[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342582-105":59,"doc-detail-342582-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","unraveling-emerging-anal-cancer-clinical-biomarkers-from-current-immuno-oncogenomics-advances","Unraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno-Oncogenomics Advances","","Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy strongly linked to high-risk human papillomavirus (HPV), with rising incidence and mortality in developed countries. While next-generation sequencing has transformed cancer immuno-genomics, limited clinical research has examined how genomic expression and function relate to ASCC. This review consolidates recent “omics” genome-based studies to identify ASCC driver gene expression, signaling pathways, progression biomarkers, diagnostic candidates, therapeutic targets, and emerging treatment opportunities. The work emphasizes urgent development of target-specific precision therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unraveling-emerging-anal-cancer-clinical-biomarkers-from-current-immuno-oncogenomics-advances/342582/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unraveling-emerging-anal-cancer-clinical-biomarkers-from-current-immuno-oncogenomics-advances/342582.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is anal squamous cell carcinoma (ASCC) clinically important?","Question",{"text":112,"@type":113},"ASCC is rare but associated with high-risk HPV and has been among the fastest-growing causes of cancer incidence and mortality in developed countries.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What limitations exist in current clinical research for ASCC?",{"text":117,"@type":113},"Despite advances in next-generation sequencing, relatively few clinical studies have investigated the expression and functional characterization of genomic data specifically in ASCC.",{"name":119,"@type":110,"acceptedAnswer":120},"How does this review support precision medicine in anal cancer?",{"text":121,"@type":113},"By systematically assessing recent omics research, it identifies driver gene expression, progression biomarkers, diagnostic candidates, and therapeutic drug targets, highlighting opportunities for target-specific therapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342582,1790098963,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Molecular Diagnosis & Therapy (2024) 28:201–214 [https://doi.org/10.1007/s40291-023-00692-9](https://doi.org/10.1007/s40291-023-00692-9)  \nUnraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno‑Oncogenomics Advances  \nSoledad Iseas1 · Golubicki Mariano2 · Louis Gros1 · Nabil Baba‑Hamed1 · Vincent De Parades3 · Julien Adam4 · Eric Raymond1 · Martin Carlos Abba5  \nAccepted: 26 December 2023 / Published online: 24 January 2024 © The Author(s) 2024  \nAbstract  \nAnal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk human papillomavirus (HPV) and is currently one of the fastest-growing causes of cancer incidence and mortality in developed countries. Although next-generation sequencing technologies (NGS) have revolutionized cancer and immuno-genomic research in various tumor types, a limited amount of clinical research has been developed to investigate the expression and the functional characterization of genomic data in ASCC. Herein, we comprehensively assess recent advancements in “omics” research, including a systematic analysis of genome-based studies, aiming to identify the most relevant ASCC cancer driver gene expressions and their associated signaling pathways. We also highlight the most significant biomarkers associated with anal cancer progression, gene expression of potential diagnostic biomarkers, expression of therapeutic drug targets, and emerging treatment opportunities. This review stresses the urgent need for developing target-specific therapies in ASCC. By illuminating the molecular characteristics and drug-target expression in ASCC, this study aims to provide insights for the development of precision medicine in anal cancer.  \n1 Introduction  \nAnal squamous cell carcinoma (ASCC) is a rare cancer, accounting for less than 3% of all gastrointestinal neoplasms and less than 1% of all worldwide cancers in both men and women [1] . Worldwide, ASCC is one of the fastest accelerating causes of cancer incidence and mortality in developed  \nExtended author information available on the last page of the article  \ncountries, particularly in North America and Western Europe [2, 3] . In the USA, 8590 new cases in women and 3350 new cases in men were estimated in 2021. According to the European Cancer Information System (ECIS), there were an estimated 16,600 new cases and 7300 deaths in 2020 [4]. Usually, the average age at diagnosis is around 62 years. However, there has also been an increase in the incidence of anal cancer among younger adults. The age-standardized incidence rate of anal cancer has increased from 0.7 to 1.2 cases per 100,000 populations in 2018, particularly among those aged 20–49 years [5] . The reason for the increase in anal cancer incidence is correlated to an increase in the burden numbers of human papillomavirus (HPV)-related cancers. Other well-known risk factors associated with ASCCare HIV infection, tobacco smoking, immunosuppression following transplantation, and autoimmune diseases such as Crohn’s disease [5, 6] .  \nThere are rising levels of awareness over the last few years regarding the prevention of HPV related cancer via vaccination programs and the importance of screening based on an annual systematic Pap test or HPV screening detection, which has been recommended for high-risk groups [7, 8] . Unfortunately, treatment options for non-metastatic ASCC (NM-ASCC) have not evolved significantly over the last 2 decades; concurrent chemoradiotherapy remains the  \nstandard of care strategy for non-metastatic diseases. A combination of chemoradiotherapy has yielded a high rate of complete local regression and stands as an efficient strategy allowing anal-surgery preservation and sparing anal functions [8] . Nevertheless, 5-year disease-free survival (DFS) rates in NM-ASCC remain very heterogeneous, ranging from 85% in early tumors to 35% ASCC with lymph node invasion [6, 9, 10]. In clinical practice, prognostic factors of survival in ASCC are ","cbCaiiqbD3AdKqKI","https://ap.wps.com/l/cbCaiiqbD3AdKqKI","pdf",1444099,14,"English","# Abstract\n# 1 Introduction\n# 2 Genomic Changes in ASCC Development and Progression","[{\"question\":\"Why is anal squamous cell carcinoma (ASCC) clinically important?\",\"answer\":\"ASCC is rare but associated with high-risk HPV and has been among the fastest-growing causes of cancer incidence and mortality in developed countries.\"},{\"question\":\"What limitations exist in current clinical research for ASCC?\",\"answer\":\"Despite advances in next-generation sequencing, relatively few clinical studies have investigated the expression and functional characterization of genomic data specifically in ASCC.\"},{\"question\":\"How does this review support precision medicine in anal cancer?\",\"answer\":\"By systematically assessing recent omics research, it identifies driver gene expression, progression biomarkers, diagnostic candidates, and therapeutic drug targets, highlighting opportunities for target-specific therapies.\"}]","Unraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno-Oncogenomics Advances | PDF",1790047255,35]