[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338709-105":59,"doc-detail-338709-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","unraveling-molecular-interconnections-and-identifying-potential-therapeutic-targets-of-significance-in-obesity-cancer-link-overview-and-future-directions","Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link - Overview and future directions","","Obesity, a global health concern, is associated with severe comorbidities and elevated risk of multiple cancers, including melanoma and breast, prostate, colorectal, renal, and endometrial malignancies. The review links obesity-driven cellular alterations—such as impaired CD8+ T cell function, dyslipidemia, insulin resistance, and fluctuating leptin, resistin, adiponectin, and IL-6—to inflammation and formation of a tumor-promoting microenvironment rich in adipocytes. It highlights adipocyte-derived leptin effects on proliferation and invasion, and the downregulation of adiponectin’s anti-proliferative, pro-apoptotic, and antiangiogenic roles, summarizing emerging molecular connections, therapeutic intervention ideas, and research directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unraveling-molecular-interconnections-and-identifying-potential-therapeutic-targets-of-significance-in-obesity-cancer-link-overview-and-future-directions/338709/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unraveling-molecular-interconnections-and-identifying-potential-therapeutic-targets-of-significance-in-obesity-cancer-link-overview-and-future-directions/338709.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does obesity increase cancer risk according to this review?","Question",{"text":112,"@type":113},"It contributes through obesity-induced cellular and metabolic changes that promote inflammation and create a tumor-promoting microenvironment enriched in adipocytes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do leptin and adiponectin play in the obesity-cancer link?",{"text":117,"@type":113},"Leptin is pro-inflammatory and stimulates cancer cell proliferation, invasion, and inflammation. Adiponectin is typically downregulated in obesity and has anti-proliferative, pro-apoptotic, and antiangiogenic properties.",{"name":119,"@type":110,"acceptedAnswer":120},"What type of review is provided and how are findings synthesized?",{"text":121,"@type":113},"The document is a narrative review using an extensive but non-systematic survey of recent literature, integrating findings to outline emerging themes and potential therapeutic targets.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338709,1790068867,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Journal of the National Cancer Center 5 (2025) 8–27  \nContents lists available at ScienceDirect  \nJournal of the National Cancer Center  \njournal [homepage:](homepage: www.elsevier.com/locate/jncc)[ www.elsevier.com/locate/jncc](homepage: www.elsevier.com/locate/jncc)  \n| Review |  |  |  |\n| --- | --- | --- | --- |\n| Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link |  |  | |\n| Alanoud Abdulla1, Hana Q. Sadida 1, Jayakumar Jerobin2, Imadeldin Elfaki3, Rashid Mir 4, Sameer Mirza5, Mayank Singh 6, Muzafar A. Macha 7, Shahab Uddin8,9, Khalid Fakhro 10,11,12, Ajaz A. Bhat 1,∗, Ammira S. Al-Shabeeb Akil 1,∗\u003Cbr>1 Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Research Program, Sidra Medicine, Doha, Qatar\u003Cbr>2 Qatar Metabolic Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar\u003Cbr>3 Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia\u003Cbr>4 Department of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia\u003Cbr>5 Department of Chemistry, College of Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates\u003Cbr>6 Department of Medical Oncology (Lab.), Dr. BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India\u003Cbr>7 Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Pulwama, Jammu and Kashmir, India\u003Cbr>8 Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar\u003Cbr>9 Laboratory of Animal Research Center, Qatar University, Doha, Qatar\u003Cbr>10 Department of Human Genetics, Sidra Medicine, Doha, Qatar\u003Cbr>11 College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar\u003Cbr>12 Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar |  |  |  |\n| a r t i c l e i n f o |  | a b s t r a c t |  |\n| Keywords: Obesity Cancer risk\u003Cbr>Tumor microenvironment Inflammation Therapeutic interventions Gut microbiome |  | Obesity, a global health concern, is associated with severe health issues like type 2 diabetes, heart disease, and respiratory complications. It also increases the risk of various cancers, including melanoma, endometrial, prostate, pancreatic, esophageal adenocarcinoma, colorectal carcinoma, renal adenocarcinoma, and pre-and postmenopausal breast cancer. Obesity-induced cellular changes, such as impaired CD8+ T cell function, dyslipidemia, hypercholesterolemia, insulin resistance, mild hyperglycemia, and fluctuating levels of leptin, resistin, adiponectin, and IL-6, contribute to cancer development by promoting inflammation and creating a tumorpromoting microenvironment rich in adipocytes. Adipocytes release leptin, a pro-inflammatory substance that stimulates cancer cell proliferation, inflammation, and invasion, altering the tumor cell metabolic pathway. Adiponectin, an insulin-sensitizing adipokine, is typically downregulated in obese individuals. It has antiproliferative, proapoptotic, and antiangiogenic properties, making it a potential cancer treatment. This narrative review offers a comprehensive examination of the molecular interconnections between obesity and cancer, drawing on an extensive, though non-systematic, survey of the recent literature. This approach allows us to integrate and synthesize findings from various studies, offering a cohesive perspective on emerging themes and potential therapeutic targets. The review explores the metabolic disturbances, cellular alterations, inflammatory responses, and shifts in the tumor microenvironment that contribute to the obesity-cancer link. Finally, it discusses potential therapeutic strategies aimed at disrupting these connections, offering valuable insights into future research directions and the development of targeted interventions. |  |\n\n1. Introduction  \nObesity is a growing global epidemic","cbCaic9u8APbcHoR","https://ap.wps.com/l/cbCaic9u8APbcHoR","pdf",3046152,"English","# Introduction\n# Obesity-related metabolic and cellular alterations\n## Inflammation and adipokine signaling\n## Effects on tumor microenvironment\n# Potential therapeutic targets and intervention strategies\n# Future research directions","[{\"question\":\"How does obesity increase cancer risk according to this review?\",\"answer\":\"It contributes through obesity-induced cellular and metabolic changes that promote inflammation and create a tumor-promoting microenvironment enriched in adipocytes.\"},{\"question\":\"What roles do leptin and adiponectin play in the obesity-cancer link?\",\"answer\":\"Leptin is pro-inflammatory and stimulates cancer cell proliferation, invasion, and inflammation. Adiponectin is typically downregulated in obesity and has anti-proliferative, pro-apoptotic, and antiangiogenic properties.\"},{\"question\":\"What type of review is provided and how are findings synthesized?\",\"answer\":\"The document is a narrative review using an extensive but non-systematic survey of recent literature, integrating findings to outline emerging themes and potential therapeutic targets.\"}]","Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link - Overview and future directions | PDF",1790025189]