Abstract\n# Introduction\n# Case Description","[{\"question\":\"What problem do avascular wounds present during healing?\",\"answer\":\"Avascular wounds involve exposed structures without adequate blood flow, which hinders revascularization and the formation of regenerative tissue necessary for normal healing progression.\"},{\"question\":\"How were PLA dermal matrices applied in these cases?\",\"answer\":\"After debridement, PLA was applied to the wound, then covered with additional layers such as a nonadherent dressing, absorbent dressing, and compression bandage as needed.\"},{\"question\":\"What outcomes were reported after PLA matrix treatment?\",\"answer\":\"All cases achieved successful closure with PLA supporting granulation tissue formation and reepithelialization; one patient required skin grafts for complete healing. No local infections were reported before or after PLA application.\"}]","Use of Polylactic Acid Dermal Matrix for the Management of Wounds with Exposed Avascular Structures - Case Report | PDF",1790761836,23]