[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370680-105":59,"doc-detail-370680-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","unlocking-the-potential-of-tumor-targeting-peptides-in-precision-oncology-review","Unlocking the potential of tumor-targeting peptides in precision oncology - Review","","Targeted cancer therapy offers a credible alternative to conventional chemotherapy, which is constrained by poor selectivity, off-target toxicity, and the emergence of drug resistance. Tumor-targeting peptides are highlighted for advantages such as low immunogenicity, efficient tissue penetration, and straightforward chemical or structural modification. Their size, specificity, and conformational flexibility enable selective cancer-cell targeting while limiting injury to healthy tissue. The review synthesizes evidence on peptide structures, sources, mechanisms, standalone and fusion-drug applications, and supporting computational design and validation workflows.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unlocking-the-potential-of-tumor-targeting-peptides-in-precision-oncology-review/370680/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unlocking-the-potential-of-tumor-targeting-peptides-in-precision-oncology-review/370680.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are tumor-targeting peptides considered promising for precision oncology?","Question",{"text":112,"@type":113},"They offer minimal immunogenicity, high tissue penetration, and easy modification. Their small size and specificity help target cancer cells while reducing damage to healthy tissues.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What therapeutic applications of tumor-targeting peptides are covered in the review?",{"text":117,"@type":113},"The review discusses peptides as standalone therapeutic agents and also in fusion-drug formats. It emphasizes their roles in drug delivery and tumor imaging while aiming to reduce adverse effects.",{"name":119,"@type":110,"acceptedAnswer":120},"How do computational tools contribute to peptide-based tumor-targeting drug design?",{"text":121,"@type":113},"The review explores computational tools used to design and validate peptide-based tumor-targeting therapeutics. These approaches support discovery and help accelerate identification of candidate anti-tumor peptides.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},370680,1790673648,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","ONCOLOGY RESEARCH 2025 33(7): 1547-1570 REVIEW  \nUnlocking the potential of tumor-targeting peptides in precision oncology  \nHAFIZ MUHAMMAD REHMAN 1,2,*; SIDRA AHMAD2; AZEEM SARWAR1; HAMID BASHIR2,*  \n1 University Institute of Medical Lab Technology, Faculty of Allied Health Sciences, The University of Lahore, Lahore, 54590, Pakistan  \n2 Centre for Applied Molecular Biology, 87-West Canal, Bank Road, University of the Punjab, Lahore, 53700, Pakistan Key words: Targeting peptides, Peptide therapeutics, Anti-cancer peptide sources, Cancer cell mechanism, Cancer informatics  \nAbstract: Targeted cancer therapy has emerged as a promising alternative to conventional chemotherapy, which is often plagued by poor selectivity, off-target effects, and drug resistance. Among the various targeting agents in development, peptides stand out for their unique advantages, including minimal immunogenicity, high tissue penetration, and ease of modification. Their small size, specificity, and flexibility allow them to target cancer cells while minimizing damage to healthy tissue selectively. Peptide-based therapies have shown great potential in enhancing the efficacy of drug delivery, improving tumor imaging, and reducing adverse effects. With cancer responsible for millions of deaths worldwide, the development of peptide-based therapeutics offers new hope in addressing the limitations of current treatments. As detailed studies on different aspects of targeting peptides are crucial for optimizing drug development, this review provides a comprehensive overview of the literature on tumor-targeting peptides, including their structure, sources, modes of action, and their application in cancer therapy—both as standalone agents and in fusion drugs.  \nAdditionally, various computational tools for peptide-based tumor-targeting drug design and validation are explored.  \nThe promising results from these studies highlight peptides as ideal candidates for targeted cancer therapies, offering  \nvaluable insights for researchers and accelerating the discovery of novel anti-tumor peptide base drug candidates.  \nAbbreviations  \nBCR Breakpoint cluster region  \nABL Abelson murine leukemia  \nCML Chronic myeloid leukemia  \nACPs Anticancer peptides  \nEN1 Engrailed 1  \nEF-2 Elongation factor-2  \nMOMP Mitochondrial outer membrane  \npermeabilization  \nVEGF Vascular endothelial growth factor FADD Fas-associated death domain Tregs Regulatory T cells  \nNLS Nuclear localization signal  \nTKI Tyrosine kinase inhibitor  \nHER2 Human epidermal growth factor receptor 2  \n*Address correspondence to: Hafiz Muhammad Rehman, [muhammad.rehman@mlt.uol.edu.pk](muhammad.rehman@mlt.uol.edu.pk);  \nHamid Bashir, [hamid.camb@pu.edu.pk](hamid.camb@pu.edu.pk)  \nReceived: 12 December 2024; Accepted: 02 April 2025;  \nPublished: 26 June 2025  \nNF-κB  \nMMP-2 PNA Apaf-1 GRP-78 NRP-1 MAC CTLA-4 FOXP3 Trop-2 LAR  \nNMR  \nHTS  \nADCs  \nPPIs  \nFab  \nScFV  \nFACS  \nRCM  \nTME  \nPSMA  \nNuclear Factor kappa-light-chain-enhancer of activated B cells  \nMatrix Metalloproteinase-2  \nPeptide nucleic acid  \nApoptotic protease activating factor-1  \nGlucose-Regulated Protein 78  \nNeuropilin-1  \nMitochondrial apoptosis-induced channel Cytotoxic T Lymphocyte-Associated Antigen 4 Forkhead Box P3  \nTrophoblast cell surface antigen 2  \nLong acting release Nuclear magnetic resonance High throughput screening Antibody-drug conjugates Protein-protein interactions Antigen binding fragment  \nSingle chain variable fragment Fluorescence-activated cell sorting Ring-closing metathesis  \nTumor microenvironment Prostate-specific membrane antigen  \nDoi: [10.32604/or.2025.062197 www.techscience.com/journal/or](10.32604/or.2025.062197 www.techscience.com/journal/or)  \nCopyright © 2025 The Authors. Published by Tech Science Press.  \nThis work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \n154","cbCaisW8QNZSdOmn","https://ap.wps.com/l/cbCaisW8QNZSdOmn","pdf",5333879,24,"English","# Introduction\n# Targeted cancer therapy and the role of peptides\n## Advantages of tumor-targeting peptides\n## Mechanisms and selective targeting\n# Review scope: structures, sources, and modes of action\n## Standalone peptide therapeutics\n## Fusion drugs\n# Computational tools for peptide design and validation\n## Design and validation workflows\n# Abbreviations","[{\"question\":\"Why are tumor-targeting peptides considered promising for precision oncology?\",\"answer\":\"They offer minimal immunogenicity, high tissue penetration, and easy modification. Their small size and specificity help target cancer cells while reducing damage to healthy tissues.\"},{\"question\":\"What therapeutic applications of tumor-targeting peptides are covered in the review?\",\"answer\":\"The review discusses peptides as standalone therapeutic agents and also in fusion-drug formats. It emphasizes their roles in drug delivery and tumor imaging while aiming to reduce adverse effects.\"},{\"question\":\"How do computational tools contribute to peptide-based tumor-targeting drug design?\",\"answer\":\"The review explores computational tools used to design and validate peptide-based tumor-targeting therapeutics. These approaches support discovery and help accelerate identification of candidate anti-tumor peptides.\"}]","Unlocking the potential of tumor-targeting peptides in precision oncology - Review | PDF",1790189765]