[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330560-105":59,"doc-detail-330560-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","unveiling-collagens-role-in-breast-cancer-insights-into-expression-patterns-functions-and-clinical-implications-review","Unveiling Collagen’s Role in Breast Cancer - Insights into Expression Patterns, Functions and Clinical Implications - Review","","Collagen is the predominant extracellular matrix (ECM) protein family, with 28 members, and it extends beyond structural roles into cancer biology. In breast cancer, specific collagens show differential expression between tumor and normal tissues, influencing proliferation, metastasis, apoptosis, and drug resistance. This review evaluates collagen member expression using GEPIA2-derived TPM data, highlighting dysregulated collagens, associated mechanisms, and recent advances. Findings support biomarker and therapeutic target discovery to improve intervention strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unveiling-collagens-role-in-breast-cancer-insights-into-expression-patterns-functions-and-clinical-implications-review/330560/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unveiling-collagens-role-in-breast-cancer-insights-into-expression-patterns-functions-and-clinical-implications-review/330560.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is collagen important in breast cancer progression?","Question",{"text":112,"@type":113},"Collagen influences key cellular processes such as proliferation, metastasis, apoptosis, and drug resistance. It also reshapes the tumor microenvironment through ECM organization and stiffness changes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the review evaluate collagen expression in breast cancer?",{"text":117,"@type":113},"It analyzes individual collagen members using Transcripts Per Million (TPM) data sourced from the GEPIA2 database.",{"name":119,"@type":110,"acceptedAnswer":120},"What do differential collagen expression patterns suggest for diagnosis or treatment?",{"text":121,"@type":113},"Collagens that deviate from normal expression patterns point to specific biological functions and may serve as potential biomarkers and therapeutic targets for more effective breast cancer interventions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330560,1790153460,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","International Journal of General Medicine Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nUnveiling Collagen’s Role in Breast Cancer: Insights into Expression Patterns, Functions and Clinical Implications  \nXia Li 1 , Yue Jin 1 , Jian Xue 2  \n1Department of Molecular Diagnosis, Northern Jiangsu People’s Hospital, Yangzhou, People’s Republic of China; 2Department of Emergency Medicine, Yizheng People’s Hospital, Yangzhou, People’s Republic of China  \nCorrespondence: Yue Jin, Department of Molecular Diagnosis, Northern Jiangsu People’s Hospital, No. 98, Nantong West Road, Yangzhou, Jiangsu Province, People’s Republic of China, [Email yyue_king@163.com](Email yyue_king@163.com)  \n\n| Abstract: Collagen, the predominant protein constituent of the mammalian extracellular matrix (ECM), comprises a diverse family of 28 members (I–XXVIII) . Beyond its structural significance, collagen is implicated in various diseases or cancers, notably breast cancer, where it influences crucial cellular processes including proliferation, metastasis, apoptosis, and drug resistance, intricately shaping cancer progression and prognosis. In breast cancer, distinct collagens exhibit differential expression profiles, with some showing heightened or diminished levels in cancerous tissues or cells compared to normal counterparts, suggesting specific and pivotal biological functions. In this review, we meticulously analyze the expression of individual collagen members in breast cancer, utilizing Transcripts Per Million (TPM) data sourced from the GEPIA2 database. Through this analysis, we identify collagens that deviate from normal expression patterns in breast cancer, providing a comprehensive overview of their expression dynamics, functional roles, and underlying mechanisms. Our findings shed light on recent advancements in understanding the intricate interplay between these aberrantly expressed collagens and breast cancer. This exploration aims to offer valuable insights for the identification of potential biomarkers and therapeutic targets, thereby advancing the prospects of more effective interventions in breast cancer treatment. Keywords: collagen, breast cancer, extracellular matrix, prognostic marker |\n| --- |\n| Introduction\u003Cbr>Breast cancer, characterized by its heterogeneity, has become the leading cause of cancer-related deaths among women worldwide, presenting significant challenges to clinical management due to its high morbidity and mortality rates.1 Despite considerable advancements in breast cancer research, the identification of specific and effective targets remains elusive, rendering the treatment of breast cancer an ongoing challenge. Consequently, there is an urgent need to identify effective diagnostic, prognostic and therapeutic targets.\u003Cbr>Recent advances in the understanding of breast cancer progression implicate key processes such as epithelial– mesenchymal transition (EMT), the presence of cancer stem cells (CSC), and dysregulation of ECM functions. Among these, ECM is crucial for cell proliferation, differentiation, and tissue homeostasis maintenance. Serving asa pivotal component of the tumor microenvironment, it orchestrates complex tissue interactions influencing tumor growth and metastasis. Acting as a substrate for cell adhesion and a reservoir for growth factors, ECM plays indispensable roles in cancer development and metastasis. It is extensively studied in the context of breast cancer due to its disrupted regulation.2\u003Cbr>Within ECM, proteins, glycoproteins, proteoglycans, and polysaccharides collectively contribute, with collagen standing out as the most abundant component.3 Collagen constitutes approximately 30% of mammalian total protein, predominantly found in bone and skin. Apart from its structural role in determining tissue mechanical properties and shape, collagen acts as a physical barrier to cell migration and regulates proliferation in both normal and cancer cel","cbCaivyd7Gb3Tmfb","https://ap.wps.com/l/cbCaivyd7Gb3Tmfb","pdf",1918448,15,"English","# Introduction\n## Collagen within the ECM and breast cancer relevance\n# Methods and data source\n## GEPIA2 TPM analysis of collagen members\n# Results and interpretation\n## Differential expression patterns and biological functions\n# Clinical implications\n## Biomarkers and therapeutic targets","[{\"question\":\"Why is collagen important in breast cancer progression?\",\"answer\":\"Collagen influences key cellular processes such as proliferation, metastasis, apoptosis, and drug resistance. It also reshapes the tumor microenvironment through ECM organization and stiffness changes.\"},{\"question\":\"How does the review evaluate collagen expression in breast cancer?\",\"answer\":\"It analyzes individual collagen members using Transcripts Per Million (TPM) data sourced from the GEPIA2 database.\"},{\"question\":\"What do differential collagen expression patterns suggest for diagnosis or treatment?\",\"answer\":\"Collagens that deviate from normal expression patterns point to specific biological functions and may serve as potential biomarkers and therapeutic targets for more effective breast cancer interventions.\"}]","Unveiling Collagen’s Role in Breast Cancer - Insights into Expression Patterns, Functions and Clinical Implications - Review | PDF",1789989409,38]