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A comprehensive retrospective cross-sectional analysis evaluates 36 cancer types across genders and four age groups, quantifying population risks of cancer diagnosis and death. Findings show age-driven concentration of burden in middle-aged and geriatric groups, with female mortality rising faster than males, and projections indicating continued growth over the next two decades.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-the-cancer-epidemic-in-india-a-glimpse-into-globocan-2022-and-past-patterns/368275/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-the-cancer-epidemic-in-india-a-glimpse-into-globocan-2022-and-past-patterns/368275.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the study on India’s cancer burden?","Question",{"text":112,"@type":113},"To analyze the current cancer burden in India across age groups, estimate the population risk of cancer diagnosis and death, and project future burden aligned with past mortality patterns.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data and analytic approach are used to estimate cancer trends?",{"text":117,"@type":113},"The study uses the GLOBOCAN 2022 database to assess 36 cancer types by gender and four age groups, and applies Multijoinpoint regression to evaluate past mortality patterns from 2000–2022 and forecast future cancer landscape.",{"name":119,"@type":110,"acceptedAnswer":120},"How does cancer burden differ by age group and gender?",{"text":121,"@type":113},"The middle-aged and geriatric cohorts account for the heaviest share of cancer burden, while females show higher crude incidence and crude mortality than males. Cancer-related mortalities increased faster among females than males over the past decade.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},368275,1790719145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Articles   \nUnveiling the cancer epidemic in India: a glimpse into GLOBOCAN 2022 and past patterns  \nKhushwant Singh, Ashoo Grover, and Kavitha Dhanasekaran∗  \nDivision of Implementation Research, Indian Council of Medical Research (ICMR), Headquarters, New Delhi, 110029, India  \nSummary  \nBackground The Global Cancer Observatory (GLOBOCAN) 2022 estimates highlight cancer as a significant global health problem. In the South-East Asia-region, India ranks third in terms of cancer incidence, second for mortality, and 121 in terms of crude rates globally. As cancer risks increase with age, particularly affecting older individuals, this study explores the current cancer burden in India by analyzing the cancer landscape across different age groups, determining the population’s risk of cancer diagnosis and death, and projecting the future cancer burden aligned with past mortality patterns.  \nMethods This is a comprehensive-retrospective, cross-sectional study examining 36 cancer types, by gender, and across four-distinct age groups (childhood, reproductive, middle age, geriatric) in India, using the GLOBOCAN 2022 database. The study further analyzes the past mortality patterns (2000–2022) and future cancer landscape of India by determining annual percent change (APC), through Multijoinpoint regression analysis.  \nFindings The five most prevalent cancers affecting both genders collectively account for 44% of cancer burden in India. Notably, females exhibit higher crude incidence (104.5) and crude mortality (64.2) rates compared to males (91.5 and 62.2), based on 0.676 billion females and 0.731 billion males’ populations in 2022 . The middle-aged and geriatric-cohorts account the heaviest (70%) cancer burden with higher crude rates (315.9–543.1 incidents, 215.6–407.8 mortalities) . Alarmingly, cancer-related mortalities have increased faster among females (1.2–4.4% APC) than males (1.2–2.4% APC) over the past decade, and are expected to continue rising over coming two decades.  \nInterpretation Approximately three out of every five individuals in India succumb to death following a cancer diagnosis, as per the GLOBOCAN 2022 incidence (1,413,316) to mortality (916,827) ratio. Childhood and reproductive age-group individuals bear the lowest risk of developing (0.12–2.4%) and dying (0.08–1.3%) from cancer compared to their middle-aged and geriatric counterparts, having highest risks of developing (8.3–10.3%) and dying (5.5–7.7%) from cancer. As the population of India transitions from the reproductive age group to the middle age and geriatric age group, the India is anticipated to witness the highest cancer burden of all-time in near future, potentially exacerbated by the looming epidemic.  \nFunding No funding received.  \nCopyright © 2025 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ([http://](http://)[ ](http://)[creativecommons.org/licenses/by-nc-nd/4.0/](creativecommons.org/licenses/by-nc-nd/4.0/)).  \nKeywords: Gender disparities in cancer; Cancer epidemiology; Cancer demographics; Demographic changes and cancer mortality; Past cancer mortality trends; Future projections of cancer  \nIntroduction  \nIn the last two decades, the life expectancy in India has increased by 5.6 years (9%) from 62.1 years in 2000 to 67.7 years in 2024 .1 Historically, communicable diseases were the leading contributors to mortalities in India.  \nHowever, with socio-economic development and a concomitant increase in life expectancy, noncommunicable diseases such as cardiovascular disease, stroke, diabetes-mellitus, and cancer have emerged assignificant public health problems in India.2 Between  \nAbbreviation: ASRs, Age-standardized rates; CR, Crude rate; CMR, Crude mortality rate; ASMRs, Age-standardized mortality rates; GHO, Global health observatory; GLOBOCAN, Global cancer observatory; WHO, World health organization; ICD-10, International classification of diseases, 10th revision; NMSC, Non-melanoma skin cancer; CIR, Crude","cbCaijBA8twjUcGb","https://ap.wps.com/l/cbCaijBA8twjUcGb","pdf",2477393,11,"English","# Summary\n## Background\n## Methods\n## Findings\n## Interpretation\n## Funding\n## Keywords\n# Research in context\n## Evidence before this study\n## Added value of this study","[{\"question\":\"What is the main purpose of the study on India’s cancer burden?\",\"answer\":\"To analyze the current cancer burden in India across age groups, estimate the population risk of cancer diagnosis and death, and project future burden aligned with past mortality patterns.\"},{\"question\":\"Which data and analytic approach are used to estimate cancer trends?\",\"answer\":\"The study uses the GLOBOCAN 2022 database to assess 36 cancer types by gender and four age groups, and applies Multijoinpoint regression to evaluate past mortality patterns from 2000–2022 and forecast future cancer landscape.\"},{\"question\":\"How does cancer burden differ by age group and gender?\",\"answer\":\"The middle-aged and geriatric cohorts account for the heaviest share of cancer burden, while females show higher crude incidence and crude mortality than males. Cancer-related mortalities increased faster among females than males over the past decade.\"}]","Unveiling the cancer epidemic in India - a glimpse into GLOBOCAN 2022 and past patterns | PDF",1790175988,28]