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This systematic review evaluates the association between WMH and migraine, examining prevalence, progression, and links with clinical and demographic characteristics. Observational studies published from 1990 to May 2025 were screened and extracted by two independent reviewers, with quality assessed using the Newcastle-Ottawa scale.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unraveling-the-relationship-between-white-matter-lesions-in-mri-and-migraine-a-systematic-review/438599/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unraveling-the-relationship-between-white-matter-lesions-in-mri-and-migraine-a-systematic-review/438599.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What issue does the review address regarding MRI findings in migraine?","Question",{"text":112,"@type":113},"The review addresses uncertainty about the clinical relevance and mechanisms of white matter hyperintensities (WMH) detected on MRI in migraine patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the systematic review conducted?",{"text":117,"@type":113},"It included observational studies from 1990 to May 2025 with adult migraine patients who underwent brain MRI (at least 1.5T). Two independent reviewers extracted data, with disagreements resolved by a third, and study quality was assessed using the Newcastle-Ottawa scale.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the review find about WMH and migraine characteristics?",{"text":121,"@type":113},"WMHs were often observed in migraine patients, especially those with aura, longer disease duration, and higher headache frequency. No consistent association was found between WMH and comorbidities, and heterogeneity across studies limited comparability and meta-analysis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},438599,1791022675,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Article published online: 2025-12-22  \nOriginal Article 1  \nUnraveling the relationship between white matter lesions in MRI and migraine: a systematic review  \nVerena Subtil Viuniski 1 Matheus de Lima Ruffini1 Adolfo Moraes de Souza 1  \nRaquel Prates dos Santos 1 Davi Henrique Galvao Fonseca Ribeiro 1 Leandro Lisboa Faoro 1 Fabiano Reis2 Renata Gomes Londero 1 Juliana Avila Duarte 1  \n1 Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de Medicina Interna, Porto Alegre RS, Brazil.  \n2 Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Disciplina de Medicina Interna e Semiologia, Campinas SP, Brazil.  \nArq. Neuro-Psiquiatr. 2025;83(11):s00451812886 .  \nAddress for correspondence Juliana Ávila Duarte (email: [juduarte@hcpa.edu.br](juduarte@hcpa.edu.br))  \nAbstract  \nKeywords  \n► Migraine Disorders  \n► Magnetic Resonance Imaging  \n► White Matter  \n► Neuroimaging  \nBackground White matter hyperintensities (WMH) are commonly detected on brain magnetic resonance imaging (MRI) scans of migraine patients, but their clinical relevance and underlying mechanisms remain uncertain.  \nObjective To systematically review the relationship between WMH and migraine, focusing on prevalence, progression, and associations with clinical and demographic characteristics.  \nMethods We conducted a systematic review of observational studies published between 1990 and May 2025, including adult patients with migraine (with or without aura) who underwent brain MRIs with at least 1 .5T scanners. Data extraction was performed by two independent reviewers, with disagreements resolved by a third. Study quality was assessed using the Newcastle-Ottawa scale for observational studies. Results A total of 25 studies were included, comprising approximately 3,600 participants, of whom 1,725 had migraine. Most participants were women and reported age means or medians typically between 30 and 60 years. Frequently, WMHs were observed in migraine patients, particularly in those with aura, longer disease duration, and higher headache frequency. No consistent association was found between WMH and comorbidities. Significant heterogeneity in imaging protocols, lesion quantification methods, and study design limited data comparability and precluded meta-analysis.  \nConclusion Migraine patients often present with WMHs, but their clinical significance remains unclear. Future studies should employ standardized MRI protocols, volumetric lesion quantification, and consistent migraine phenotyping to clarify its pathophysiological role in migraine and potential implications for diagnosis and management.  \nreceived  \nDecember 9, 2024 received in its final form  \nAugust 4, 2025  \naccepted  \nSeptember 9, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1812886 . ISSN 0004-282X.  \nEditor-in-Chief: Hélio A. G. Teive.  \nAssociate Editor: Pedro André Kowacs.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \nWhite matter lesions in MRI and migraine: systematic review Viuniski et al.  \nINTRODUCTION  \nAs fairly common as migraine can be in the general population, so are the challenges it proposes to the clinical practitioner and referred neurologist.1 The imaging diagnostic tools are ever improving, and it is tempting to address a disease through them, especially in areas where misdiagnosis can lead to permanent impairment.  \nUsually, when there is clinical evidence of migraine, as stated by the International Classification of Headache Disorders 3rd edition (ICHD-3),2 and no new featu","cbCaifs8n1Rn7ZRr","https://ap.wps.com/l/cbCaifs8n1Rn7ZRr","pdf",499915,13,"English","# Abstract\n# Background\n# Objective\n# Methods\n## Study selection and quality assessment\n# Results\n# Conclusion\n# Introduction\n# Methods","[{\"question\":\"What issue does the review address regarding MRI findings in migraine?\",\"answer\":\"The review addresses uncertainty about the clinical relevance and mechanisms of white matter hyperintensities (WMH) detected on MRI in migraine patients.\"},{\"question\":\"How was the systematic review conducted?\",\"answer\":\"It included observational studies from 1990 to May 2025 with adult migraine patients who underwent brain MRI (at least 1.5T). Two independent reviewers extracted data, with disagreements resolved by a third, and study quality was assessed using the Newcastle-Ottawa scale.\"},{\"question\":\"What did the review find about WMH and migraine characteristics?\",\"answer\":\"WMHs were often observed in migraine patients, especially those with aura, longer disease duration, and higher headache frequency. No consistent association was found between WMH and comorbidities, and heterogeneity across studies limited comparability and meta-analysis.\"}]","Unraveling the relationship between white matter lesions in MRI and migraine - a systematic review | PDF",1790685833,33]