[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332857-105":59,"doc-detail-332857-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","updated-findings-on-temporal-variation-in-radiation-effects-on-cancer-mortality-in-an-international-cohort-of-nuclear-workers-inworks-cohort-update","Updated findings on temporal variation in radiation-effects on cancer mortality in an international cohort of nuclear workers (INWORKS) - COHORT UPDATE","","The International Nuclear Workers Study (INWORKS) advances evidence on the dose-response relationship between predominantly low dose, low dose rate occupational exposures to penetrating ionizing radiation and cause-specific mortality. Extending follow-up of 309,932 workers from France (1968–2014), the UK (1955–2012), and the US (1944–2016), the study evaluates whether age at exposure, time since exposure, or attained age individually modify associations between radiation and mortality from all solid cancers, lung cancer, and lymphohematopoietic cancers. Multivariable Poisson regression fits general relative rate models describing modification of the linear excess relative rate per unit organ absorbed dose. Results suggest greater per-dose risk for solid cancer mortality among more recently hired workers, with sensitivity analyses by year of hire performed. Findings were broadly consistent with prior INWORKS pooled and country analyses, showing temporal patterns that differ by cancer type and evidence of persistent radiation-associated excess cancer risk decades after exposure, though statistically significant temporal modification was not generally observed. Stratification by hire period (\u003C1958, 1958+) showed varying temporal patterns without indicating that these differences were driven by changes in distributions of effect modifiers by hire year.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/updated-findings-on-temporal-variation-in-radiation-effects-on-cancer-mortality-in-an-international-cohort-of-nuclear-workers-inworks-cohort-update/332857/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/updated-findings-on-temporal-variation-in-radiation-effects-on-cancer-mortality-in-an-international-cohort-of-nuclear-workers-inworks-cohort-update/332857.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the INWORKS study evaluate in this work?","Question",{"text":112,"@type":113},"It examines whether age at exposure, time since exposure, or attained age modifies associations between occupational radiation and mortality from multiple cancer categories.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is the radiation effect variation modeled?",{"text":117,"@type":113},"The analysis uses multivariable Poisson regression with general relative rate models to describe modification of the linear excess relative rate per unit organ absorbed dose.",{"name":119,"@type":110,"acceptedAnswer":120},"What are the main findings regarding temporal variation?",{"text":121,"@type":113},"Temporal patterns vary across cancer types, and there is evidence of persistent radiation-associated excess cancer risk decades after exposure; however, statistically significant temporal modification of the radiation effect was not generally observed.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332857,1790052789,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","European Journal of Epidemiology (2024) 39:1277–1286  \n[https://doi.org/10.1007/s10654-024-01](https://doi.org/10.1007/s10654-024-01)178-6  \nCOHORT UPDATE  \nUpdated findings on temporal variation in radiation-effects on cancer mortality in an international cohort of nuclear workers (INWORKS)  \nRobert D. Daniels1 · Stephen J. Bertke1 · Kaitlin Kelly-Reif1 · David B. Richardson2 · Richard Haylock3 · Dominique Laurier4 · Klervi Leuraud4 · Monika Moissonnier5 · Isabelle Thierry-Chef6 · Ausrele Kesminiene5 ·  \nMary K. Schubauer-Berigan5  \nReceived: 28 April 2024 / Accepted: 6 November 2024 / Published online: 22 November 2024  \nThis is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024  \nAbstract  \nThe International Nuclear Workers Study (INWORKS) contributes knowledge on the dose-response association between predominantly low dose, low dose rate occupational exposures to penetrating forms of ionizing radiation and causespecific mortality. By extending follow-up of 309,932 radiation workers from France (1968–2014), the United Kingdom (1955–2012), and the United States (1944–2016) we increased support for analyses of temporal variation in radiationcancer mortality associations. Here, we examine whether age at exposure, time since exposure, or attained age separately modify associations between radiation and mortality from all solid cancers, solid cancers excluding lung cancer, lung cancer, and lymphohematopoietic cancers. Multivariable Poisson regression was used to fit general relative rate models that describe modification of the linear excess relative rate per unit organ absorbed dose. Given indication of greater risk per unit dose for solid cancer mortality among workers hired in more recent calendar years, sensitivity analyses considering the impact of year of hire on results were performed. Findings were reasonably compatible with those from previous pooled and country-specific analyses within INWORKS showing temporal patterns of effect measure modification that varied among cancers, with evidence of persistent radiation-associated excess cancer risk decades after exposure, although statistically significant temporal modification of the radiation effect was not observed. Analyses stratified by hire period (\u003C1958, 1958+) showed temporal patterns that varied; however, these analyses did not suggest that this was due to differences in distribution of these effect measure modifiers by hire year.  \nKeywords Cancer · Epidemiology · Longitudinal studies · Dose-response · Mortality studies  \n􀀍 Robert D. Daniels[rtd2@cdc.gov](rtd2@cdc.gov)  \n1 National Institute for Occupational Safety and Health (NIOSH), 1090 Tusculum Avenue, Mailstop 12, Cincinnati, OH 45226, USA  \n2 Department of Environmental and Occupational Health, Program in Public Health, University of California, Irvine, CA, USA  \n3 UK Health Security Agency, Chilton, Didcot, Oxfordshire, UK  \n4 Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France  \n5 International Agency for Research on Cancer (IARC/WHO), Lyon, France  \n6 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain  \nIntroduction  \nThe International Nuclear Workers’ Study (INWORKS) is alongstanding collaboration coordinated by the International Agency for Research on Cancer (IARC) to examine mortality in a cohort of radiation workers employed in France, the United Kingdom (UK), and the United States (US) [1–12] . These workers have been studied in earlier pooled analyses [13–19] and country-specific analyses, e.g [20–24] . Recent analyses reported positive associations between: colon absorbed dose (in gray, Gy) and all solid cancers [excess relative rate (ERR) Gy–1 = 0.52; 90% confidence interval (CI): 0.27, 0.77] and all solid cancers excluding lung (ERRGy–1 = 0.46; 90% CI 0. 18, 0.76); lung dose and lung cancer (ERR Gy–1 = 0.67; 90% CI 0.21, 1. 19); and red bone marrow (RBM) dose and leukemia excluding","cbCaiq7s8ie1IciX","https://ap.wps.com/l/cbCaiq7s8ie1IciX","pdf",917453,"English","# Abstract\n## Study aims and populations\n## Modeling approach\n## Sensitivity and stratified analyses\n## Key findings","[{\"question\":\"What does the INWORKS study evaluate in this work?\",\"answer\":\"It examines whether age at exposure, time since exposure, or attained age modifies associations between occupational radiation and mortality from multiple cancer categories.\"},{\"question\":\"How is the radiation effect variation modeled?\",\"answer\":\"The analysis uses multivariable Poisson regression with general relative rate models to describe modification of the linear excess relative rate per unit organ absorbed dose.\"},{\"question\":\"What are the main findings regarding temporal variation?\",\"answer\":\"Temporal patterns vary across cancer types, and there is evidence of persistent radiation-associated excess cancer risk decades after exposure; however, statistically significant temporal modification of the radiation effect was not generally observed.\"}]","Updated findings on temporal variation in radiation-effects on cancer mortality in an international cohort of nuclear workers (INWORKS) - COHORT UPDATE | PDF",1789999782,25]