[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370782-105":59,"doc-detail-370782-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","unveiling-the-impact-of-ovol1-on-prognosis-immune-microenvironment-and-proliferation-in-pancreatic-cancer","Unveiling the impact of OVOL1 on prognosis, immune microenvironment, and proliferation in pancreatic cancer","","OVO-like protein 1 (OVOL1) is linked to progression in multiple cancers, but its prognostic and immunological relevance in pancreatic cancer remained unclear. Using multiple patient cohorts, OVOL1 was found upregulated in pancreatic cancer and associated with worse overall survival, disease-specific survival, and progression-free interval. High OVOL1 coincided with reduced infiltration of CD8 T cells, NK cells, and cytotoxic immune cells, alongside increased tumor mutation burden. Functional assays showed OVOL1 knockdown suppresses proliferation and inhibits ERK/JNK/p38 MAPK signaling, while OVOL1 hypomethylation predicted poor outcomes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-the-impact-of-ovol1-on-prognosis-immune-microenvironment-and-proliferation-in-pancreatic-cancer/370782/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-the-impact-of-ovol1-on-prognosis-immune-microenvironment-and-proliferation-in-pancreatic-cancer/370782.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What clinical associations were found for OVOL1 in pancreatic cancer patients?","Question",{"text":113,"@type":114},"Higher OVOL1 expression correlated with poorer overall survival, disease-specific survival, and progression-free interval. OVOL1 upregulation was also linked to increased tumor mutation burden.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does OVOL1 expression relate to the immune microenvironment?",{"text":118,"@type":114},"Elevated OVOL1 was associated with decreased immune cell infiltration, including CD8 T cells, NK cells, and cytotoxic cells.",{"name":120,"@type":111,"acceptedAnswer":121},"What biological mechanism was suggested for OVOL1’s role in pancreatic cancer proliferation?",{"text":122,"@type":114},"OVOL1 knockdown reduced pancreatic cancer cell proliferation and inhibited the ERK/JNK/p38 MAPK signaling pathway. OVOL1 was also reported to be hypomethylated, with low methylation predicting worse outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370782,1790664803,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nUnveiling the impact of OVOL1 on prognosis, immune microenvironment, and proliferation in pancreatic cancer  \nJinping Li1,5, Zhenyan Deng2,5, Zhaofang Yan3,4, Shuxian Huang3,4, Jiamin Jin3,4, Chichu Xie3,4 & Jinfeng Gan3,4􀀍  \nOVO-like protein 1 (OVOL1) has been implicated in the progression of various human cancers; however, the prognostic and immunological significance, as well as its biological role in pancreatic cancer, are unknown. In this study, by analyzing multiple patient cohorts, OVOL1 was found to be elevated in pancreatic cancer, which was associated with poor overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI). Two nomogram survival models for predicting  \n1-, 2-, and 3-year OS and DSS with excellent accuracy were constructed, respectively. Tumors with elevated OVOL1 expression showed decreased immune cell infiltration, including CD8 T cells, NK cells, and cytotoxic cells, and increased tumor mutation burden (TMB) . Enrichment analysis revealed that OVOL1 was related to various biological terms and signaling pathways. Knockdown of OVOL1 reduced the proliferation of pancreatic cancer cells and inhibited the ERK/JNK/p38 MAPK signaling pathway. Furthermore, OVOL1 was revealed to be hypomethylated in pancreatic cancer, with low levels of OVOL1 methylation predicting poor outcomes. Our findings suggest that upregulation of OVOL1 has prognostic value and is associated with the unfavorable immune microenvironment in pancreatic cancer. OVOL1 is crucial for pancreatic cancer cell proliferation, which could be attributed to its effect on the ERK/JNK/p38 MAPK signaling pathway.  \nKeywords OVOL1, Pancreatic cancer, Prognosis, Immune microenvironment, Proliferation, MAPK signaling pathway  \nPancreatic cancer is associated with an extremely poor prognosis and is the seventh leading cause of cancerrelated deaths worldwide; by 2025, it is expected to surpass breast cancer as the leading major cause of cancer death1. The dismal prognosis is primarily due to late diagnosis and poor response to cytotoxic therapy, with a 5-year survival rate of only approximately 9%2. Immunotherapy is a promising option for many types of solid tumors3; however, it only benefits just a few percent of pancreatic cancer patients4,5. Therefore, biomarkers for selecting patients for immune checkpoint inhibitors and therapeutic targets are urgently needed.  \nOVO-like protein 1 (OVOL1) is a member of the OVO-like proteins (OVOLs) family, a C2H2 zincfinger transcription factor family that includes three members: OVOL1, OVOL2, and OVOL36. OVOL1 was the first OVOL protein to be identified6, and functional investigations of OVOL1 have revealed its important role in epithelial tissue development7,8, preventing epithelial-mesenchymal transition (EMT) during epithelial differentiation9. OVOL1 is aberrantly expressed in multiple cancer types10–13. OVOL1 expression is downregulated in clear cell renal cell carcinoma10 and nasopharyngeal carcinoma11, and its levels decrease as cutaneous melanoma progresses12. However, bioinformatics investigations have revealed that OVOL1 expression is elevated in some cancer types13. Furthermore, OVOL1 has been demonstrated to be associated with patient prognosis in breast cancer14, cutaneous melanoma12, and clear cell renal cell carcinoma10. Functionally, OVOL1 inhibits the malignant progression of breast cancer by enhancing TGF-β type I receptor degradation14 and  \n1Department of Histology and Embryology, School of Preclinical Medicine, Guilin Medical University, Guilin, China.  \n2Department of Clinical Laboratory, Guilin Hospital of the Second Xiangya Hospital of Central South University, Guilin, China. 3Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China. 4Guangxi Health Commission Key Laboratory of Tumor Immunology and ReceptorTargeted Drug Basi","cbCaimqkv6DozOwy","https://ap.wps.com/l/cbCaimqkv6DozOwy","pdf",7878628,14,"English","# Results\n## OVOL1 expression is upregulated in pancreatic cancer and has diagnostic potential","[{\"question\":\"What clinical associations were found for OVOL1 in pancreatic cancer patients?\",\"answer\":\"Higher OVOL1 expression correlated with poorer overall survival, disease-specific survival, and progression-free interval. OVOL1 upregulation was also linked to increased tumor mutation burden.\"},{\"question\":\"How does OVOL1 expression relate to the immune microenvironment?\",\"answer\":\"Elevated OVOL1 was associated with decreased immune cell infiltration, including CD8 T cells, NK cells, and cytotoxic cells.\"},{\"question\":\"What biological mechanism was suggested for OVOL1’s role in pancreatic cancer proliferation?\",\"answer\":\"OVOL1 knockdown reduced pancreatic cancer cell proliferation and inhibited the ERK/JNK/p38 MAPK signaling pathway. OVOL1 was also reported to be hypomethylated, with low methylation predicting worse outcomes.\"}]","Unveiling the impact of OVOL1 on prognosis, immune microenvironment, and proliferation in pancreatic cancer | PDF",1790190316,35]