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This study evaluates ureteroscopy as a treatment strategy by combining a retrospective institutional series from Singapore General Hospital (2015–2023) with a systematic review of primary studies through August 13, 2023. Outcomes include stone-free status and complication profiles, comparing results with non-transplant ureteroscopy populations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ureteroscopy-for-renal-allograft-lithiasis-institutional-experience-and-global-insights-from-a-systematic-review/456686/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ureteroscopy-for-renal-allograft-lithiasis-institutional-experience-and-global-insights-from-a-systematic-review/456686.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address for kidney transplant patients?","Question",{"text":112,"@type":113},"The study addresses renal allograft lithiasis, a rare but potentially serious post-transplant complication that can lead to sepsis, obstruction, and potential graft loss if not treated promptly.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the evidence sources collected?",{"text":117,"@type":113},"It includes a retrospective review of renal allograft lithiasis cases treated with ureteroscopy at Singapore General Hospital from January 2015 to December 2023, plus a systematic literature review using five databases up to August 13, 2023.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main effectiveness and safety outcomes?",{"text":121,"@type":113},"In the institutional series, the stone-free rate was 71.4%, and the systematic review showed an overall stone-free rate of 82.3%. Thirteen complications (9.0%) were reported in the systematic review, and no graft loss was reported.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},456686,1790793996,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Ureteroscopy for renal allograft lithiasis: institutional experience and global insights from a systematic review  \nJun Heng Lim 1\\#, Xinyan Yang 1\\#, Tsung Wen Chong 1, Edwin Jonathan Aslim 1, Valerie H. L. Gan 1,2, Lay Guat Ng1, Kazumi Taguchi3, Yadong Lu1^  \n1Department of Urology, Singapore General Hospital, Singapore, Singapore; 2SingHealth Duke-NUS Transplant Centre, Singapore, Singapore; 3Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan  \nContributions: (I) Conception and design: JH Lim, X Yang, TW Chong, Y Lu; (II) Administrative support: EJ Aslim, VHL Gan, LG Ng; (III) Provision of study materials or patients: TW Chong, EJ Aslim, LG Ng, VHL Gan, Y Lu; (IV) Collection and assembly of data: JH Lim, X Yang, VHL Gan; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work.  \nCorrespondence to: Yadong Lu, MD. Department of Urology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.  \n[Email: yadong.lu@yahoo.com](Email: yadong.lu@yahoo.com).  \nBackground: Renal allograft lithiasis (RAL) is a rare but potentially serious complication following kidney transplantation. Traditionally, ureteroscopy (URS) has been considered a second-line treatment for stones \u003C15 mm, typically after failed extracorporeal shock wave lithotripsy (ESWL), due to concerns over challenging ureteral access. This study reviews Singapore General Hospital (SGH)’s experience and  \ncompares outcomes with published literature to evaluate efficacy and safety.  \nMethods: Retrospective review was conducted on RAL cases treated with URS at SGH from January 2015 to December 2023. Data collected included demographics, end-stage renal failure etiology, preoperative biochemistry, stone characteristics, and surgical details. Stone-free status and complications were assessed.  \nAdditionally, a systematic literature review was performed using five databases (PubMed, Embase, Web of Science, SCOPUS, Cochrane Library) from inception up to August 13, 2023. We included all primary studies with no restriction on study design, published in English, including conference abstracts and excluded articles on ex-vivo or pre-transplant URS. Risk of bias assessment was performed using Joanna Briggs  \nInstitute Critical Appraisal Tools.  \nResults: Five URS procedures were performed at SGH for RAL during the study period, yielding a stone-free rate (SFR) of 71.4% . One case involved an encrusted double-J (DJ) stent. The systematic review included 30 studies (10 case reports, 20 case series) totaling 145 URS procedures. The overall SFR was 82.3% . Thirteen complications (9.0%) were reported, including ureteral perforation (n=3), urinary tract infections (n=3), and nephrocutaneous fistula (n=2) . No graft loss was reported. These rates are comparable  \nto those seen in non-transplant URS.  \nConclusions: URS appears to be a safe and effective treatment for RAL, with outcomes comparable to non-transplant populations. Increasing evidence supports URS as a first-line option in select transplant patients. The current evidence is limited by small case numbers, retrospective study designs, and lack of  \nstandardisation in defining and assessing stone-free outcomes.  \nKeywords: Renal allograft lithiasis (RAL); ureteroscopy (URS); kidney transplantation; endourology; stone-free  \nrate (SFR)  \nSubmitted Aug 12, 2025. Accepted for publication Nov 04, 2025. Published online Dec 18, 2025.  \ndoi: 10.21037/tau-2025-574  \nView this article at: [https://dx.doi.org/10.21037/tau-2025-574](https://dx.doi.org/10.21037/tau-2025-574)  \n^ ORCID: 0000-0001-8695-9834.  \n© AME Publishing Company. Transl Androl Urol 2025;14(12):3988-4001 | [https://dx.doi.org/10.21037/tau-2025-574](https://dx.doi.org/10.21037/tau-2025-574)  \nTranslational Andrology and Urology, Vol 14, No 12 December 2025 3989  \nIntroduction  \nRe","cbCaig5QPpo2GXVo","https://ap.wps.com/l/cbCaig5QPpo2GXVo","pdf",389794,14,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Highlight box","[{\"question\":\"What problem does the study address for kidney transplant patients?\",\"answer\":\"The study addresses renal allograft lithiasis, a rare but potentially serious post-transplant complication that can lead to sepsis, obstruction, and potential graft loss if not treated promptly.\"},{\"question\":\"How were the evidence sources collected?\",\"answer\":\"It includes a retrospective review of renal allograft lithiasis cases treated with ureteroscopy at Singapore General Hospital from January 2015 to December 2023, plus a systematic literature review using five databases up to August 13, 2023.\"},{\"question\":\"What were the main effectiveness and safety outcomes?\",\"answer\":\"In the institutional series, the stone-free rate was 71.4%, and the systematic review showed an overall stone-free rate of 82.3%. Thirteen complications (9.0%) were reported in the systematic review, and no graft loss was reported.\"}]","Ureteroscopy for renal allograft lithiasis - institutional experience and global insights from a systematic review | PDF",1790746720,35]