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This study performs integrated multi-omics analysis using TCGA and single-cell GEO data across 33 cancer types. Transcriptomic, genomic, and methylation profiles evaluate links with patient survival, gene ontology, tumor-infiltrating lymphocytes, and drug responses, including associations of copy number variation and methylation with dysregulated KLHL23 expression. Results connect KLHL23 with prognosis in hepatocellular carcinoma and indicate biomarker potential through immune activity and chemotherapy sensitivity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-klhl23-as-a-key-immune-regulator-in-hepatocellular-carcinoma-through-integrated-analysis-research-paper/329797/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-klhl23-as-a-key-immune-regulator-in-hepatocellular-carcinoma-through-integrated-analysis-research-paper/329797.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What datasets and approaches are used to study KLHL23?","Question",{"text":112,"@type":113},"The analysis integrates TCGA data with single-cell GEO data, applying multi-omics methods across transcriptomic, genomic, and methylation layers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is KLHL23 linked to patient outcomes in cancers?",{"text":117,"@type":113},"KLHL23 expression correlates with survival, with noted relevance to hepatocellular carcinoma and low-grade glioma.",{"name":119,"@type":110,"acceptedAnswer":120},"What molecular relationships are examined for KLHL23 regulation?",{"text":121,"@type":113},"The study evaluates how copy number variations and methylation relate to dysregulated KLHL23 expression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329797,1790182294,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1794309523707217728","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 22  \nResearch Paper  \nUnveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis  \nLiangliang Xu1,2,*, Bo Li3,*, Yuchen Liu4,*, Zhengming Hu1, Qing Dan1, Bingxuan Xu1, Hongjin Xiang1, Yun Chen1, Tingting Zheng1, Desheng Sun1, Li Liu1  \n1Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Department of Ultrasound, Institute of Ultrasonic Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China  \n2 Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China 3Guangdong-Hong Kong-Macau University Joint Laboratory of Digestive Cancer Research, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, China  \n4Guangdong Provincial Key Laboratory of Digestive Cancer Research, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China  \n* Equal contribution and share first authorship  \nCorrespondence to: Tingting Zheng, Desheng Sun, Li Liu; email: [kyzs_018@126.com](kyzs_018@126.com), [https://orcid.org/0000-0003-0424-0231](https://orcid.org/0000-0003-0424-0231);  \n[szdssun@163.com](szdssun@163.com), [https://orcid.org/0000-0003-0328-1197](https://orcid.org/0000-0003-0328-1197); [liuli@pkuszh.com](liuli@pkuszh.com)  \nKeywords: pan-cancer analysis, KLHL23, hepatocellular carcinoma, prognosis, invasion and metastasis  \nReceived: February 10, 2024 Accepted: October 22, 2024 Published: December 4, 2024  \nCopyright: © 2024 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nAge-related cancers are characterized by impaired protein homeostasis, where Kelch protein superfamily members have showed accumulating clues as critical regulators. In this paper, the cancerous role of Kelch-like family member 23 (KLHL23) was comprehensively analyzed with TCGA and single cell GEO database across overall 33 cancer types. By multi-omics analysis upon the transcriptomic, genomic, and methylation data, the current study explored the association of KLHL23 with patient survival, gene ontology, tumor-infiltrating lymphocytes, and drug responses. The correlation of copy number variations and methylation with dysregulated expression of KLHL23 were also addressed. Notably, KLHL23 levels correlated with survival in cancers such as hepatocellular carcinoma and low-grade glioma. The study also highlighted how reduced KLHL23 expression is linked to increased immune activity and sensitivity to chemotherapy, suggesting its potential as a biomarker for cancer prognosis and treatment responsiveness.  \nINTRODUCTION  \nKelch-like family member 23 (KLHL23) is a gene encoding a member of the Kelch-like protein family [1] . These proteins are characterized by their Kelch motifs, which are composed of multiple β-propeller domains, and typically play multiple roles in various cellular processes, including regulation of protein homeostasis which correlated to aging and cancer [2] . The KLHL23 gene is located on chromosome 7 and is part of the larger family of Kelch-like genes, which are  \nknown for their involvement in the ubiquitinproteasome system. This system is of paramount importance for protein degradation and turnover within the cell, thus ensuring the maintenance of cellular protein homeostasis [3, 4] . The precise functions of KLHL23 remain to be elucidated, yet its potential role in cancer biology is a subject of ongoing investigation [5, 6] . Changes in the expression or mutation of the KLHL23 gene may have implications for cell proliferation, apoptosis, and other dysregulated pathways during oncoge","cbCailJFm1TW3Axc","https://ap.wps.com/l/cbCailJFm1TW3Axc","pdf",4562846,"English","# Abstract\n## Introduction\n## Materials and Methods\n### Data collection and processing","[{\"question\":\"What datasets and approaches are used to study KLHL23?\",\"answer\":\"The analysis integrates TCGA data with single-cell GEO data, applying multi-omics methods across transcriptomic, genomic, and methylation layers.\"},{\"question\":\"How is KLHL23 linked to patient outcomes in cancers?\",\"answer\":\"KLHL23 expression correlates with survival, with noted relevance to hepatocellular carcinoma and low-grade glioma.\"},{\"question\":\"What molecular relationships are examined for KLHL23 regulation?\",\"answer\":\"The study evaluates how copy number variations and methylation relate to dysregulated KLHL23 expression.\"}]","Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis - Research Paper | PDF",1789985664,48]