[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332097-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332097-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","unveiling-the-intratumoral-microbiota-within-cancer-landscapes","Unveiling the intratumoral microbiota within cancer landscapes","","Recent cancer research reveals an underappreciated dimension of oncology: intratumoral microbiota. This review synthesizes findings on microbial residents—bacteria, fungi, and viruses—within tumor tissues and how they shape tumor development, progression, and responses to therapy. It integrates evidence on identification and characterization methods as well as functional roles, emphasizing complex interactions between microbes and the tumor microenvironment. 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These microbial residents, encompassing bacteria, fungi, and viruses within tumor tissues, have been found to exert considerable influence on tumor development, progression, and the efficacy of therapeutic interventions. This review aims to synthesize these groundbreaking discoveries, providing an integrated overview of the identification, characterization, andfunctional roles of intratumoral microbiota in cancer biology. Wefocus on elucidatingthe complex interactions between these microorganisms and the tumor microenvironment, highlighting their potential as novel biomarkers and therapeutic targets. The purpose of this review is to offer a comprehensive understanding of the microbial dimension in cancer, paving the way for innovative approaches in cancer diagnosis and treatment.  \nINTRODUCTION  \nCancer arises as a multifactorial disease influenced by a synergy of genetic factors, environmental conditions, and individual lifestyle choices. Recent advancements in cancer research have marked significant progress, particularly in the modulation of the cancer immune microenvironment, the exploration of immune checkpoints such as PD-1, PD-L1, CTLA-4, CD47, CD24, and CD39, and the application of CAR-T therapy.1–3 These developments highlight a pivotal shift toward targeting the complex interplay between cancer cells and the immune system, aiming to enhance the body ability to recognize and combat malignancies. Additionally, novel research into mechanisms of cell death, including ferroptosis and cuproptosis, has also opened new avenues for therapeutic intervention.4–6 Together, these cutting-edge approaches reflect the dynamic and rapidly evolving landscape of oncology research, with the potential to significantly improve patient outcomes, and pave the way for next-generation cancer therapies.7,8 Variability in tumor bacterial content, shaped by genetic makeup and external environmental influences, contributes to divergent tumor structural and functional properties, complicating treatment approaches. The tumor microenvironment constitutes the ecological niche enveloping the tumor, encompassing adjacent blood vessels, immune cells,fibroblasts, bone-marrow-derived inflammatory cells, a range of signaling molecules, and the extracellular matrix (ECM) . This microenvironment is pivotal in the initiation and advancement of cancer. Variability in tumor bacterial content, shaped by genetic makeup and external environmental influences, contributes to divergent tumor structural and functional properties, complicating treatment approaches.9 The tumor microenvironment constitutes the ecological niche enveloping the tumor, encompassing adjacent blood vessels, immune cells, fibroblasts, bone-marrow-derived inflammatory cells, a range of signaling molecules, and the extracellular matrix (ECM) . This microenvironment is pivotal in the initiation and advancement of cancer.  \nThe intricate relationship between cancer and its microenvironment has long been a subject of intense scientific scrutiny. Recently, this exploration has expanded beyond the traditional focus on cancer cells and their immediate surroundings to include a less visible, yet potentially pivotal component—the intratumoral microbiota.10–13 The evolution from focusing on the tumor microenvironment to the tumor microbe microenvironment (TMEM) marks a pivotal development in our understanding of cancer (Figure 1) . This shift emphasizes the integral role of microbial communities, comprising bacteria, viruses, and fungi, which reside within tumors and significantly influence cancer progression, metastasis, and therapeutic outcomes. It highlights the intricate interaction","cbCaidVO70kmnVf5","https://ap.wps.com/l/cbCaidVO70kmnVf5","pdf",6170232,23,"English","# Summary\n# Introduction\n# Tumor Microenvironment and Tumor Microbe Microenvironment\n# Impact on Cancer Onset, Progression, Diagnosis, and Therapy","[{\"question\":\"What is intratumoral microbiota and why is it important in cancer?\",\"answer\":\"Intratumoral microbiota refers to bacteria, fungi, and viruses residing within tumor tissues. The review explains that these microbes can significantly influence tumor development, progression, and treatment efficacy by interacting with the tumor microenvironment and immune responses.\"},{\"question\":\"How does the tumor microenvironment relate to the tumor microbe microenvironment?\",\"answer\":\"The tumor microenvironment is described as an ecological niche containing blood vessels, immune cells, fibroblasts, signaling molecules, and extracellular matrix. The review highlights a shift toward considering the tumor microbe microenvironment (TMEM), where microbial communities interact with tumor cellular components to affect cancer behavior and treatment strategies.\"},{\"question\":\"What roles could intratumoral microbiota play in diagnosis and treatment?\",\"answer\":\"The review emphasizes the potential of intratumoral microbiota as diagnostic and prognostic tools. It also outlines opportunities to develop microbiome-based therapies and diagnostics by targeting the tumor microbe microenvironment to improve therapeutic outcomes.\"}]","Unveiling the intratumoral microbiota within cancer landscapes | PDF",1789996755,58]