[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370817-105":59,"doc-detail-370817-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","unmasking-hidden-metastasis-a-case-report-of-gastrointestinal-metastasis-detected-a-decade-after-breast-cancer-diagnosis","Unmasking hidden metastasis - A case report of gastrointestinal metastasis detected a decade after breast cancer diagnosis","","Breast cancer remains a common malignancy in women, and metastasis strongly affects survival and quality of life. Although many patients experience long recurrence-free intervals after surgery and adjuvant therapy, occult metastasis can still emerge, even at late stages. Gastrointestinal involvement is rare and frequently missed, despite evidence that late occult disease may develop after long disease-free periods. This case report describes a 49-year-old woman whose initial presentation included constipation and weight loss, leading to detection of gastric and rectal metastases from breast cancer.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unmasking-hidden-metastasis-a-case-report-of-gastrointestinal-metastasis-detected-a-decade-after-breast-cancer-diagnosis/370817/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unmasking-hidden-metastasis-a-case-report-of-gastrointestinal-metastasis-detected-a-decade-after-breast-cancer-diagnosis/370817.png","ImageObject",300,407,{"name":92,"@type":93},"Mabel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"How were the gastrointestinal metastases diagnosed?","Question",{"text":112,"@type":113},"Computed tomography showed gastric and rectal thickening, and colonoscopy with biopsy demonstrated metastatic tumors originating from breast cancer based on pathological evaluation.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},370817,1790646580,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":52},7971474920318,"https://ap-avatar.wpscdn.com/avatar/74000ee537e6b0ca360?x-image-process=image/resize,m_fixed,w_180,h_180&k=1788430171632181674","®  \n Clinical Case Report   \nUnmasking hidden metastasis  \nA case report of gastrointestinal metastasis detected a decade after breast cancer diagnosis  \nJie Peng, MDa , Ye Liu, MDa , Yiheng Zhang, MDa , Haiyuan Yang, MDa , Guoxin Sun, DDa , Lichao Zhu, MDa , Yating Zhao, DDa ,*  \n\n| Abstract\u003Cbr>Rationale: Breast cancer is among the most common malignancies in women, and metastasis significantly impacts survival and quality of life. Although many patients remain disease-free in the early years after surgery and adjuvant therapy, occult metastasis remains a major clinical concern. While bone, lung, and liver are common metastatic sites, gastrointestinal involvement is rare and often overlooked. Recent evidence suggests that late-stage occult metastasis can develop even after long disease-free intervals. Early detection is vital for optimizing treatment and improving prognosis. Therefore, gastrointestinal symptoms such as abdominal pain, altered bowel habits, or unexplained weight loss in breast cancer patients warrant prompt imaging and endoscopic evaluation.\u003Cbr>Patient concerns: This case report describes a 49-year-old woman with invasive lobular breast carcinoma who, after nearly 11 years of recurrence-free survival, presented with constipation and weight loss. Imaging and endoscopy revealed gastric and rectal metastases, underscoring the risk of occult metastasis in breast cancer. This case highlights the importance of considering age and treatment history when developing personalized management strategies and emphasizes early detection and intervention to improve outcomes and quality of life.\u003Cbr>Diagnoses: Computed tomography revealed thickening of the gastric antrum and rectal wall, resulting in luminal narrowing. A comprehensive flexible colonoscopy was performed, and biopsy of the colonic tissue for pathological examination indicated metastatic tumors in the rectal mucosa originating from breast cancer as well as metastatic lobular carcinoma in the stomach. Interventions: The patient is currently receiving a chemotherapy regimen of gemcitabine 1.4 g and carboplatin (500 mg) . Outcomes: The patient is currently in the chemotherapy phase, and close monitoring of the condition is being conducted during treatment.\u003Cbr>Lessons: For patients with a history of breast cancer, the emergence of new gastrointestinal symptoms or a diagnosis of primary gastric or colorectal cancer should raise suspicion metastatic breast cancer. During the biopsy process, a comprehensive evaluation of histopathological and immunohistochemical analyses is necessary, and these results should be compared with those of primary breast cancer to ensure an accurate diagnosis.\u003Cbr>Abbreviations: CT = computed tomography, ILC = invasive lobular carcinoma. |\n| --- |\n| Keywords: breast cancer, breast surgery, gastrointestinal metastasis of breast cancer |\n\n1. Introduction  \nBreast cancer is the most frequently diagnosed malignancy in women. Globally, approximately 16.7% of cancer-related deaths in women are attributed to breast cancer. [1,2] Breast cancer commonly metastasizes to the liver, bones, lungs, brain, and lymph nodes. [3] Studies have reported that gastrointestinal metastases  \noccur in approximately 2% to 18% of breast cancer patients, typically several years after diagnosis. Among these sites, the stomach is the most commonly affected, followed by the colon and rectum.[4,5] Invasive lobular carcinoma (ILC), accounting for 10% to 20% of breast tumors, is particularly prone to metastasis due to the loss of intercellular adhesion molecules. [6] Borst et  \nPJ, YL, YTZ, LCZ, and GXS contributed to this article equally.  \nThe patient has provided informed consent for publication of the case.  \nThe authors have no funding and conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are publicly available.  \nThe study was approved by the Ethics Committee of the Affiliated Hospital of North China University of S","cbCaijr2qdIEaeyq","https://ap.wps.com/l/cbCaijr2qdIEaeyq","pdf",771221,"English","# Abstract\n# Introduction\n# Case report\n## Patient history and clinical presentation\n## Imaging and diagnostic evaluation\n# Lessons","[{\"question\":\"How were the gastrointestinal metastases diagnosed?\",\"answer\":\"Computed tomography showed gastric and rectal thickening, and colonoscopy with biopsy demonstrated metastatic tumors originating from breast cancer based on pathological evaluation.\"}]","Unmasking hidden metastasis - A case report of gastrointestinal metastasis detected a decade after breast cancer diagnosis | PDF",1790190524]