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Lin et al identified activin A receptor type 1C polymorphisms (rs4556933/rs77886248) as esophageal squamous cell carcinoma risk modifiers in Chinese Han populations through a case-control study (1264 patients/1361 controls), revealing transforming growth factor-beta pathway-mediated susceptibility in older male smokers (P \u003C 0.001). Luo et al established imaging-based differentiation of pancreatic cancer subtypes via retrospective analysis of 500 cases (AUC = 0.89), enabling earlier intervention. Findings highlight precision screening by combining genetic risk stratification with advanced imaging to address outcome gaps.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-genetic-susceptibility-in-esophageal-squamous-cell-carcinoma-and-revolutionizing-pancreatic-cancer-diagnosis-through-imaging/371575/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-genetic-susceptibility-in-esophageal-squamous-cell-carcinoma-and-revolutionizing-pancreatic-cancer-diagnosis-through-imaging/371575.png","ImageObject",300,407,{"name":92,"@type":93},"Sarah ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What genetic variant is linked to esophageal squamous cell carcinoma risk in the Lin et al study?","Question",{"text":112,"@type":113},"Activin A receptor type 1C polymorphisms (rs4556933/rs77886248) were identified as risk modifiers in Chinese Han populations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the Luo et al study differentiate pancreatic cancer subtypes?",{"text":117,"@type":113},"It uses imaging-based differentiation between pancreatic ductal adenocarcinoma and neuroendocrine tumors, validated by retrospective analysis and reporting an AUC of 0.89.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is combining genetic risk stratification with imaging emphasized?",{"text":121,"@type":113},"The document argues this combination enables earlier detection and more personalized screening and therapeutic strategies, improving outcomes where current diagnosis is often late.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},371575,1790813769,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 June 15; 17(6): 102544  \nDOI: 10.4251/wjgo.v17.i6.102544 ISSN 1948-5204 (online)  \nEDITORIAL  \nUnveiling genetic susceptibility in esophageal squamous cell carcinoma and revolutionizing pancreatic cancer diagnosis through imaging  \nSheng-Ke Zhang, Lai Jiang, Cheng-Lu Jiang, Qiang Cao, Yu-Quan Chen, Hao Chi  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B, Grade B, Grade C, Grade C Novelty: Grade A, Grade B, Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade A, Grade B, Grade C, Grade C  \nScientific Significance: Grade A, Grade B, Grade B, Grade B, Grade B  \nP-Reviewer: Chen ZJ; Li QJ; Tang YX  \nReceived: October 22, 2024  \nRevised: February 16, 2025  \nAccepted: April 14, 2025  \nPublished online: June 15, 2025  \nProcessing time: 235 Days and 4 Hours  \nSheng-Ke Zhang, Lai Jiang, Cheng-Lu Jiang, Hao Chi, Clinical Medical College, Southwest Medical University, Luzhou 646000, Sichuan Province, China  \nQiang Cao, School of Medicine, Macau University of Science and Technology, Macau 999078, China  \nYu-Quan Chen, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria 3004, Australia  \nCorresponding author: Hao Chi, PhD, Assistant Professor, Clinical Medical College, Southwest Medical University, No. 319 Zhongshan Road, Luzhou 646000, Sichuan Province, China.  \n[chihao7511@gmail.com](chihao7511@gmail.com)  \nAbstract  \nTwo landmark studies demonstrate synergistic approaches to gastrointestinal cancer management. Lin et al identified activin A receptor type 1C polymorphisms (rs4556933/rs77886248) as esophageal squamous cell carcinoma risk modifiers in Chinese Han populations through a case-control study (1264 patients/1361 controls), revealing transforming growth factor-beta pathwaymediated susceptibility in older male smokers (P \u003C 0.001) . Concurrently, Luo et al established imaging-based differentiation of pancreatic cancer subtypes (pancreatic ductal adenocarcinoma vs neuroendocrine tumors) via retrospective analysis of 500 cases (area under the curve = 0.89), enabling earlier intervention. These findings underscore the transformative potential of combining genetic risk stratification with advanced imaging to guide precision screening and therapeutic strategies, addressing critical gaps in esophageal and pancreatic cancer outcomes.  \nKey Words: Genetic polymorphisms; Esophageal squamous cell carcinoma; Pancreatic cancer; Imaging markers; Activin A receptor type 1C; Single nucleotide polymorphisms  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 June 15, 2025  Volume 17  Issue 6   \nZhang SK et al. Genetic and imaging advances in oncology  \nCore Tip: This article highlights key advancements in cancer research through the integration of genetic and imaging data. The study by Lin et al identifies activin A receptor type 1C gene polymorphisms as significant risk factors for esophageal squamous cell carcinoma, offering new possibilities for genetic screening and personalized prevention strategies in high-risk populations. Meanwhile, Luo et al’s analysis of imaging features correlated with pancreatic cancer subtypes, such as pancreatic ductal adenocarcinoma and neuroendocrine tumors, enhances diagnostic precision. Together, these studies underscore the importance of combining molecular and imaging tools to refine early detection and optimize treatment approaches in oncology.  \nCitation: Zhang SK, Jiang L, Jiang CL, Cao Q, Chen YQ, Chi H. Unveiling genetic susceptibility in esophageal squa","cbCaieQwzwkXIBUO","https://ap.wps.com/l/cbCaieQwzwkXIBUO","pdf",400184,"English","# Introduction\n## Core Tip","[{\"question\":\"What genetic variant is linked to esophageal squamous cell carcinoma risk in the Lin et al study?\",\"answer\":\"Activin A receptor type 1C polymorphisms (rs4556933/rs77886248) were identified as risk modifiers in Chinese Han populations.\"},{\"question\":\"How does the Luo et al study differentiate pancreatic cancer subtypes?\",\"answer\":\"It uses imaging-based differentiation between pancreatic ductal adenocarcinoma and neuroendocrine tumors, validated by retrospective analysis and reporting an AUC of 0.89.\"},{\"question\":\"Why is combining genetic risk stratification with imaging emphasized?\",\"answer\":\"The document argues this combination enables earlier detection and more personalized screening and therapeutic strategies, improving outcomes where current diagnosis is often late.\"}]","Unveiling genetic susceptibility in esophageal squamous cell carcinoma and revolutionizing pancreatic cancer diagnosis through imaging | PDF",1790192361,15]