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The review synthesizes current knowledge on HPV biology and host interactions, including co-infections with viruses such as HIV, EBV, and HSV and emerging influence of the microbiome. It summarizes recent evidence linking HPV to cancers of anogenital and head-and-neck regions as well as breast, lung, and prostate disease. Preventive and therapeutic strategies are discussed, spanning vaccination and screening to surgery, chemotherapy, targeted therapy, and immunotherapy, with future research directions highlighted.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-the-multifaceted-realm-of-human-papillomavirus-a-comprehensive-exploration-of-biology-interactions-and-advances-in-cancer-management/328590/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-the-multifaceted-realm-of-human-papillomavirus-a-comprehensive-exploration-of-biology-interactions-and-advances-in-cancer-management/328590.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does persistent HPV infection play in cancer development?","Question",{"text":112,"@type":113},"Persistent HPV infection is described as a significant etiological factor for a range of malignancies, with an established relationship to tumor development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the review address interactions between HPV and other viruses or the microbiome?",{"text":117,"@type":113},"It examines complex dynamics of co-infections involving HPV alongside HIV, EBV, and HSV, and highlights the growing role of the microbiome in cancer development.",{"name":119,"@type":110,"acceptedAnswer":120},"What prevention and treatment strategies are covered for HPV-associated cancers?",{"text":121,"@type":113},"The review covers preventive approaches including vaccination and screening, and therapeutic interventions ranging from surgery and chemotherapy to targeted therapies and immunotherapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328590,1790088500,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 08 August 2024  \nDOI 10.3389/fimmu.2024.1430544  \nOPEN ACCESS  \nEDITED BY  \nSrivastava Vartika,  \nCleveland Clinic, United States  \nREVIEWED BY  \nMarcela Lizano,  \nNational Cancer Institute, Mexico Raghvendra M. Srivastava, Cleveland Clinic, United States  \n*CORRESPONDENCE Wei Li  \n [weili126@126.com](weili126@126.com)[ ](weili126@126.com)Man Tian  \n [tmsweet@163.com](tmsweet@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 10 May 2024  \nACCEPTED 24 July 2024  \nPUBLISHED 08 August 2024  \nCITATION  \nWu M, Huang H, Tang Y, Ren X, Jiang X, Tian M and Li W (2024) Unveiling the multifaceted realm of human papillomavirus:  \na comprehensive exploration of biology, interactions, and advancesin cancer management.  \nFront. Immunol. 15:1430544 .  \ndoi: 10.3389/fimmu.2024.1430544  \nCOPYRIGHT  \n© 2024 Wu, Huang, Tang, Ren, Jiang, Tian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nUnveiling the multifaceted realm of human papillomavirus: a comprehensive exploration of biology, interactions, and advances in cancer management  \nMeng Wu 1†, Hui Huang 2†, Ying Tang 3†, Xuze Ren 4, Xinrui Jiang 5, Man Tian 6* and Wei Li 7*  \n1 Department of Clinical Laboratory, Children ’s Hospital of Nanjing Medical University, Nanjing, China, 2 Department of Rheumatology and Immunology, Children ’s Hospital of Nanjing Medical University, Nanjing, China, 3 Department of Ultrasound Diagnostic, Children ’s Hospital of Nanjing Medical University, Nanjing, China, 4 Department of Clinical Medicine, Clinical College of Anhui Medical University, Hefei, China, 5 Department of Neurology, Children ’s Hospital of Nanjing Medical University, Nanjing, China, 6 Department of Respiratory, Children ’s Hospital of Nanjing Medical University, Nanjing, China, 7 Department of Clinical Research, Children ’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China  \nHuman Papillomavirus (HPV), an extensive family of DNA viruses, manifests as a persistent global health challenge. Persistent HPV infection is now firmly established as a significant aetiological factor for a spectrum of malignancies. In this review, we examine the latest insights into HPV biology and its intricate relationship with the host. We delve into the complex dynamics of co-infections involving HPV alongside other viruses, such as HIV, EBV, and HSV, as well as the burgeoning role of the microbiome in cancer development. We also explore recent advancements in understanding the specific contributions of HPV in the development of various cancers, encompassing cancers of the anogenital region, head and neck, as well as breast, lung, and prostate. Moreover, we focus on the current preventive strategies, including vaccination and screening methods, and therapeutic interventions that range from traditional approaches like surgery and chemotherapy to emerging modalities such as targeted therapies and immunotherapies. Additionally, we provide a forward-looking view on the future directions of HPV research, highlighting potential areas of exploration to further our understanding and management of HPV and its associated cancers. Collectively, this review is positioned to deepen readers’understanding of HPV biology and its complex interplay with cancer biology. It presents innovative strategies for the prevention, management, and therapeutic intervention of HPV-associated malignancies.  \nKEYWORDS  \nHPV, HPV-associated cancers, HPV vaccines, microRNA, cancer prevention  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nCancer is a sig","cbCailAt0aqW77kt","https://ap.wps.com/l/cbCailAt0aqW77kt","pdf",1863611,14,"English","# Introduction\n## Global burden and viral oncogenesis\n# HPV biology and host interactions\n## Co-infections and microbiome involvement\n# HPV-associated cancer types\n## Anogenital region, head and neck, and other cancers\n# Prevention and treatment advances\n## Vaccination, screening, and therapeutic modalities\n# Future directions in HPV research","[{\"question\":\"What role does persistent HPV infection play in cancer development?\",\"answer\":\"Persistent HPV infection is described as a significant etiological factor for a range of malignancies, with an established relationship to tumor development.\"},{\"question\":\"How does the review address interactions between HPV and other viruses or the microbiome?\",\"answer\":\"It examines complex dynamics of co-infections involving HPV alongside HIV, EBV, and HSV, and highlights the growing role of the microbiome in cancer development.\"},{\"question\":\"What prevention and treatment strategies are covered for HPV-associated cancers?\",\"answer\":\"The review covers preventive approaches including vaccination and screening, and therapeutic interventions ranging from surgery and chemotherapy to targeted therapies and immunotherapies.\"}]","Unveiling the multifaceted realm of human papillomavirus - A comprehensive exploration of biology, interactions, and advances in cancer management | PDF",1789980341,35]