[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-408055-105":59,"doc-detail-408055-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","unilateral-proptosis-mimicking-an-eye-tumour-a-case-report","Unilateral Proptosis Mimicking an Eye Tumour - A Case Report","","A 56-year-old woman presented with unilateral left-eye exophthalmos and recurrent bitemporal headache. She was hemodynamically stable with no focal neurological deficits, and initial labs (including D-dimer) were normal. Contrast-enhanced cranial CT excluded intracranial mass lesions and cerebral venous sinus thrombosis, while orbital MRI excluded primary orbital pathology. Thyroid testing showed markedly suppressed TSH and elevated free T4, with strongly positive TSH receptor antibodies, confirming Graves’ disease presenting atypically as unilateral ocular involvement.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unilateral-proptosis-mimicking-an-eye-tumour-a-case-report/408055/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unilateral-proptosis-mimicking-an-eye-tumour-a-case-report/408055.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What symptoms did the patient present with in this case report?","Question",{"text":113,"@type":114},"The patient presented with unilateral left-eye exophthalmos and recurrent bitemporal headache, with severe holocranial headache episodes and vomiting.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which diagnostic tests were used to rule out other causes?",{"text":118,"@type":114},"Initial laboratory tests were normal, D-dimer was negative, contrast-enhanced cranial CT excluded intracranial space-occupying lesions and cerebral venous sinus thrombosis, and orbital MRI excluded primary orbital pathology.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the diagnosis confirmed as Graves’ disease?",{"text":122,"@type":114},"Endocrine evaluation showed suppressed TSH and elevated free T4, and TSH receptor antibodies (TRAb) were markedly elevated, confirming Graves’ disease with atypical unilateral ocular involvement.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},408055,1790693620,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Review began 11/14/2025  \nReview ended 11/28/2025  \nPublished 12/01/2025  \n© Copyright 2025  \nMagalhães et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98229  \nOpen Access Case Report  \nUnilateral Proptosis Mimicking an Eye Tumour: A Case Report  \nAna Rita G. Magalhães 1 , Ana M. Carvalho 1, Pedro Almeida 1, Diana Mimoso 1, Sofia Perdigão 2, Beatriz T. Exposito 2  \n1. Internal Medicine, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Chaves, PRT 2. Internal Medicine, Centro Hospitalar de Trás-os-Montes e Alto Douro, Chaves, PRT  \nCorresponding author: Ana Rita G. Magalhães, [ana.r.g.magalhaes@gmail.com](ana.r.g.magalhaes@gmail.com)  \nAbstract  \nWe report the case of a 56-year-old woman who presented to the Emergency Department with unilateral exophthalmos ofthe left eye, accompanied by recurrent bitemporal headache. Her past medical history was significant for hypertension, ischemic heart disease, anxiety, depression, and obesity. On clinical examination, the patient was hemodynamically stable, alert, and fully oriented. A brief neurological assessment revealed no focal deficits.  \nInitial laboratory investigations, including complete blood count, serum electrolytes, and coagulation profile, were within normal limits. D-dimer levels were negative. A contrast-enhanced cranial computed tomography (CT) scan ruled out both intracranial space-occupying lesions and cerebral venous sinus thrombosis. Orbital magnetic resonance imaging (MRI) excluded any primary orbital pathology.  \nEndocrine evaluation of the hypothalamic-pituitary-thyroid axis revealed a suppressed thyroid-stimulating hormone (TSH) level of 0 .010 mUI/L (reference range: 0.27-4.20 mUI/L) and a free T4 level of 21 .59 pmol/L (reference range, adjusted for age and sex: 8.24-21.0 pmol/L) . Given the suspicion of Graves-Basedow disease with atypical unilateral ocular involvement, an autoimmune panel was performed. TSH receptor antibodies (TRAb) were markedly elevated at 11.0 U/L (reference range: 0-1.8 U/L), confirming the diagnosis of Graves’ disease.  \nGraves’ disease is an autoimmune thyroid disorder that typically presents with bilateral exophthalmos due to inflammatory changes and expansion of the extraocular muscles and orbital adipose tissue. However, unilateral exophthalmos, although uncommon, can occur as a manifestation of Graves’ orbitopathy.  \nCategories: Internal Medicine, Ophthalmology, Endocrinology/Diabetes/Metabolism  \nKeywords: exophthalmos, graves-basedow, orbitopathy, thyroid eye disease, tumor, unilateral  \nIntroduction  \nGraves ' disease is a tissue-specific autoimmune disease characterized by the production of autoantibodies that stimulate the thyrotropin (thyroid-stimulating hormone, or TSH) receptor on thyroid follicular cells.  \nThis pathological stimulation leads to the unregulated synthesis and production of thyroid hormones,  \nthyroxine (T4) and triiodothyronine (T3) [1] .  \nThe most common extrathyroidal manifestation of this disease involves the eye and is known as thyroid eye disease (TED) or Graves ' orbitopathy [2] . In the European population, the prevalence is approximately 10/10,000 individuals [3], with 30 .9% for asymmetric and 10 . 7% for unilateral disease, and approximately 75% of patients with thyrotoxicosis develop TED within one year of diagnosis [4] .  \nUsually, the disease presents bilaterally and symmetrically, with symptoms such as lid retraction, proptosis, and diplopia [3] . Unilateral and asymmetrical Graves ' disease poses a significant diagnostic challenge due to its resemblance to a range of other conditions, including orbital tumour/pseudotumour, orbital cellulitis, cavernous sinus thrombosis, and intra-orbital neoplasms [3-5].  \nWe present a clinical case demonstrating the diagnost","cbCainxRjcbD1LuB","https://ap.wps.com/l/cbCainxRjcbD1LuB","pdf",3544392,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What symptoms did the patient present with in this case report?\",\"answer\":\"The patient presented with unilateral left-eye exophthalmos and recurrent bitemporal headache, with severe holocranial headache episodes and vomiting.\"},{\"question\":\"Which diagnostic tests were used to rule out other causes?\",\"answer\":\"Initial laboratory tests were normal, D-dimer was negative, contrast-enhanced cranial CT excluded intracranial space-occupying lesions and cerebral venous sinus thrombosis, and orbital MRI excluded primary orbital pathology.\"},{\"question\":\"How was the diagnosis confirmed as Graves’ disease?\",\"answer\":\"Endocrine evaluation showed suppressed TSH and elevated free T4, and TSH receptor antibodies (TRAb) were markedly elevated, confirming Graves’ disease with atypical unilateral ocular involvement.\"}]","Unilateral Proptosis Mimicking an Eye Tumour - A Case Report | PDF",1790578008]