[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458304-105":59,"doc-detail-458304-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","unexpected-malignancy-squamous-cell-carcinoma-arising-in-an-ovarian-mature-cystic-teratoma-case-report","Unexpected Malignancy: Squamous Cell Carcinoma Arising in an Ovarian Mature Cystic Teratoma - Case Report","","Although mature cystic teratomas (MCTs) of the ovary are typically benign, their rare malignant transformation into squamous cell carcinoma (SCC) creates major diagnostic and treatment challenges. Preoperative imaging often suggests a benign lesion, and the malignant component is usually identified only after histopathological evaluation. Reporting these cases improves awareness of this uncommon entity and supports vigilant management of ovarian teratomas, especially in women beyond reproductive age. The paper presents a 65-year-old woman whose histology revealed SCC despite benign imaging.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/unexpected-malignancy-squamous-cell-carcinoma-arising-in-an-ovarian-mature-cystic-teratoma-case-report/458304/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/unexpected-malignancy-squamous-cell-carcinoma-arising-in-an-ovarian-mature-cystic-teratoma-case-report/458304.png","ImageObject",300,407,{"name":92,"@type":93},"Damian","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is malignant transformation in a mature cystic teratoma difficult to diagnose before surgery?","Question",{"text":113,"@type":114},"Preoperative imaging and clinical manifestations are often nonspecific, so malignancy is frequently detected incidentally during surgery or after postoperative histopathological evaluation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What patient profile and symptoms were described in the case?",{"text":118,"@type":114},"A 65-year-old multiparous postmenopausal woman presented with severe, persistent abdominal pain and a palpable right lower quadrant mass, along with anorexia but no fever or weight loss.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the malignant diagnosis confirmed?",{"text":122,"@type":114},"Histopathology of the resected ovarian specimen showed a carcinomatous proliferation with malignant cellular features and maturation patterns such as keratin pearls.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},458304,1791099638,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},137451208677,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review began 11/21/2025  \nReview ended 12/05/2025  \nPublished 12/08/2025  \n© Copyright 2025  \nBekhakh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98775  \nOpen Access Case Report  \nUnexpected Malignancy: Squamous Cell Carcinoma Arising in an Ovarian Mature Cystic Teratoma Diagnosed Postoperatively  \nChaimae Bekhakh 1, Anass Haloui 1 , Mahmoud Aberkane 1, Nassira Karich 1, Amal Bennani 1  \n1. Pathology Department, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR  \nCorresponding author: Chaimae Bekhakh, [bekhakh.ch@gmail.com](bekhakh.ch@gmail.com)  \nAbstract  \nAlthough mature cystic teratomas (MCTs) of the ovary are typically benign, their rare malignant transformation (MT) into squamous cell carcinoma (SCC) represents a diagnostic and therapeutic challenge. Preoperative imaging frequently misleads clinicians by suggesting a benign lesion, and the malignant component is usually identified only after histopathological evaluation. Reporting such cases is valuable to raise awareness of this unusual entity and to emphasize the need for vigilance in the management of ovarian teratomas, particularly in women beyond reproductive age. We report the case of a 65-year-old woman in whom imaging suggested a benign teratoma, but histology revealed SCC, underlining the diagnostic challenge and the importance of awareness of this rare but clinically significant transformation.  \nCategories: Obstetrics/Gynecology, Pathology, Oncology  \nKeywords: malignant transformation, mature cystic teratoma, ovarian germ cell tumor, ovary, squamous cell carcinoma  \nIntroduction  \nMature cystic teratoma (MCT), also known as a dermoid cyst, is the most common ovarian germ cell tumor, predominantly affecting women of reproductive age, with bilateral involvement reported in approximately 10-17% of cases [1] . Histologically, MCTs are composed of well-differentiated tissues derived from all three germ layers-ectoderm, mesoderm, and endoderm-and are usually asymptomatic, although some patients may experience abdominal pain or pelvic fullness due to the tumor’s mass effect [2] . Despite their benign nature, malignant transformation (MT) occurs in about 1-2% of cases, most frequently in older or postmenopausal women, with squamous cell carcinoma (SCC) accounting for 75-90% of these malignancies [3] . The preoperative diagnosis of MT remains challenging, as both clinical manifestations and imaging findings are often nonspecific, and malignancy is frequently identified incidentally during surgery or postoperative histopathological evaluation [4] . Given the poor prognosis of SCC arising in MCT and the absence of standardized therapeutic guidelines, early recognition through the integration of clinical, radiological, and histopathological findings is essential to guide timely surgical and adjuvant management [5] .  \nThe objective of this article is to report a case of SCC arising in an MCT, incidentally diagnosed during intraoperative pathological examination.  \nCase Presentation  \nA 65-year-old multiparous postmenopausal woman presented with severe, persistent abdominal pain and a palpable mass in the right lower quadrant (RLQ) . She reported a six-month history of abdominal discomfort, which had worsened over the past three days. The pain was constant, non-positional, and non-radiating. She also experienced anorexia but denied fever or weight loss.  \nOn physical examination, the abdomen was notably distended, with a large, firm, immobile, and tender mass measuring approximately 150 × 100 mm.  \nComputed tomography scan of the abdomen and pelvis revealed a large cystic mass in the right ovary measuring 160 × 125 × 86 mm. The mass exhibited heterogeneous content, including both fluid a","cbCaifhxa6EPJ1Tx","https://ap.wps.com/l/cbCaifhxa6EPJ1Tx","pdf",4430949,"English","# Abstract\n# Introduction\n# Case Presentation\n## Imaging and Clinical Findings\n## Surgical Management\n## Histopathological Findings","[{\"question\":\"Why is malignant transformation in a mature cystic teratoma difficult to diagnose before surgery?\",\"answer\":\"Preoperative imaging and clinical manifestations are often nonspecific, so malignancy is frequently detected incidentally during surgery or after postoperative histopathological evaluation.\"},{\"question\":\"What patient profile and symptoms were described in the case?\",\"answer\":\"A 65-year-old multiparous postmenopausal woman presented with severe, persistent abdominal pain and a palpable right lower quadrant mass, along with anorexia but no fever or weight loss.\"},{\"question\":\"How was the malignant diagnosis confirmed?\",\"answer\":\"Histopathology of the resected ovarian specimen showed a carcinomatous proliferation with malignant cellular features and maturation patterns such as keratin pearls.\"}]","Unexpected Malignancy: Squamous Cell Carcinoma Arising in an Ovarian Mature Cystic Teratoma - Case Report | PDF",1790752530,15]