[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374534-105":59,"doc-detail-374534-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","updates-and-controversies-for-desmoids-in-familial-adenomatous-polyposis-review","Updates and controversies for desmoids in familial adenomatous polyposis - review","","Desmoids are rare non-cancerous fibrous growths in familial adenomatous polyposis (FAP) that show highly variable behavior, from indolent progression or even regression to locally aggressive, progressive tumors causing substantial morbidity or mortality. About 10–15% of FAP patients develop desmoid disease, commonly after abdominal surgery and often involving the abdomen, abdominal wall, or limbs. Management is difficult and benefits from multidisciplinary care at specialized centers. Emerging therapies include tyrosine kinase inhibitors, γ-secretase inhibitors, and ablation techniques alongside NSAIDs, anti-hormonal therapy, chemotherapy, radiotherapy, and surgery. Decisions about prophylactic colectomy must weigh surgical desmoidogenic risk, especially in high-risk patients. ",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/updates-and-controversies-for-desmoids-in-familial-adenomatous-polyposis-review/374534/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/updates-and-controversies-for-desmoids-in-familial-adenomatous-polyposis-review/374534.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are desmoids in the context of familial adenomatous polyposis (FAP)?","Question",{"text":113,"@type":114},"Desmoids are rare non-cancerous fibrous growths with variable behavior. In FAP, they commonly involve the abdomen, abdominal wall, or limbs and can range from indolent growth to locally aggressive disease.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is management of desmoid disease in FAP challenging?",{"text":118,"@type":114},"Disease behavior is variable, treatment requires balancing tumor control with risks such as functional impairment and complications, and timing decisions (including post-surgery risk) add complexity. The article emphasizes multidisciplinary care at specialized centers.",{"name":120,"@type":111,"acceptedAnswer":121},"What factors influence the risk of desmoid disease in FAP patients?",{"text":122,"@type":114},"The text highlights that most FAP desmoids occur after abdominal surgery and that risk is higher in certain groups, including high-risk individuals with positive family history, extracolonic manifestations, and carriers of particular genotypes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},374534,1790245844,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Familial Cancer (2025) 24:56  \n[https://doi.org/10.1007/s10689-025-00481-9](https://doi.org/10.1007/s10689-025-00481-9)  \nREVIEW  \nUpdates and controversies for desmoids in familial adenomatous polyposis  \nRami James N. Aoun1 · Matthew F. Kalady1  \nReceived: 16 February 2025 / Accepted: 30 May 2025 / Published online: 20 June 2025 © The Author(s) 2025  \nAbstract  \nDesmoids are rare non-cancerous fibrous growths with variable behavior ranging from slow indolent growth or even regression, to locally aggressive and progressive tumors that can cause significant morbidity or mortality. Approximately 10–15% of patients with familial adenomatous polyposis (FAP) develop desmoid disease, most commonly located in the abdomen, on the abdominal wall, or in limbs. The majority of desmoids in FAP occur after abdominal surgery. Management is quite challenging and employing a multidisciplinary team at a specialized center is important for success. New treatment modalities have emerged, including tyrosine kinase inhibitors, γ-secretase inhibitors, and ablation techniques, complementing the existing repertoire of therapies such as NSAIDs, anti-hormonal therapy, chemotherapy, radiotherapy, and surgical interventions. Surgery remains the treatment of choice for easily resectable abdominal wall desmoids and intra-abdominal desmoids that cause intractable symptoms, or progressive disease despite alternate therapies, or complications from the invasion of nearby organs. When considering prophylactic colectomies in FAP patients, it’s essential to account for the desmoidogenic potential of surgical interventions, especially in high-risk individuals with a positive family history of desmoids, presence of extracolonic manifestations and carriers of certain genotypes. Given the rarity of the disease and the variability in both anatomical presentation and clinical course, desmoids should be managed by a multidisciplinary team capable of coordinating patient specific care and optimizing treatment options.  \nKeywords Desmoids · Familial adenomatous polyposis · Hereditary colorectal cancer · Polyposis  \nIntroduction  \nDesmoid tumors (DT) are rare mesenchymal derived clonal fibroblastic malignancies. They are benign in nature but exert morbidity through mass effect and local invasion of adjacent tissues and structures. Variability in growth, location, and clinical behavior, coupled with high local recurrence ratesand protracted natural history, create a management challenge [1, 2]. As a result, establishing standardized treatment guidelines has been difficult, particularly desmoid disease  \n􀀍 Matthew F. Kalady [matthew.kalady@osumc.edu](matthew.kalady@osumc.edu)  \nRami James N. Aoun  \n[ramijames.aoun@osumc.edu](ramijames.aoun@osumc.edu)  \n1 Division of Colorectal Surgery, Department of Surgery, The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, 410 W 10thAve, Doan Hall 737B, Columbus, OH 43210, USA  \nin the setting of familial adenomatous polyposis (FAP) . Infact, standards of therapy have been in flux and in constant revision over the last few decades as our understanding of the disease has deepened [–] . Management strategies have evolved from an emphasis on aggressive surgical resection to a more multifaceted approach. This includes noninterventional active surveillance as well as medical therapy (including chemotherapy), ablative procedures, surgery, and radiation [1, 4, 5, 7]. Treatments must carefully balance control of disease burden with the risk of functional impairments, complications, and economic burden [8] . This manuscript will provide a brief overview of desmoid disease in FAP with a focus on some of current controversies in management and offer some practical applications.  \nBackground  \nDesmoid tumors have an average annual incidence of 3.2 per million individuals [9] . The disease has a higher predilection in females with a median age of diagnosis of 38 years, and a range of diagnosis between 3 to 67 years","cbCaihCcY7jVssLV","https://ap.wps.com/l/cbCaihCcY7jVssLV","pdf",1465367,"English","# Abstract\n# Introduction\n# Background","[{\"question\":\"What are desmoids in the context of familial adenomatous polyposis (FAP)?\",\"answer\":\"Desmoids are rare non-cancerous fibrous growths with variable behavior. In FAP, they commonly involve the abdomen, abdominal wall, or limbs and can range from indolent growth to locally aggressive disease.\"},{\"question\":\"Why is management of desmoid disease in FAP challenging?\",\"answer\":\"Disease behavior is variable, treatment requires balancing tumor control with risks such as functional impairment and complications, and timing decisions (including post-surgery risk) add complexity. The article emphasizes multidisciplinary care at specialized centers.\"},{\"question\":\"What factors influence the risk of desmoid disease in FAP patients?\",\"answer\":\"The text highlights that most FAP desmoids occur after abdominal surgery and that risk is higher in certain groups, including high-risk individuals with positive family history, extracolonic manifestations, and carriers of particular genotypes.\"}]","Updates and controversies for desmoids in familial adenomatous polyposis - review | PDF",1790201847,25]