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Ninety-four adult patients with hypertensive intracerebral hemorrhage with ventricular extension or primary IVH were compared between “EVD combined with fibrinolysis” and “EVD only.” IVH severity was quantified using the mGRAEB score by serial non-contrast CT, with functional outcome and shunt dependency as secondary outcomes.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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retrospective analysis of hemorrhage volume reduction and clinical outcomes  \nChi-Ruei Lia, Meng-Yin Yanga,b,c, Wen-Yu Chenga,d,e, Huan-Chin Tsengf,g, Yi-Ying Linf,g,  \nYu-Hao Liuf,g, Chiung-Chyi Shena,e,h, Chun-Ming Yena,i,*  \naDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; bOncology Neurosurgery Division, Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; cCollege of Nursing, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC; dInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan, ROC; eDepartment of Physical Therapy, Hung Kuang University, Taichung, Taiwan, ROC; fSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; gDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; hBasic Medical Education, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC; iSchool of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC  \nAbstract  \nBackground: Intraventricular hemorrhage (IVH) is a type of ventricular bleeding that results in significant morbidity and mortality. Multiple studies have investigated the use of urokinase in IVH treatment. The use of urokinase may lead to higher rates of hematoma resolution and lower mortality rates. However, further studies are required to determine efficacy of urokinase administration. This study examined the association between urokinase use, IVH volume reduction, and clinical outcomes.  \nMethods: In total, 94 adult patients with hypertensive intracerebral hemorrhage with ventricular extension or primary IVH were enrolled between 2015 and 2021. Participants were categorized into two groups: “EVD combined with fibrinolysis” and “EVD only.” The primary objective was to assess the reduction of IVH severity. Additionally, the study evaluated the functional outcomesand shunt dependency rate as secondary outcomes. Non-contrast computed tomography scans were obtained to measure the severity of IVH using the mGRAEB score. The main outcomes were the association among urokinase administration, reduced IVH severity, and functional outcomes.  \nResults: There were no significant differences in the reduction rate of mGRAEB scores within a 7-day period (−50 .0 [−64 .4 to −32 .5]% vs −44.2 [−59 .3 to −7 .9]%; p = 0 .489) . In addition, investigation of the third and fourth ventricles showed similar findings between the two groups. Urokinase treatment was not associated with significant differences in the modified Rankin Scale (5 .0 (4 .0–5.0) vs. 4.5 (4 .0-5.0), p = 0.674) or shunt dependency rate (33 .3% vs 39.3%, p = 0.58) .  \nConclusion: This study found that intraventricular urokinase use in patients with IVH was not associated with reduced IVH severity. In addition, urokinase use was not associated with better functional outcomes or minor shunt dependency rates.  \nKeywords: Intracerebral hemorrhage; Intraventricular hemorrhage; mGRAEB score; Shunt dependency; Urokinase  \n1. INTRODUCTION  \nIntraventricular hemorrhage (IVH) is a type of bleeding that occurs within the ventricular system of the brain, which comprises four interconnected cavities filled with cerebrospinal  \n*Address correspondence. Dr. Chun-Ming Yen, Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung 407, Taiwan, ROC. E-mail address: chunmingyen@ [gmail.com](gmail.com) (C.-M. Yen).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 930-934.  \nReceived May 11, 2023; accepted July 19, 2023.  \ndoi: 10. 1097/JCMA.0000000000000973.  \nCopyright © 2","cbCaicwboMxek7lv","https://ap.wps.com/l/cbCaicwboMxek7lv","pdf",731436,"English","# Abstract\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What patient groups were compared in the retrospective study?\",\"answer\":\"Ninety-four adults with hypertensive intracerebral hemorrhage with ventricular extension or primary IVH were split into “EVD combined with fibrinolysis” versus “EVD only.”\"},{\"question\":\"How was IVH severity measured?\",\"answer\":\"Non-contrast computed tomography was used to quantify IVH severity using the mGRAEB score.\"},{\"question\":\"Did urokinase reduce IVH severity or improve clinical outcomes?\",\"answer\":\"Urokinase use was not associated with reduced IVH severity over 7 days and was not linked to better modified Rankin Scale outcomes or lower shunt dependency rates.\"}]","Urokinase administration for intraventricular hemorrhage in adults: A retrospective analysis of hemorrhage volume reduction and clinical outcomes | PDF",1790677506,13]