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Dysbiosis, the disruption of the balance between beneficial and harmful bacteria, is linked to metabolic disorders, autoimmune diseases, and cancers. This review summarizes key genera involved in immune regulation and metabolism, details pathogenic contributions to inflammation and cancer progression, and examines microbiota-based therapies including probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, while outlining future research directions in multi-omics, diet-lifestyle impacts, and microbiota engineering.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unlocking-the-secrets-of-the-human-gut-microbiota-comprehensive-review-on-its-role-in-different-diseases/375774/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unlocking-the-secrets-of-the-human-gut-microbiota-comprehensive-review-on-its-role-in-different-diseases/375774.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does the human gut microbiota play in health?","Question",{"text":113,"@type":114},"It maintains overall health by influencing digestion, immune function, and disease susceptibility, and it supports gut barrier integrity and immune responses.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How is dysbiosis connected to disease?",{"text":118,"@type":114},"Dysbiosis disrupts the balance of beneficial and harmful bacteria and is associated with metabolic disorders, autoimmune diseases, and cancers, including inflammation and tissue damage.",{"name":120,"@type":111,"acceptedAnswer":121},"What microbiota-based therapies are discussed in the review?",{"text":122,"@type":114},"The review examines probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, aiming to restore balance and improve health outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},375774,1790475580,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 February 7; 31(5): 99913  \nDOI: 10.3748/wjg.v31.i5.99913 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nREVIEW  \nUnlocking the secrets of the human gut microbiota: Comprehensive review on its role in different diseases  \nJibon Kumar Paul, Mahir Azmal, ANM Shah Newaz Been Haque, Meghla Meem, Omar Faruk Talukder, Ajit Ghosh  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B, Grade C  \nNovelty: Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade B, Grade B  \nScientific Significance: Grade A, Grade A, Grade B  \nP-Reviewer: Hardi H; Shu FX  \nReceived: August 2, 2024  \nRevised: October 25, 2024  \nAccepted: December 5, 2024  \nPublished online: February 7, 2025  \nProcessing time: 149 Days and 17.4 Hours  \nJibon Kumar Paul, Mahir Azmal, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh,  \nBiochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh  \nMeghla Meem, Faculty of Medicine, Dhaka University, Dhaka 1000, Bangladesh  \nCorresponding author: Ajit Ghosh, PhD, Reader (Associate Professor), Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Kumargoan, Sylhet 3114, [Bangladesh.](Bangladesh. ajitghoshbd@gmail.com)[ ajitghoshbd@gmail.com](Bangladesh. ajitghoshbd@gmail.com)  \nAbstract  \nThe human gut microbiota, a complex and diverse community of microorganisms, plays a crucial role in maintaining overall health by influencing various physiological processes, including digestion, immune function, and disease susceptibility. The balance between beneficial and harmful bacteria is essential for health, with dysbiosis-disruption of this balance-linked to numerous conditions such as metabolic disorders, autoimmune diseases, and cancers. This review highlights key genera such as Enterococcus, Ruminococcus, Bacteroides, Bifidobacterium, Escherichia coli, Akkermansia muciniphila, Firmicutes (including Clostridium and Lactobacillus), and Roseburia due to their well-established roles in immune regulation and metabolic processes, but other bacteria, including Clostridioides difficile, Salmonella, Helicobacter pylori, and Fusobacterium nucleatum, are also implicated in dysbiosis and various diseases. Pathogenic bacteria, including Escherichia coli and Bacteroides fragilis, contribute to inflammation and cancer progression by disrupting immune responses and damaging tissues. The potential for microbiota-based therapies, such as probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, to improve health outcomes is examined. Future research directions in the integration of multi-omics, the impact of diet and lifestyle on microbiota composition, and advancing microbiota engineering techniques are also discussed. Understanding the gut microbiota’s role in health and disease is essential for formulating personalized, efficacious treatments and preventive strategies, thereby enhancing health outcomes and progressing microbiome research.  \nKey Words: Gut microbiota; Cancer; Diabetics; Autoimmune disease; Dysbiosis  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 February 7, 2025  Volume 31  Issue 5   \nPaul JK et al. Role of the human gut microbiota  \nCore Tip: The human gut microbiota, a complex and diverse community of microorganisms, plays a critical role in maintaining health by influencing digestion, immune function, and disease susceptibility. Dysbiosis, an imbalance in this microbial community, is linked to conditions such as metabolic disorders, aut","cbCaikDOBxc1FkL7","https://ap.wps.com/l/cbCaikDOBxc1FkL7","pdf",3238446,"English","# Abstract\n## Core Tip\n## Introduction","[{\"question\":\"What role does the human gut microbiota play in health?\",\"answer\":\"It maintains overall health by influencing digestion, immune function, and disease susceptibility, and it supports gut barrier integrity and immune responses.\"},{\"question\":\"How is dysbiosis connected to disease?\",\"answer\":\"Dysbiosis disrupts the balance of beneficial and harmful bacteria and is associated with metabolic disorders, autoimmune diseases, and cancers, including inflammation and tissue damage.\"},{\"question\":\"What microbiota-based therapies are discussed in the review?\",\"answer\":\"The review examines probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, aiming to restore balance and improve health outcomes.\"}]","Unlocking the secrets of the human gut microbiota - Comprehensive review on its role in different diseases | PDF",1790216086]