[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331255-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-331255-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","unraveling-cancer-progression-pathways-and-phytochemical-therapeutic-strategies-for-its-management-review","Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management - Review","","Cancer prevention is framed as a molecular-based strategy to block carcinogenesis at pre-cancerous stages such as dysplasia and carcinoma in situ. The review analyzes cancer progression pathways, emphasizing NF-κB, Wnt/β-catenin, JAK-STAT, TNF-α-mediated, and MAPK/mTOR signaling, alongside apoptotic and angiogenic mechanisms. Molecular evaluation of effector molecules addressed through phytomolecules is used to explain how these pathways intersect cancer formation and metastasis. Plant-derived secondary metabolites are surveyed for anticancer potential, including eugenol, anethole, capsaicin, sanguinarine, EGCG, 6-gingerol, and resveratrol, with attention to chronic toxicity profiling.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/unraveling-cancer-progression-pathways-and-phytochemical-therapeutic-strategies-for-its-management-review/331255/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/unraveling-cancer-progression-pathways-and-phytochemical-therapeutic-strategies-for-its-management-review/331255.png","ImageObject",300,407,{"name":42,"@type":43},"Theodore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the review emphasize about cancer prevention stages?","Question",{"text":63,"@type":64},"It positions cancer prevention as a molecular-based approach targeting pre-cancerous stages such as dysplasia and carcinoma in situ.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which major signaling pathways are discussed in cancer progression?",{"text":68,"@type":64},"NF-κB, Wnt/β-catenin, JAK-STAT, TNF-α-mediated, and MAPK/mTOR pathways are highlighted, along with apoptotic and angiogenic pathways.",{"name":70,"@type":61,"acceptedAnswer":71},"How are phytochemicals used in managing cancer progression?",{"text":72,"@type":64},"The review discusses phytomolecules and plant secondary metabolites that modulate key effector molecules, aiming to inhibit tumor growth, spread, and progression from in situ to invasive cancer, while also considering chronic toxicity profiling.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331255,1790541480,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","TYPE Review  \nPUBLISHED 23 August 2024  \nDOI 10.3389/fphar.2024.1414790  \nOPEN ACCESS  \nEDITED BY  \nBasel A. Abdel-Wahab,  \nNajran University, Saudi Arabia  \nREVIEWED BY  \nRuo Wang,  \nShanghai Jiao Tong University, China Ranjith Kumar Kankala,  \nHuaqiao University, China  \n*CORRESPONDENCE  \nSandeep Kumar,  \n [ph.sandeep@gmail.com](ph.sandeep@gmail.com)[ ](ph.sandeep@gmail.com)Sanjay Kumar,  \n [Sanjay.kumar7@sharda.ac.in](Sanjay.kumar7@sharda.ac.in)  \n†These authors contributed equally and shared first authorship  \nRECEIVED 09 April 2024  \nACCEPTED 09 May 2024  \nPUBLISHED 23 August 2024  \nCITATION  \nSharma V, Chaudhary AA, Bawari S, Gupta S, Mishra R, Khan S-U-D, Ali MAM, Shahid M, Srivastava S, Verma D, Gupta A, Kumar S and Kumar S (2024), Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management.  \nFront. Pharmacol. 15:1414790 .  \ndoi: 10.3389/fphar.2024.1414790  \nCOPYRIGHT  \n© 2024 Sharma, Chaudhary, Bawari, Gupta, Mishra, Khan, Ali, Shahid, Srivastava, Verma, Gupta, Kumar and Kumar. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nUnraveling cancer progression pathways and phytochemical therapeutic strategies for its management  \nVikas Sharma 1,2†, Anis Ahmad Chaudhary 3†, Sweta Bawari 4, Saurabh Gupta 5, Richa Mishra 6, Salah-Ud-Din Khan 7, Mohamed A. M. Ali 8,9, Mohammad Shahid 10, Saurabh Srivastava 11, Devvrat Verma 12, Arti Gupta 13, Sanjay Kumar 14* and  \nSandeep Kumar 2,15*  \n1Metro College of Health Sciences and Research, Greater Noida, India, 2School of Pharmacy, Sharda University, Greater Noida, India, 3Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia, 4Amity Institute of Pharmacy, Amity University, Noida, India, 5Department of Biotechnology, GLA University, Mathura, India, 6Department of Computer Engineering, Parul University, Vadodara, India, 7Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University(IMSIU), Riyadh, Saudi Arabia, 8Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia, 9Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt, 10Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia, 11School of Pharmacy, KPJ Healthcare University, Nilai, Malaysia, 12Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, India, 13Lloyd School of Pharmacy, Greater Noida, India, 14Biological and Bio-computational Laboratory, Department of Life Science, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida, India, 15DST-FIST Laboratory, Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, India  \nCancer prevention is currently envisioned as a molecular-based approach to prevent carcinogenesis in pre-cancerous stages, i. e., dysplasia and carcinoma in situ. Cancer is the second-leading cause of mortality worldwide, and a more than 61% increase is expected by 2040 . A detailed exploration of cancer progression pathways, including the NF-kβ signaling pathway, Wnt-B catenin signaling pathway, JAK-STAT pathway, TNF-α-mediated pathway, MAPK/mTOR pathway, andapoptotic and angiogenic pathways and effector molecules involved in cancer development, has been discussed in the manuscript. Critical evaluation of these effector molecules through molecular approaches using phytomolecules can intersect cancer formation and its metastasis. Manipulation","cbCaik4hdxnRohWm","https://ap.wps.com/l/cbCaik4hdxnRohWm","pdf",4414810,22,"English","# Highlights\n## Molecular investigation of pre-cancerous lesion development\n## Modulation of effector molecules to disrupt progression\n## Phytochemicals impair signaling and inhibit in situ cancer\n# 1 Introduction\n## Cancer as a leading global cause of death\n## Risk factors driving worldwide cancer burden","[{\"question\":\"What does the review emphasize about cancer prevention stages?\",\"answer\":\"It positions cancer prevention as a molecular-based approach targeting pre-cancerous stages such as dysplasia and carcinoma in situ.\"},{\"question\":\"Which major signaling pathways are discussed in cancer progression?\",\"answer\":\"NF-κB, Wnt/β-catenin, JAK-STAT, TNF-α-mediated, and MAPK/mTOR pathways are highlighted, along with apoptotic and angiogenic pathways.\"},{\"question\":\"How are phytochemicals used in managing cancer progression?\",\"answer\":\"The review discusses phytomolecules and plant secondary metabolites that modulate key effector molecules, aiming to inhibit tumor growth, spread, and progression from in situ to invasive cancer, while also considering chronic toxicity profiling.\"}]","Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management - Review | PDF",1789992435,55]