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The MAPK signaling pathway coordinates major cellular decisions including proliferation, differentiation, survival, apoptosis, and transformation. This review links tsRNAs to MAPK regulation through protein targeting, summarizing MAPK-linked tsRNAs reported in gastric cancer and high-grade serous ovarian cancer and extending KEGG-supported roles across multiple non-cancer diseases, including varicose vein risk, spinal cord injury, diabetes-related disorders, keloid formation, intervertebral disk degeneration, systemic lupus erythematosus, lupus nephritis, acute lung injury, and more.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-the-role-of-trna-derived-small-rnas-in-mapk-signaling-pathway-implications-for-cancer-and-beyond/331982/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-the-role-of-trna-derived-small-rnas-in-mapk-signaling-pathway-implications-for-cancer-and-beyond/331982.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are tRNA-derived small RNAs (tsRNAs) and where do they come from?","Question",{"text":113,"@type":114},"tsRNAs are small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do tsRNAs influence the MAPK signaling pathway?",{"text":118,"@type":114},"tsRNAs affect MAPK signaling by targeting specific proteins within the pathway, thereby modulating MAPK pathway activity and downstream cellular outcomes.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cancer and non-cancer conditions does the review connect to MAPK-linked tsRNAs?",{"text":122,"@type":114},"The review highlights MAPK-linked tsRNAs in gastric cancer and high-grade serous ovarian cancer, and also summarizes associations reported across several non-cancer diseases, including varicose vein risk, spinal cord injury, diabetes-related disorders, lupus-related conditions, acute lung injury, and others.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331982,1790192530,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 26 March 2024  \nDOI 10.3389/fgene.2024.1346852  \nOPEN ACCESS  \nEDITED BY  \nSubhashree Nayak,  \nNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH), United States  \nREVIEWED BY  \nJiangxin Wang,  \nShenzhen University, China Amrita Singh,  \nYale University, United States  \n*CORRESPONDENCE  \nShiwei Duan,  \n [duansw@hzcu.edu.cn](duansw@hzcu.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 30 November 2023  \nACCEPTED 13 March 2024  \nPUBLISHED 26 March 2024  \nCITATION  \nWang Q, Huang Q, Ying X, Shen J and Duan S (2024), Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond.  \nFront. Genet. 15:1346852 .  \ndoi: 10.3389/fgene.2024.1346852  \nCOPYRIGHT  \n© 2024 Wang, Huang, Ying, Shen and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nUnveiling the role of  \ntRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond  \nQurui Wang 1†, Qinyuan Huang 1†, Xiaowei Ying 1, Jinze Shen 1 and Shiwei Duan 1,2*  \n1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China, 2Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China  \ntRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC) . Notably, tRF-Glu-TTC-027 and tRF-Val-CAC- 016 modulate MAPK-related protein expression, encompassing p38, Myc, ERK, CyclinD1, CyclinB, and c-Myc, hindering GC progression via MAPK pathway inhibition. Moreover, tRF-24-V29K9UV3IU and tRF-03357 remain unexplored in specific mechanisms. KEGG analysis posits varied tsRNAs in MAPK pathway modulation for diverse non-cancer maladies. Notably, high tRF-36-F900BY4D84KRIME and tRF-23-87R8WP9IY expression relates to varicose vein (VV) risk. Elevated tiRNA-Gly-GCC-001, tRF-Gly-GCC-012, tRF-Gly-GCC- 013, and tRF-Gly-GCC-016 target spinal cord injury (SCI)-related brain-derived neurotrophic factor (BDNF), influencing MAPK expression. tRF-Gly-CCC- 039 associates with diabetes foot sustained healing, while tRF-5014a inhibits autophagy-linked ATG5 in diabetic cardiomyopathy (DCM) . Additionally, tsRNA- 14783 influences keloid formation by regulating M2 macrophage polarization. Upregulation of tRF-Arg-ACG-007 and downregulation of tRF-Ser-GCT-008 are associated with diabetes. tsRNA-04002 alleviates Intervertebral disk degeneration (IDD) by targeting PRKCA. tsRNA-21109 alleviates Systemic lupus erythematosus (SLE) by inhibiting macrophage M1 polarization. The upregulated tiNA-Gly-GCC-002 and the downregulated tRF-Ala-AGC-010, tRF-Gln-CTG- 005 and tRF-Leu-AAG-001 may be involved in the pathogenesis of Lupus nephritis (LN) by affecting the expression of MAPK pathway. Downregulation of tsRNA-1018, tsRNA-3045b, tsRNA-5021a and tsRNA-1020 affected the expression of MAPK pathway, thereby improving Acute lung injury (ALI) . This review comprehensively dissects tsRNA roles in MAPK signaling across cancersand other diseases, illuminating a novel avenue for translational","cbCaim06SvOC8Zz9","https://ap.wps.com/l/cbCaim06SvOC8Zz9","pdf",2652388,14,"English","# Introduction\n## Overview of MAPK signaling cascade\n## MAPK pathway components and upstream regulators\n## tRNA-derived small RNAs (tsRNAs) subclasses and gene regulation","[{\"question\":\"What are tRNA-derived small RNAs (tsRNAs) and where do they come from?\",\"answer\":\"tsRNAs are small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt.\"},{\"question\":\"How do tsRNAs influence the MAPK signaling pathway?\",\"answer\":\"tsRNAs affect MAPK signaling by targeting specific proteins within the pathway, thereby modulating MAPK pathway activity and downstream cellular outcomes.\"},{\"question\":\"Which cancer and non-cancer conditions does the review connect to MAPK-linked tsRNAs?\",\"answer\":\"The review highlights MAPK-linked tsRNAs in gastric cancer and high-grade serous ovarian cancer, and also summarizes associations reported across several non-cancer diseases, including varicose vein risk, spinal cord injury, diabetes-related disorders, lupus-related conditions, acute lung injury, and others.\"}]","Unveiling the Role of tRNA-derived Small RNAs in MAPK Signaling Pathway: Implications for Cancer and Beyond | PDF",1789996127,35]