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It further performs a pan-cancer workflow including differential expression, ceRNA, PPI, clinical correlations, tumor purity, genomics, immunity, and drug sensitivity, with gene set enrichment to define enriched pathways.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/unveiling-the-unique-role-of-tspan7-across-tumors-research-open-access/332365/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/unveiling-the-unique-role-of-tspan7-across-tumors-research-open-access/332365.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about TSPAN7?","Question",{"text":63,"@type":64},"The study examines the precise function of TSPAN7 and clarifies its role in pan-cancer contexts, focusing on how it relates to tumor progression and patient outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were TSPAN7 expression and clinical associations evaluated?",{"text":68,"@type":64},"In the Xinhua cohort of 370 kidney neoplasm patients, the study used immunohistochemistry to compare tumor versus normal tissues and evaluated correlations between TSPAN7 and survival.",{"name":70,"@type":61,"acceptedAnswer":71},"What types of analyses are included in the pan-cancer study?",{"text":72,"@type":64},"The study integrates differential expression analysis, ceRNA analysis, protein-protein interaction analysis, associations with clinical characteristics, tumor purity, tumor genomics, tumor immunity, and drug sensitivity, followed by gene set enrichment for pathways.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332365,1790196190,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Lu et al. Biology Direct (2024) 19:72 [https://doi.org/10.1186/s13062-024-00516-8](https://doi.org/10.1186/s13062-024-00516-8)  \nBiology Direct  \nRESEARCH Open Access  \nUnveiling the unique role ofTSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis  \nBingnan Lu 1†, Yifan Liu 1†, Yuntao Yao 1†, Dawei Zhu2†, Xiangmin Zhang3, Keqin Dong 1, Xiao Xu2, Donghao Lv 1, Zihui Zhao 1, Haoyu Zhang 1, Xinyue Yang 1, Wenjia Fu 1, Runzhi Huang4*, Jianwei Cao 1,2*, Jian Chu3*, Xiuwu Pan 1* and Xingang Cui 1*  \nAbstract  \nBackground TSPAN7 is an important factor in tumor progression. However, the precise function ofTSPAN7 and its role in pan-cancer are not clear.  \nMethods Based on Xinhua cohort incorporating 370 patients with kidney neoplasm, we conducted differential expression analysis by immunohistochemistry between tumor and normal tissues, and explored correlationsofTSPAN7 with patients’ survival. Subsequently, we conducted a pan-cancer study, and successively employed differential expression analysis, competing endogenous RNA (ceRNA) analysis, protein-protein interaction (PPI) analysis, correlation analysis ofTSPAN7 with clinical characteristics, tumor purity, tumor genomics, tumor immunity, and drug sensitivity. Last but not least, gene set enrichment analysis was applied to identify enriched pathways of TSPAN7 .  \nResults In Xinhua cohort, TSPAN7 expression was significantly up-regulated (P-value = 0 . 0019) in tumor tissues of kidney neoplasm patients. HighTSPAN7 expression was associated with decreases in overall survival (OS)(P-value = 0 . 009) and progression-free survival (P-value = 0 . 009), and it was further revealed as an independent  \n†Bingnan Lu, Yifan Liu, Yuntao Yao and Dawei Zhu contributed equally to this work and shared first authorship.  \n*Correspondence:  \nRunzhi Huang [runzhihuang2022@163.com](runzhihuang2022@163.com)[ ](runzhihuang2022@163.com)Jianwei Cao [caojianwei8613@xinhuamed.com.cn](caojianwei8613@xinhuamed.com.cn)[ ](caojianwei8613@xinhuamed.com.cn)Jian Chu  \n[doctor_chu@126.com](doctor_chu@126.com)  \nXiuwu Pan  \n[panxiuwu@126.com](panxiuwu@126.com)  \nXingang Cui [cuixingang@xinhuamed.com.cn](cuixingang@xinhuamed.com.cn)  \nFull list of author information is available at the end of the article  \nIntroduction  \nTetraspanins (TSPANs) are a protein family with 33 mammalian members that consists of four transmembrane segments, a large extracellular loop, a small extracellular loop, and a small intracellular loop [1–3]. Large amounts of evidence have demonstrated TSPANs asa facilitator of tumor development [4]. Runzhi Huang et al. discovered the important role of TSPANs in pancancer [5]. Notably, it has been found that TSPAN8 could increase tumor cell stemness through the activation of sonic Hedgehog pathway in breast cancer [6]. Apart from this, high expression of TSPAN13 could induce the  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://](http://)[ ](http://)[creativecommons.org/l](creativecommons.org/l)icenses/by-n","cbCaiaVtjUekmnnL","https://ap.wps.com/l/cbCaiaVtjUekmnnL","pdf",10817070,21,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What question does the study address about TSPAN7?\",\"answer\":\"The study examines the precise function of TSPAN7 and clarifies its role in pan-cancer contexts, focusing on how it relates to tumor progression and patient outcomes.\"},{\"question\":\"How were TSPAN7 expression and clinical associations evaluated?\",\"answer\":\"In the Xinhua cohort of 370 kidney neoplasm patients, the study used immunohistochemistry to compare tumor versus normal tissues and evaluated correlations between TSPAN7 and survival.\"},{\"question\":\"What types of analyses are included in the pan-cancer study?\",\"answer\":\"The study integrates differential expression analysis, ceRNA analysis, protein-protein interaction analysis, associations with clinical characteristics, tumor purity, tumor genomics, tumor immunity, and drug sensitivity, followed by gene set enrichment for pathways.\"}]","Unveiling the unique role of TSPAN7 across tumors - Research Open Access | PDF",1789997860,53]