[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-344707-105":59,"doc-detail-344707-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","unraveling-the-microbial-landscape-in-prostate-cancer-pathogenesis-to-therapy","Unraveling the microbial landscape in prostate cancer: pathogenesis to therapy","","Emerging evidence links dysregulated microbiota to prostate cancer, yet the causal basis and molecular mechanisms remain insufficiently resolved. This review surveys microbes from the skin, oral cavity, gut, urinary tract, and the prostate cancer microenvironment to clarify how these communities influence initiation, progression, and therapeutic responses. It emphasizes host–microbiota pathways, metabolic reprogramming, epigenetic reset, and chronic inflammation, while detailing major investigative challenges and knowledge gaps guiding microbiome-based therapy strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unraveling-the-microbial-landscape-in-prostate-cancer-pathogenesis-to-therapy/344707/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unraveling-the-microbial-landscape-in-prostate-cancer-pathogenesis-to-therapy/344707.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does the microbiome relate to prostate cancer initiation and progression?","Question",{"text":112,"@type":113},"The review summarizes evidence that dysregulated microbiomes can modulate tumor initiation and progression through mechanisms such as drug metabolism dysfunction, altered signaling pathways, epigenetic changes, chronic inflammation, and microenvironment reprogramming.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is identifying prostate cancer–associated microbial signatures difficult?",{"text":117,"@type":113},"Research is hindered by issues including sample contamination and imprecise sequence alignment, which can obscure true cancer-resident signals and compromise computational robustness.",{"name":119,"@type":110,"acceptedAnswer":120},"What methods are commonly used to characterize tumor-associated microbiomes in prostate cancer?",{"text":121,"@type":113},"The review highlights 16S rRNA gene sequencing and metagenomic sequencing as the principal approaches, noting that prostate typically has fewer resident microbiomes than many other organs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},344707,1790182240,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","npj | biofilms and microbiomes Review  \nPublished in partnership with Nanyang Technological University  \n[https://doi.org/10.1038/s41522-025-00900-w](https://doi.org/10.1038/s41522-025-00900-w)  \nUnraveling the microbial landscape in prostate cancer: pathogenesis to therapy  \n Check for updates  \n\n| Xiancai Du1, Jing Wu1, Siyuan Xia1 , Hao Zheng2  & Baotong Zhang1  |  |\n| --- | --- |\n| Emerging evidence suggests a role of microbiota in prostate cancer, yet this association remains poorly understood. This review systematically examines microbes from the skin, oral cavity, gut, urinary tract, and the prostate cancer microenvironment, summarizing how these communities affect prostate cancer initiation, progression, and therapeutic response. We highlight key molecular pathways and metabolic reprogramming events underlying host-microbiota interactions and outline current findings and knowledge gaps to guide microorganism-based therapeutic strategies. |  |\n| Prostate cancer(PCa) is the second most common malignancy among men worldwide and its mortality rate is projected to more than double over the next decade1. Early-stage localized prostate cancer is associated with favorable survival and prognosis when treated with antiandrogen therapies. However, prolonged use of these therapies often leads to the progression of PCa into castration-resistant prostate cancer (CRPC), a treatment-resistant state that is more prone to metastasis2–4. Metastatic castration-resistant prostate cancer (mCRPC) is the advanced stage of PCa, and recurrence and therapeutic resistance remain significant challenges for the management of mCRPC5,6.\u003Cbr>The microbiome is composed of bacteria, fungi, archaea and viruses that live in symbiosis with their hosts. A growing body of evidence indicates that dysregulated microbiome can modulate tumor initiation and progression7,8. With the rapid development of DNA and RNA sequencing technologies, the microbiome in host has been well discovered9, 10. By implementing gold-standard contamination control measures and addressing the challenge of low microbial abundance, research on tumorassociated microbiomes has progressed from descriptive analyses to indepth investigations of causal relationships and underlying molecular mechanisms11–13. Emerging evidence suggests that the microbiome affects tumor progression mainly through dysfunction of drug metabolism, dysregulation of tumor-associated signaling pathways, resetting of epigenetic modifications, induction of chronic inflammation, and reprograming of microenvironment7, 14–18. These findings highlight the critical role of the microbiome asan external factor in tumorbiology, complementing intrinsic tumor characteristics.\u003Cbr>However, due to its anatomical location, the prostate lacks the rich commensal microbiome found in the gastrointestinal tract, leading to a limited understanding of microbial signatures associated with PCa19,20. Whether and how the microbiome affects PCa progression remain underinvestigated21. A deeper understanding of the specific features and mechanistic roles of the microbiome in PCa is essential for advancing | personalized and precision oncology22. Here, we will provide a comprehensive overview ofthe challenges in investigating the role ofthe microbiota in PCa, highlighting how microbiota from different organs can modulate disease progression and the strategies they employ in regulating tumor development. This in-depth analysis aims to establish a foundational microbial framework to inform both monotherapy and combination strategies targeting the PCa microbiome.\u003Cbr>Challenges in investigating the role of the microbiota in prostate cancer\u003Cbr>Analyses of extensive publicly available whole-genome and wholetranscriptome sequencing datasets have identified a variety of tumorassociated microbiomes, laying the groundwork for the initial characterization of microbial communities23–25. However, despite the use of various contamination control strategies, efforts to ide","cbCaikHnv5CHvMXf","https://ap.wps.com/l/cbCaikHnv5CHvMXf","pdf",1808505,17,"English","# Emerging role of the microbiome in prostate cancer\n# Challenges in investigating microbiota in prostate cancer\n## Contamination control and sequence-alignment limitations\n## Key sequencing methods and tissue-specific constraints","[{\"question\":\"How does the microbiome relate to prostate cancer initiation and progression?\",\"answer\":\"The review summarizes evidence that dysregulated microbiomes can modulate tumor initiation and progression through mechanisms such as drug metabolism dysfunction, altered signaling pathways, epigenetic changes, chronic inflammation, and microenvironment reprogramming.\"},{\"question\":\"Why is identifying prostate cancer–associated microbial signatures difficult?\",\"answer\":\"Research is hindered by issues including sample contamination and imprecise sequence alignment, which can obscure true cancer-resident signals and compromise computational robustness.\"},{\"question\":\"What methods are commonly used to characterize tumor-associated microbiomes in prostate cancer?\",\"answer\":\"The review highlights 16S rRNA gene sequencing and metagenomic sequencing as the principal approaches, noting that prostate typically has fewer resident microbiomes than many other organs.\"}]","Unraveling the microbial landscape in prostate cancer: pathogenesis to therapy | PDF",1790055006,43]