[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331418-105":59,"doc-detail-331418-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","unraveling-trpv1s-role-in-cancer-expression-modulation-and-therapeutic-opportunities-with-capsaicin","Unraveling TRPV1’s Role in Cancer - Expression, Modulation, and Therapeutic Opportunities with Capsaicin","","Cancer is a global health challenge with rising incidence and mortality, making mechanism-driven strategies urgent. Cancer pathogenesis disrupts cellular signaling, enabling uncontrolled growth, metastasis, and altered pain and treatment responsiveness. Transient Receptor Potential (TRP) channels, especially TRPV1 (the capsaicin receptor), show altered expression in tumors and participate in tumorigenesis and progression. TRPV1 activation promotes calcium influx, reshapes signaling networks, and influences cancer cell death, cancer-associated pain, chemo-sensitivity, and tumor microenvironment interactions. This review highlights capsaicin–TRPV1–mediated effects across cell types, signaling pathways, and therapeutic opportunities, while outlining limitations.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unraveling-trpv1s-role-in-cancer-expression-modulation-and-therapeutic-opportunities-with-capsaicin/331418/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unraveling-trpv1s-role-in-cancer-expression-modulation-and-therapeutic-opportunities-with-capsaicin/331418.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is TRPV1 and why is it important in cancer biology?","Question",{"text":113,"@type":114},"TRPV1 is the capsaicin receptor, and it is recognized for its altered expression in cancer cells and roles in tumor development and progression, including regulation of cell cycle advancement and programmed cell death.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does TRPV1 activation influence cancer cells?",{"text":118,"@type":114},"Activation of TRPV1 triggers calcium influx and depolarization, affecting cell signaling pathways that control growth and death, and it is linked to cancer-associated pain and treatment responsiveness.",{"name":120,"@type":111,"acceptedAnswer":121},"What therapeutic opportunities does capsaicin offer in relation to TRPV1?",{"text":122,"@type":114},"Capsaicin interacts with TRPV1 to elicit calcium influx and modulate cancer-related processes; the review discusses its potential anti-cancer effects, including impacts on cell proliferation and cancer pain, across multiple tumor contexts.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331418,1790196203,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","molecules   \nReview  \nUnraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin  \nSubramanyam R. Chinreddy, Nicole Tendayi Mashozhera, Badraldeen Rashrash, Gerardo Flores-Iga , Padma Nimmakayala , Gerald R. Hankins, Robert T. Harris and Umesh K. Reddy *  \nCitation: Chinreddy, S.R.;  \nMashozhera, N.T.; Rashrash, B.; Flores-Iga, G.; Nimmakayala, P.; Hankins, G.R.; Harris, R.T.; Reddy, U.K. Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin. Molecules 2024, 29, 4729 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules29194729  \nAcademic Editors: Francesca Aiello and Anna Ramunno  \nReceived: 15 September 2024  \nRevised: 2 October 2024  \nAccepted: 2 October 2024  \nPublished: 7 October 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Biology, West Virginia State University, Institute, WV 25112, USA;  \n[subramanyam.chinreddy@wvstateu.edu](subramanyam.chinreddy@wvstateu.edu) (S.R.C.); [nmashozhera@wvstateu.edu](nmashozhera@wvstateu.edu) (N.T.M.);  \n[brashrash2@wvstateu.edu](brashrash2@wvstateu.edu) (B.R.); [juan.iga@wvstateu.edu](juan.iga@wvstateu.edu) (G.F.-I.); [padma@wvstateu.edu](padma@wvstateu.edu) (P.N.);  \n[ghankins@wvstateu.edu](ghankins@wvstateu.edu) (G.R.H.); [harrisro@wvstateu.edu](harrisro@wvstateu.edu) (R.T.H.)  \n* [Correspondence: ureddy@wvstateu.edu](Correspondence: ureddy@wvstateu.edu)  \nAbstract: Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as a leading cause of death worldwide, contributing to nearly one in six deaths. Cancer pathogenesis involves disruptions in cellular signaling pathways, resulting in uncontrolled cell growth and metastasis. Among emerging players in cancer biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due to their altered expression in cancer cells and roles in tumorigenesis and progression. TRPV1, also known as the capsaicin receptor, is pivotal in cancer cell death and pain mediation, offering promise as a therapeutic target. Activation of TRPV1 triggers calcium influx and affects cell signaling linked to growth and death. Additionally, TRPV1 is implicated in cancer-induced pain and chemo-sensitivity, with upregulation observed in sensory neurons innervating oral cancers. Also, when capsaicin, a compound from chili peppers, interacts with TRPV1, it elicits a “hot” sensation and influences cancer processes through calcium influx. Understanding TRPV1’s multifaceted roles in cancer may lead to novel therapeutic strategies for managing cancer-related symptoms and improving patient outcomes. The current review elucidates the comprehensive role of capsaicin in cancer therapy, particularly through the TRPV1 channel, highlighting its effects in various cells via different signaling pathways and discussing its limitations.  \nKeywords: TRPV1; cancer pain; signaling pathways; cancer therapy; capsaicin  \n1. Introduction  \nCancer continues to be a major cause of death globally, with both its occurrence and death rates projected to increase in the coming years. In 2023, 10 million deaths were attributed to cancer, highlighting the urgent need to develop strategies to fully understand its mechanisms, enable early detection, and create more effective treatments [1–3] . The pathogenesis of cancer involves a complex interplay of genetic and epigenetic changes that interfere with cellular signaling pathways, including oncogenes, tumor-suppressor genes, and defects in DNA repair mechanisms, all of whi","cbCaipgk0L5P3HMs","https://ap.wps.com/l/cbCaipgk0L5P3HMs","pdf",1350973,15,"English","# Introduction\n## Cancer burden and mechanistic drivers\n## TRP/TRPV1 involvement in cancer signaling\n## TRPV1 interactions with PI3K/AKT and MAPK pathways\n## TRPV1 and tumor microenvironment/immune modulation\n## Capsaicin as a TRPV1 agonist in cancer contexts","[{\"question\":\"What is TRPV1 and why is it important in cancer biology?\",\"answer\":\"TRPV1 is the capsaicin receptor, and it is recognized for its altered expression in cancer cells and roles in tumor development and progression, including regulation of cell cycle advancement and programmed cell death.\"},{\"question\":\"How does TRPV1 activation influence cancer cells?\",\"answer\":\"Activation of TRPV1 triggers calcium influx and depolarization, affecting cell signaling pathways that control growth and death, and it is linked to cancer-associated pain and treatment responsiveness.\"},{\"question\":\"What therapeutic opportunities does capsaicin offer in relation to TRPV1?\",\"answer\":\"Capsaicin interacts with TRPV1 to elicit calcium influx and modulate cancer-related processes; the review discusses its potential anti-cancer effects, including impacts on cell proliferation and cancer pain, across multiple tumor contexts.\"}]","Unraveling TRPV1’s Role in Cancer - Expression, Modulation, and Therapeutic Opportunities with Capsaicin | PDF",1789993190,38]