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This retrospective cohort study analyzed Medicare (2013–2018) and Optum Clinformatics (2013–2024) to compare quetiapine, risperidone, and olanzapine initiated within 30 days after discharge. Using propensity score overlap weighting, it assessed mortality and rehospitalization outcomes, with on-treatment effects estimated by Poisson regression and pooled across databases via fixed-effect meta-analysis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/use-of-atypical-antipsychotics-for-post-hospitalization-delirium-and-associated-clinical-outcomes-in-older-adults/424711/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/use-of-atypical-antipsychotics-for-post-hospitalization-delirium-and-associated-clinical-outcomes-in-older-adults/424711.png","ImageObject",300,407,{"name":92,"@type":93},"awa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which atypical antipsychotics were compared in this study?","Question",{"text":112,"@type":113},"The study compared quetiapine, risperidone, and olanzapine among older adults after hospital discharge.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were study participants selected?",{"text":117,"@type":113},"Participants were aged 65 or older without psychiatric disorders who newly filled one of the three medications within 30 days of discharge.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings about mortality and rehospitalization risks?",{"text":121,"@type":113},"Olanzapine was associated with a higher risk of death compared with risperidone, and it also showed higher rehospitalization rates, including increased risk of delirium as a rehospitalization reason versus quetiapine and risperidone.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},424711,1791034624,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},3985747858093,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","484 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1652  \nUSE OF ATYPICAL ANTIPSYCHOTICS FOR  \nPOST-HOSPITALIZATION DELIRIUM AND  \nASSOCIATED CLINICAL OUTCOMES IN  \nOLDER ADULTS  \nChun-Ting Yang1, James Wilkins2, Kevin Pritchard1, Xiaojuan Liu1, Dae Hyun Kim3, and Joshua Lin1, 1. Brigham and Women’s Hospital, Boston, Massachusetts, United States, 2. McLean Hospital, Belmont, Massachusetts, United States, 3. Hebrew SeniorLife, Boston, Massachusetts, United States  \nAtypical antipsychotic medications (APMs) are commonly prescribed to manage delirium symptoms among hospitalized older adults, but their comparative safety beyond hospital discharge remains unknown. This retrospective cohort study utilized Medicare 2013-2018 and Optum Clinformatics® 2013-2024 to examine the risks of clinical outcomes between quetiapine, risperidone, and olanzapine use among older adults following hospitalization. We included patients aged≥65 years without psychiatric disorders who newly filled quetiapine, risperidone, or olanzapine within 30 days of hospital discharge. The index date was the first dispensing date of the APM. Propensity score overlap weighting was employed to balance baseline covariates.  \nOutcomes included all-cause mortality, all-cause rehospitalization, and specific rehospitalization causes. The on-treatment effects were measured using Poisson regression model. Analyses were conducted in the two databases separately and the effect estimates were pooled by fixed-effect meta-analysis. A total of 32,209, 9,732, and 6,363 quetiapine, risperidone, and olanzapine users were identified. The mortality rate (per 1000 person-years) was 478.1 for quetiapine (reference), 544.3 for risperidone (rate ratio [95% CI]: 1.11 [0.96-1.29]), and 726.2 for olanzapine (1.49 [1.30-1.71]) . The rehospitalization rate was 1,408.6 for quetiapine (reference), 1,540.6 for risperidone (1.07 [0.97-1.17]), and 1,703.2 for olanzapine (1.16 [1.06-1.29]) .  \nOlanzapine also showed a significantly higher risk of death (1.34 [1.17-1.53]) compared to risperidone. Among rehospitalization reasons, olanzapine was associated with an increased risk of delirium compared to quetiapine (1.34 [1.12-1.60]) andrisperidone (1.20 [1.01-1.42]) . Our findings suggest that olanzapine increased the risks of adverse outcomes compared torisperidone and quetiapine among older adults prescribed with APMs after hospital discharge.","cbCainxXSEfiofs1","https://ap.wps.com/l/cbCainxXSEfiofs1","pdf",462987,"English","# Abstract\n## Study design and population\n## Outcomes and analysis methods\n## Key results and clinical implications","[{\"question\":\"Which atypical antipsychotics were compared in this study?\",\"answer\":\"The study compared quetiapine, risperidone, and olanzapine among older adults after hospital discharge.\"},{\"question\":\"How were study participants selected?\",\"answer\":\"Participants were aged 65 or older without psychiatric disorders who newly filled one of the three medications within 30 days of discharge.\"},{\"question\":\"What were the main findings about mortality and rehospitalization risks?\",\"answer\":\"Olanzapine was associated with a higher risk of death compared with risperidone, and it also showed higher rehospitalization rates, including increased risk of delirium as a rehospitalization reason versus quetiapine and risperidone.\"}]","Use of Atypical Antipsychotics for Post-Hospitalization Delirium and Associated Clinical Outcomes in Older Adults | PDF",1790635134]