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This comprehensive study evaluates the therapeutic potential of the Suyin Detoxification Prescription (SDP), a traditional Chinese medicine formulation, using clinical efficacy assessment, network pharmacology, and molecular mechanism exploration. A randomized controlled trial combined with network pharmacology, pathological analysis, immunofluorescence, and Western blot is used to define clinical and preclinical effects. Results show significant improvements in renal function and proteinuria and demonstrate FXR-mediated anti-inflammatory and antioxidant mechanisms, including TNF-α, gp91, and P-MLK1 downregulation.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/unveiling-the-therapeutic-potential-of-suyin-detoxification-prescription-in-diabetic-nephropathy-a-comprehensive-study-integrating-clinical-efficacy-network-pharmacology-and-molecular-mechanisms/437968/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/unveiling-the-therapeutic-potential-of-suyin-detoxification-prescription-in-diabetic-nephropathy-a-comprehensive-study-integrating-clinical-efficacy-network-pharmacology-and-molecular-mechanisms/437968.png","ImageObject",300,407,{"name":42,"@type":43},"Blue Pony","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-01","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the purpose of this study on Suyin Detoxification Prescription (SDP) in diabetic nephropathy?","Question",{"text":62,"@type":63},"To comprehensively evaluate SDP’s therapeutic effects in DN by combining clinical observations with network pharmacology analysis and molecular mechanism exploration.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What methods were used to investigate SDP’s efficacy and mechanisms?",{"text":67,"@type":63},"The study used a randomized controlled trial together with network pharmacology, pathological analysis, immunofluorescence, and Western blot to examine efficacy and mechanisms.",{"name":69,"@type":60,"acceptedAnswer":70},"Which key findings support SDP’s benefits in diabetic nephropathy?",{"text":71,"@type":63},"SDP significantly reduced serum creatinine and proteinuria. Mechanistic work showed downregulation of TNF-α, gp91, and P-MLK1 in renal tissues, and FXR knockout weakened SDP’s renal protective effects.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},437968,1790767291,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},962090760266,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Wiley  \nJournal of Diabetes Research  \nVolume 2025, Article ID 4566357, 15 pages [https://doi.org/10.1155/jdr/4566357](https://doi.org/10.1155/jdr/4566357)  \nResearch Article  \nUnveiling the Therapeutic Potential of Suyin Detoxification Prescription in Diabetic Nephropathy: A Comprehensive Study Integrating Clinical Efficacy, Network Pharmacology, and Molecular Mechanisms  \nTuo Wei , 1,2 Jiebo Huang,3 Bingying Wan,4 Bei Huang,5 Jing Cheng,6 Chao Shi,2 Chen Yong, 1 Yan Li ,2 and Enchao Zhou 1,7  \n1Department of Nephrology, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing City, Jiangsu, China  \n2Department of Traditional Chinese Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu City, Anhui Province, China  \n3Blood Purification Center of Nanjing Pukou District Hospital of Traditional Chinese Medicine, Nanjing City, Jiangsu, China 4Department of Nephrology, Changzhou Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Changzhou City, Jiangsu, China  \n5 The Personnel and Education Department of Ma ’anshan City Hospital of Traditional Chinese Medicine, Ma ’anshan City, Anhui Province, China  \n6Medical Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu City, Anhui Province, China  \n7Key Laboratory of Tonifying Kidney and Anti-Aging, Jiangsu University, Nanjing City, Jiangsu Province, China Correspondence should be addressed to Yan Li; liyan.0301@163.com and Enchao Zhou; [zhouenchao@njucm.edu.cn](zhouenchao@njucm.edu.cn)  \nReceived 17 April 2025; Revised 28 September 2025; Accepted 25 October 2025  \nGuest Editor: Hannah Wesley  \nCopyright © 2025 Tuo Wei et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nBackground: Diabetic nephropathy (DN) is a severe complication of diabetes, characterized by progressive renal dysfunction and proteinuria. Suyin Detoxification Prescription (SDP), a traditional Chinese medicine (TCM) formulation, has shown promising clinical efficacy in alleviating DN symptoms. This study is aimed at comprehensively evaluating the therapeutic effects of SDP through clinical observations, network pharmacology analysis, and molecular mechanism exploration.  \nMethods: This study employed a randomized controlled trial combined with network pharmacology, pathological analysis, immunofluorescence, and Western blot to comprehensively investigate the therapeutic efficacy and mechanisms of SDP in DN treatment.  \nResults: Clinical data revealed that SDP significantly reduces serum creatinine levels (p =0  009) and reduced proteinuria (p =0  03)in DN patients. Network pharmacology successfully established an interaction network among active components of SDP, FXR targets, and DN pathological processes. Experimental validation demonstrated that the formula significantly downregulated TNF-α, gp91, and P-MLK1 expression in renal tissues of diabetic mice. Notably, FXR knockout markedly attenuated the renal protective effects of SDP in DN mice.  \nConclusion: SDP exerts renal protective effects in DN through FXR activation, mitigating oxidative stress and inflammatory damage, while reducing proteinuria and renal function impairment, providing novel therapeutic strategies for DN management.  \nKeywords: diabetic nephropathy; FXR; inflammatory damage; network pharmacology; oxidative stress; SDP  \n2 Journal of Diabetes Research  \nTABLE 1: TCM syndrome rating scale.  \n\n| Symptom | 0\u003Cbr>points\u003Cbr>(none) | 1 point (mild) | 2 points (moderate) | 3 points (severe) |\n| --- | --- | --- | --- | --- |\n| Low back pain | None | Occasional low back pain, does not affect daily activities | Frequent low back pain, barely able to perform daily activities | Severe low back pain, unable to perform daily activities |\n| Fatigue | None | Unable to end","cbCaish1VkizP2R4","https://ap.wps.com/l/cbCaish1VkizP2R4","pdf",6470702,15,"English","# Background\n# Methods\n## Clinical and preclinical components\n# Results\n## Clinical efficacy\n## Network pharmacology and mechanistic validation\n# Conclusion\n# TCM syndrome rating scale","[{\"question\":\"What is the purpose of this study on Suyin Detoxification Prescription (SDP) in diabetic nephropathy?\",\"answer\":\"To comprehensively evaluate SDP’s therapeutic effects in DN by combining clinical observations with network pharmacology analysis and molecular mechanism exploration.\"},{\"question\":\"What methods were used to investigate SDP’s efficacy and mechanisms?\",\"answer\":\"The study used a randomized controlled trial together with network pharmacology, pathological analysis, immunofluorescence, and Western blot to examine efficacy and mechanisms.\"},{\"question\":\"Which key findings support SDP’s benefits in diabetic nephropathy?\",\"answer\":\"SDP significantly reduced serum creatinine and proteinuria. Mechanistic work showed downregulation of TNF-α, gp91, and P-MLK1 in renal tissues, and FXR knockout weakened SDP’s renal protective effects.\"}]","Unveiling the Therapeutic Potential of Suyin Detoxification Prescription in Diabetic Nephropathy - A Comprehensive Study Integrating Clinical Efficacy, Network Pharmacology, and Molecular Mechanisms | PDF",1790683679,38]